Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study

This study aims to evaluate the utility of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) test for various infectious indications, analyze its diagnostic value, and assess its correlation with suspected diagnoses. Additionally, secondary endpoints in...

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Autores: García-Zaragoza, Tania, Jover Diaz, Francisco, Peris García, Juan Jorge, Delgado Sánchez, Elisabet, Verdú-Rico, José, Lumbreras, Blanca
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/39353
Acceso en línea:https://hdl.handle.net/11000/39353
Access Level:acceso abierto
Palabra clave:18f-fdg pet/ct
bacteremia
diagnostic confirmation
fever of unknown origin
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spelling Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective StudyGarcía-Zaragoza, TaniaJover Diaz, FranciscoPeris García, Juan JorgeDelgado Sánchez, ElisabetVerdú-Rico, JoséLumbreras, Blanca18f-fdg pet/ctbacteremiadiagnostic confirmationfever of unknown originThis study aims to evaluate the utility of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) test for various infectious indications, analyze its diagnostic value, and assess its correlation with suspected diagnoses. Additionally, secondary endpoints include evaluating the test's usefulness in clinical management and identifying predictors of PET/CT positivity. Methods: A retrospective descriptive observational study was conducted on in-hospital patients who underwent 18F-FDG PET/CT for suspected infections. Results: A total of 89 patients were reviewed. The predominant symptoms were fever (68.5%) and respiratory symptoms (38.2%). The most common prior complementary tests were microbiological (89.9%) and imaging (94.4%). Indications for PET/CT included fever of unknown origin (27%), focal infections (20.2%), bacteremia (34.8%), and immunocompromised patients (18%). Diagnostic confirmation was achieved in 60.7% of cases. The test's usefulness (confirmation and unexpected findings) was 76.4%. Only 9.5% of patients without an initial diagnosis after PET/CT received a confirmatory diagnosis later. The subgroup analysis revealed that fever of unknown origin was associated with a lower probability of confirmation and usefulness, whereas focal infection was linked to a higher likelihood of diagnostic confirmation. However, these associations did not persist in multivariate analysis due to the limited sample size. Conclusion: Our study aims to optimize the diagnostic profitability of the 18F-FDG PET/CT test for specific infectious disease indications by analyzing previous literature. In our experience, the PET/CT test demonstrated a high percentage of diagnostic confirmation for patients with focal infections. In contrast, its diagnostic yield was significantly lower for prolonged fever of unknown origin.SpringerDepartamentos de la UMH::Medicina Clínica202620262025info:eu-repo/semantics/articleapplication/pdf9application/pdfhttps://hdl.handle.net/11000/39353reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés10.7759/cureus.77991info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/393532026-05-27T13:36:21Z
dc.title.none.fl_str_mv Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study
title Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study
spellingShingle Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study
García-Zaragoza, Tania
18f-fdg pet/ct
bacteremia
diagnostic confirmation
fever of unknown origin
title_short Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study
title_full Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study
title_fullStr Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study
title_full_unstemmed Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study
title_sort Diagnostic Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infectious Diseases: A Retrospective Study
dc.creator.none.fl_str_mv García-Zaragoza, Tania
Jover Diaz, Francisco
Peris García, Juan Jorge
Delgado Sánchez, Elisabet
Verdú-Rico, José
Lumbreras, Blanca
author García-Zaragoza, Tania
author_facet García-Zaragoza, Tania
Jover Diaz, Francisco
Peris García, Juan Jorge
Delgado Sánchez, Elisabet
Verdú-Rico, José
Lumbreras, Blanca
author_role author
author2 Jover Diaz, Francisco
Peris García, Juan Jorge
Delgado Sánchez, Elisabet
Verdú-Rico, José
Lumbreras, Blanca
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Medicina Clínica
dc.subject.none.fl_str_mv 18f-fdg pet/ct
bacteremia
diagnostic confirmation
fever of unknown origin
topic 18f-fdg pet/ct
bacteremia
diagnostic confirmation
fever of unknown origin
description This study aims to evaluate the utility of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) test for various infectious indications, analyze its diagnostic value, and assess its correlation with suspected diagnoses. Additionally, secondary endpoints include evaluating the test's usefulness in clinical management and identifying predictors of PET/CT positivity. Methods: A retrospective descriptive observational study was conducted on in-hospital patients who underwent 18F-FDG PET/CT for suspected infections. Results: A total of 89 patients were reviewed. The predominant symptoms were fever (68.5%) and respiratory symptoms (38.2%). The most common prior complementary tests were microbiological (89.9%) and imaging (94.4%). Indications for PET/CT included fever of unknown origin (27%), focal infections (20.2%), bacteremia (34.8%), and immunocompromised patients (18%). Diagnostic confirmation was achieved in 60.7% of cases. The test's usefulness (confirmation and unexpected findings) was 76.4%. Only 9.5% of patients without an initial diagnosis after PET/CT received a confirmatory diagnosis later. The subgroup analysis revealed that fever of unknown origin was associated with a lower probability of confirmation and usefulness, whereas focal infection was linked to a higher likelihood of diagnostic confirmation. However, these associations did not persist in multivariate analysis due to the limited sample size. Conclusion: Our study aims to optimize the diagnostic profitability of the 18F-FDG PET/CT test for specific infectious disease indications by analyzing previous literature. In our experience, the PET/CT test demonstrated a high percentage of diagnostic confirmation for patients with focal infections. In contrast, its diagnostic yield was significantly lower for prolonged fever of unknown origin.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/39353
url https://hdl.handle.net/11000/39353
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.7759/cureus.77991
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
9
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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