Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea

Olea Fraile, Elena; Valverde Pérez, Esther; Docio Cuadrado, Inmaculada; Prieto Lloret, Jesús; Aaronson, Philip Irving; Rocher Martín, María Asunción

Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea

Producción Científica

Detalles Bibliográficos
Autores:	Olea Fraile, Elena, Valverde Pérez, Esther, Docio Cuadrado, Inmaculada, Prieto Lloret, Jesús, Aaronson, Philip Irving, Rocher Martín, María Asunción
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2024
País:	España
Institución:	Universidad de Valladolid
Repositorio:	UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:	oai:uvadoc.uva.es:10324/70072
Acceso en línea:	https://doi.org/10.3390/ijms25137484 https://uvadoc.uva.es/handle/10324/70072
Access Level:	acceso abierto
Palabra clave:	Pulmonary hypertension Hipertensión pulmonar Hipertensión arterial Hypoxia Anoxemia Respiratory organs -Diseases Organos respiratorios - Enfermedades Lungs - Blood-vessels - Diseases Pulmones - Vasos sanguíneos - Enfermedades Carotid body Cuerpo carotídeo Autonomic nervous system Nervioso Autónomo, Sistema Sleep apnea syndromes Síndrome de la apnea del sueño Endothelial function Endotelio vascular Guinea pig Animales de laboratorio Medicine 3205.08 Enfermedades Pulmonares 32 Ciencias Médicas

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spelling	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apneaOlea Fraile, ElenaValverde Pérez, EstherDocio Cuadrado, InmaculadaPrieto Lloret, JesúsAaronson, Philip IrvingRocher Martín, María AsunciónPulmonary hypertensionHipertensión pulmonarHipertensión arterialHypoxiaAnoxemiaRespiratory organs -DiseasesOrganos respiratorios - EnfermedadesLungs - Blood-vessels - DiseasesPulmones - Vasos sanguíneos - EnfermedadesCarotid bodyCuerpo carotídeoAutonomic nervous systemNervioso Autónomo, SistemaSleep apnea syndromesSíndrome de la apnea del sueñoEndothelial functionEndotelio vascularGuinea pigAnimales de laboratorioMedicine3205.08 Enfermedades Pulmonares32 Ciencias MédicasProducción CientíficaExperimental evidence suggests that chronic intermittent hypoxia (CIH), a major hallmark of obstructive sleep apnea (OSA), boosts carotid body (CB) responsiveness, thereby causing increased sympathetic activity, arterial and pulmonary hypertension, and cardiovascular disease. An enhanced circulatory chemoreflex, oxidative stress, and NO signaling appear to play important roles in these responses to CIH in rodents. Since the guinea pig has a hypofunctional CB (i.e., it is a natural CB knockout), in this study we used it as a model to investigate the CB dependence of the effects of CIH on pulmonary vascular responses, including those mediated by NO, by comparing them with those previously described in the rat. We have analyzed pulmonary artery pressure (PAP), the hypoxic pulmonary vasoconstriction (HPV) response, endothelial function both in vivo and in vitro, and vascular remodeling (intima–media thickness, collagen fiber content, and vessel lumen area). We demonstrate that 30 days of the exposure of guinea pigs to CIH (FiO2, 5% for 40 s, 30 cycles/h) induces pulmonary artery remodeling but does not alter endothelial function or the contractile response to phenylephrine (PE) in these arteries. In contrast, CIH exposure increased the systemic arterial pressure and enhanced the contractile response to PE while decreasing endothelium-dependent vasorelaxation to carbachol in the aorta without causing its remodeling. We conclude that since all of these effects are independent of CB sensitization, there must be other oxygen sensors, beyond the CB, with the capacity to alter the autonomic control of the heart and vascular function and structure in CIH.Ministerio de Economía, Comercio y Empresa (MINECO) y Fondo Europeo de Desarrollo Regional (FEDER) - (grant BFU2015-70616-R)Junta de Castilla y León, Consejería de Educación y Programa Estrategico IBGM - (grant CCVC8485)MDPI2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/ijms25137484https://uvadoc.uva.es/handle/10324/70072reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/1422-0067/25/13/7484info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/700722026-06-13T12:44:47Z
dc.title.none.fl_str_mv	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea
title	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea
spellingShingle	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea Olea Fraile, Elena Pulmonary hypertension Hipertensión pulmonar Hipertensión arterial Hypoxia Anoxemia Respiratory organs -Diseases Organos respiratorios - Enfermedades Lungs - Blood-vessels - Diseases Pulmones - Vasos sanguíneos - Enfermedades Carotid body Cuerpo carotídeo Autonomic nervous system Nervioso Autónomo, Sistema Sleep apnea syndromes Síndrome de la apnea del sueño Endothelial function Endotelio vascular Guinea pig Animales de laboratorio Medicine 3205.08 Enfermedades Pulmonares 32 Ciencias Médicas
title_short	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea
title_full	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea
title_fullStr	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea
title_full_unstemmed	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea
title_sort	Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea
dc.creator.none.fl_str_mv	Olea Fraile, Elena Valverde Pérez, Esther Docio Cuadrado, Inmaculada Prieto Lloret, Jesús Aaronson, Philip Irving Rocher Martín, María Asunción
author	Olea Fraile, Elena
author_facet	Olea Fraile, Elena Valverde Pérez, Esther Docio Cuadrado, Inmaculada Prieto Lloret, Jesús Aaronson, Philip Irving Rocher Martín, María Asunción
author_role	author
author2	Valverde Pérez, Esther Docio Cuadrado, Inmaculada Prieto Lloret, Jesús Aaronson, Philip Irving Rocher Martín, María Asunción
author2_role	author author author author author
dc.subject.none.fl_str_mv	Pulmonary hypertension Hipertensión pulmonar Hipertensión arterial Hypoxia Anoxemia Respiratory organs -Diseases Organos respiratorios - Enfermedades Lungs - Blood-vessels - Diseases Pulmones - Vasos sanguíneos - Enfermedades Carotid body Cuerpo carotídeo Autonomic nervous system Nervioso Autónomo, Sistema Sleep apnea syndromes Síndrome de la apnea del sueño Endothelial function Endotelio vascular Guinea pig Animales de laboratorio Medicine 3205.08 Enfermedades Pulmonares 32 Ciencias Médicas
topic	Pulmonary hypertension Hipertensión pulmonar Hipertensión arterial Hypoxia Anoxemia Respiratory organs -Diseases Organos respiratorios - Enfermedades Lungs - Blood-vessels - Diseases Pulmones - Vasos sanguíneos - Enfermedades Carotid body Cuerpo carotídeo Autonomic nervous system Nervioso Autónomo, Sistema Sleep apnea syndromes Síndrome de la apnea del sueño Endothelial function Endotelio vascular Guinea pig Animales de laboratorio Medicine 3205.08 Enfermedades Pulmonares 32 Ciencias Médicas
description	Producción Científica
publishDate	2024
dc.date.none.fl_str_mv	2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.3390/ijms25137484 https://uvadoc.uva.es/handle/10324/70072
url	https://doi.org/10.3390/ijms25137484 https://uvadoc.uva.es/handle/10324/70072
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	https://www.mdpi.com/1422-0067/25/13/7484
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid instname:Universidad de Valladolid
instname_str	Universidad de Valladolid
reponame_str	UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection	UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Pulmonary vascular responses to chronic intermittent hypoxia in a guinea pig model of obstructive sleep apnea

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