Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients

The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron statu...

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Autores: Ras Jiménez, Maria del Mar, Ramos Polo, Raúl, Francesch Manzano, Josep, Corbella Santano, Miriam, Morillas Climent, Herminio, Jose Bazán, Núria, Jiménez Marrero, Santiago, Garcimartín Cerezo, Paloma, Yun Viladomat, Sergi, Moliner Borja, Pedro, Torres Cardús, Blanca, Verdú Rotellar, Jose María, Diez Lopez, Carles, González Costello, José, García Romero, Elena, Frutos Seminario, Fernando de, Triguero Llonch, Laura, Enjuanes, Cristina, Tajes Orduña, Marta, Comín Colet, Josep
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/207858
Acceso en línea:https://hdl.handle.net/2445/207858
Access Level:acceso abierto
Palabra clave:Dèficit de ferro
Marcadors bioquímics
Iron deficiency diseases
Biochemical markers
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spelling Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure PatientsRas Jiménez, Maria del MarRamos Polo, RaúlFrancesch Manzano, JosepCorbella Santano, MiriamMorillas Climent, HerminioJose Bazán, NúriaJiménez Marrero, SantiagoGarcimartín Cerezo, PalomaYun Viladomat, SergiMoliner Borja, PedroTorres Cardús, BlancaVerdú Rotellar, Jose MaríaDiez Lopez, CarlesGonzález Costello, JoséGarcía Romero, ElenaFrutos Seminario, Fernando deTriguero Llonch, LauraEnjuanes, CristinaTajes Orduña, MartaComín Colet, JosepDèficit de ferroMarcadors bioquímicsIron deficiency diseasesBiochemical markersThe soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF. We selected patients with normal hemoglobin levels and normal systemic iron status. Tissue iron deficiency (ID) was defined as levels of sTfR > 75th percentile (1.63 mg per L). The primary endpoints were the distance walked in the 6 min walking test (6MWT) and the overall summary score (OSS) of the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The final study cohort consisted of 215 patients. Overall QoL was significantly worse (51 +/- 27 vs. 39 +/- 20, p-value = 0.006, respectively), and the 6 MWT distance was significantly worse in patients with tissue ID when compared to patients without tissue ID (206 +/- 179 m vs. 314 +/- 155, p-value < 0.0001, respectively). Higher sTfR levels, indicating increased iron demand, were associated with a shorter distance in the 6 MWT (standardized beta = -0.249, p < 0.001) and a higher MLHFQ OSS (standardized fi = 0.183, p-value = 0.008). In this study, we show that in patients with normal systemic iron parameters, higher levels of sTfR are strongly associated with an impaired submaximal exercise capacity and with worse QoL.MDPI AG2024202420232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/207858Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/jpm13081282Journal of Personalized Medicine, 2023, vol. 13, num. 8https://doi.org/10.3390/jpm13081282cc by (c) Ras Jiménez, Maria del Mar et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2078582026-05-29T05:05:01Z
dc.title.none.fl_str_mv Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
title Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
spellingShingle Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
Ras Jiménez, Maria del Mar
Dèficit de ferro
Marcadors bioquímics
Iron deficiency diseases
Biochemical markers
title_short Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
title_full Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
title_fullStr Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
title_full_unstemmed Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
title_sort Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
dc.creator.none.fl_str_mv Ras Jiménez, Maria del Mar
Ramos Polo, Raúl
Francesch Manzano, Josep
Corbella Santano, Miriam
Morillas Climent, Herminio
Jose Bazán, Núria
Jiménez Marrero, Santiago
Garcimartín Cerezo, Paloma
Yun Viladomat, Sergi
Moliner Borja, Pedro
Torres Cardús, Blanca
Verdú Rotellar, Jose María
Diez Lopez, Carles
González Costello, José
García Romero, Elena
Frutos Seminario, Fernando de
Triguero Llonch, Laura
Enjuanes, Cristina
Tajes Orduña, Marta
Comín Colet, Josep
author Ras Jiménez, Maria del Mar
author_facet Ras Jiménez, Maria del Mar
Ramos Polo, Raúl
Francesch Manzano, Josep
Corbella Santano, Miriam
Morillas Climent, Herminio
Jose Bazán, Núria
Jiménez Marrero, Santiago
Garcimartín Cerezo, Paloma
Yun Viladomat, Sergi
Moliner Borja, Pedro
Torres Cardús, Blanca
Verdú Rotellar, Jose María
Diez Lopez, Carles
González Costello, José
García Romero, Elena
Frutos Seminario, Fernando de
Triguero Llonch, Laura
Enjuanes, Cristina
Tajes Orduña, Marta
Comín Colet, Josep
author_role author
author2 Ramos Polo, Raúl
Francesch Manzano, Josep
Corbella Santano, Miriam
Morillas Climent, Herminio
Jose Bazán, Núria
Jiménez Marrero, Santiago
Garcimartín Cerezo, Paloma
Yun Viladomat, Sergi
Moliner Borja, Pedro
Torres Cardús, Blanca
Verdú Rotellar, Jose María
Diez Lopez, Carles
González Costello, José
García Romero, Elena
Frutos Seminario, Fernando de
Triguero Llonch, Laura
Enjuanes, Cristina
Tajes Orduña, Marta
Comín Colet, Josep
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dèficit de ferro
Marcadors bioquímics
Iron deficiency diseases
Biochemical markers
topic Dèficit de ferro
Marcadors bioquímics
Iron deficiency diseases
Biochemical markers
description The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF. We selected patients with normal hemoglobin levels and normal systemic iron status. Tissue iron deficiency (ID) was defined as levels of sTfR > 75th percentile (1.63 mg per L). The primary endpoints were the distance walked in the 6 min walking test (6MWT) and the overall summary score (OSS) of the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The final study cohort consisted of 215 patients. Overall QoL was significantly worse (51 +/- 27 vs. 39 +/- 20, p-value = 0.006, respectively), and the 6 MWT distance was significantly worse in patients with tissue ID when compared to patients without tissue ID (206 +/- 179 m vs. 314 +/- 155, p-value < 0.0001, respectively). Higher sTfR levels, indicating increased iron demand, were associated with a shorter distance in the 6 MWT (standardized beta = -0.249, p < 0.001) and a higher MLHFQ OSS (standardized fi = 0.183, p-value = 0.008). In this study, we show that in patients with normal systemic iron parameters, higher levels of sTfR are strongly associated with an impaired submaximal exercise capacity and with worse QoL.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/207858
url https://hdl.handle.net/2445/207858
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jpm13081282
Journal of Personalized Medicine, 2023, vol. 13, num. 8
https://doi.org/10.3390/jpm13081282
dc.rights.none.fl_str_mv cc by (c) Ras Jiménez, Maria del Mar et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Ras Jiménez, Maria del Mar et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412672351502336
score 15,812429

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