Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis

OBJECTIVE: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS: Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and a...

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Autores: Loomis, Dana, Guha, Neela, Kogevinas, Manolis, Fontana, Vincenzo, Gennaro, Valerio, Kolstad, Henrik A., McElvenny, Damien Martin, Sallmen, Markku, Saracci, Rodolfo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/122200
Acceso en línea:https://hdl.handle.net/2445/122200
Access Level:acceso abierto
Palabra clave:Càncer
Mortalitat
Cancer
Mortality
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spelling Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysisLoomis, DanaGuha, NeelaKogevinas, ManolisFontana, VincenzoGennaro, ValerioKolstad, Henrik A.McElvenny, Damien MartinSallmen, MarkkuSaracci, RodolfoCàncerMortalitatCancerMortalityOBJECTIVE: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS: Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene. RESULTS: Increased mortality from non-Hodgkin's lymphoma (NHL) was associated with the mean level of exposure to styrene in air (relative risk (RR) 2.31, 95% CI 1.29 to 4.12 per 100 ppm), but not with cumulative styrene exposure. Similar associations with mean exposure were observed for the oesophagus (RR 2.44, 95% CI 1.11 to 5.36 per 100 ppm) and pancreas (RR 1.89, 95% CI 1.17 to 3.09). Oesophageal cancer mortality was also associated with cumulative styrene exposure lagged 20 years (RR 1.16, 95% CI 1.03 to 1.31). No other cancer, including lung cancer, was associated with any indicator of styrene exposure. CONCLUSION: This reanalysis does not substantially change the conclusions of the original study with respect to NHL or lung cancer but new evidence concerning cancers of the oesophagus and pancreas merits further investigation.BMJ2018201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/122200Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1136/oemed-2018-105131Occupational and Environmental Medicine, 2018http://dx.doi.org/10.1136/oemed-2018-105131cc by (c) Loomis et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1222002026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
title Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
spellingShingle Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
Loomis, Dana
Càncer
Mortalitat
Cancer
Mortality
title_short Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
title_full Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
title_fullStr Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
title_full_unstemmed Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
title_sort Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
dc.creator.none.fl_str_mv Loomis, Dana
Guha, Neela
Kogevinas, Manolis
Fontana, Vincenzo
Gennaro, Valerio
Kolstad, Henrik A.
McElvenny, Damien Martin
Sallmen, Markku
Saracci, Rodolfo
author Loomis, Dana
author_facet Loomis, Dana
Guha, Neela
Kogevinas, Manolis
Fontana, Vincenzo
Gennaro, Valerio
Kolstad, Henrik A.
McElvenny, Damien Martin
Sallmen, Markku
Saracci, Rodolfo
author_role author
author2 Guha, Neela
Kogevinas, Manolis
Fontana, Vincenzo
Gennaro, Valerio
Kolstad, Henrik A.
McElvenny, Damien Martin
Sallmen, Markku
Saracci, Rodolfo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer
Mortalitat
Cancer
Mortality
topic Càncer
Mortalitat
Cancer
Mortality
description OBJECTIVE: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS: Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene. RESULTS: Increased mortality from non-Hodgkin's lymphoma (NHL) was associated with the mean level of exposure to styrene in air (relative risk (RR) 2.31, 95% CI 1.29 to 4.12 per 100 ppm), but not with cumulative styrene exposure. Similar associations with mean exposure were observed for the oesophagus (RR 2.44, 95% CI 1.11 to 5.36 per 100 ppm) and pancreas (RR 1.89, 95% CI 1.17 to 3.09). Oesophageal cancer mortality was also associated with cumulative styrene exposure lagged 20 years (RR 1.16, 95% CI 1.03 to 1.31). No other cancer, including lung cancer, was associated with any indicator of styrene exposure. CONCLUSION: This reanalysis does not substantially change the conclusions of the original study with respect to NHL or lung cancer but new evidence concerning cancers of the oesophagus and pancreas merits further investigation.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/122200
url https://hdl.handle.net/2445/122200
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1136/oemed-2018-105131
Occupational and Environmental Medicine, 2018
http://dx.doi.org/10.1136/oemed-2018-105131
dc.rights.none.fl_str_mv cc by (c) Loomis et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Loomis et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv BMJ
publisher.none.fl_str_mv BMJ
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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