D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats

It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or drug-related behaviors,...

Descripción completa

Detalles Bibliográficos
Autores: Portero Tresserra, Marta|||0000-0003-4149-1339, Martí Nicolovius, Margarita|||0000-0002-8669-6285, Guillazo i Blanch, Gemma|||0000-0002-8297-7100, Boadas Vaello, Pere|||0000-0001-8497-1207, Vale Martínez, Anna|||0000-0001-7369-7134
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186510
Acceso en línea:https://ddd.uab.cat/record/186510
https://dx.doi.org/urn:doi:10.1016/j.nlm.2012.11.003
Access Level:acceso abierto
Palabra clave:D-cycloserine
NMDA receptor
Olfactory discrimination
Extinction
Reacquisition
Reconsolidation
id ES_89b1e68d76842e2ce4710faef514ad32
oai_identifier_str oai:ddd.uab.cat:186510
network_acronym_str ES
network_name_str España
repository_id_str
spelling D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in ratsPortero Tresserra, Marta|||0000-0003-4149-1339Martí Nicolovius, Margarita|||0000-0002-8669-6285Guillazo i Blanch, Gemma|||0000-0002-8297-7100Boadas Vaello, Pere|||0000-0001-8497-1207Vale Martínez, Anna|||0000-0001-7369-7134D-cycloserineNMDA receptorOlfactory discriminationExtinctionReacquisitionReconsolidationIt is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or drug-related behaviors, they have not been clearly determined in appetitive tasks using natural reinforcers. The current study examined the effects of pre-retrieval intra-basolateral amygdala (BLA) infusions of DCS on the extinction and reconsolidation of an appetitive odor discrimination task. Rats were trained to discriminate between three odors, one of which was associated with a palatable food reward, and, 20 min prior to extinction learning (experiment 1) or reactivation (experiment 2), they received bilateral intra-BLA infusions of DCS or vehicle. In experiment 1, DCS infusion reduced the rate of extinction learning, weakened extinction retention in a post-extinction test and enhanced reacquisition of the ODT task. In experiment 2, DCS improved subsequent memory expression in the reconsolidation test performed one day after the reactivation session. Such results indicate the involvement of BLA NMDA receptors in odor-food reward associative memory and suggest that DCS may potentiate the persistence or strength of the original memory trace. 22013-01-0120132013-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186510https://dx.doi.org/urn:doi:10.1016/j.nlm.2012.11.003reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PSI2008-04267Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 BES-2009-015395Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 JCI-208-2168open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1865102026-06-06T12:50:31Z
dc.title.none.fl_str_mv D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
title D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
spellingShingle D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
Portero Tresserra, Marta|||0000-0003-4149-1339
D-cycloserine
NMDA receptor
Olfactory discrimination
Extinction
Reacquisition
Reconsolidation
title_short D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
title_full D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
title_fullStr D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
title_full_unstemmed D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
title_sort D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
dc.creator.none.fl_str_mv Portero Tresserra, Marta|||0000-0003-4149-1339
Martí Nicolovius, Margarita|||0000-0002-8669-6285
Guillazo i Blanch, Gemma|||0000-0002-8297-7100
Boadas Vaello, Pere|||0000-0001-8497-1207
Vale Martínez, Anna|||0000-0001-7369-7134
author Portero Tresserra, Marta|||0000-0003-4149-1339
author_facet Portero Tresserra, Marta|||0000-0003-4149-1339
Martí Nicolovius, Margarita|||0000-0002-8669-6285
Guillazo i Blanch, Gemma|||0000-0002-8297-7100
Boadas Vaello, Pere|||0000-0001-8497-1207
Vale Martínez, Anna|||0000-0001-7369-7134
author_role author
author2 Martí Nicolovius, Margarita|||0000-0002-8669-6285
Guillazo i Blanch, Gemma|||0000-0002-8297-7100
Boadas Vaello, Pere|||0000-0001-8497-1207
Vale Martínez, Anna|||0000-0001-7369-7134
author2_role author
author
author
author
dc.subject.none.fl_str_mv D-cycloserine
NMDA receptor
Olfactory discrimination
Extinction
Reacquisition
Reconsolidation
topic D-cycloserine
NMDA receptor
Olfactory discrimination
Extinction
Reacquisition
Reconsolidation
description It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or drug-related behaviors, they have not been clearly determined in appetitive tasks using natural reinforcers. The current study examined the effects of pre-retrieval intra-basolateral amygdala (BLA) infusions of DCS on the extinction and reconsolidation of an appetitive odor discrimination task. Rats were trained to discriminate between three odors, one of which was associated with a palatable food reward, and, 20 min prior to extinction learning (experiment 1) or reactivation (experiment 2), they received bilateral intra-BLA infusions of DCS or vehicle. In experiment 1, DCS infusion reduced the rate of extinction learning, weakened extinction retention in a post-extinction test and enhanced reacquisition of the ODT task. In experiment 2, DCS improved subsequent memory expression in the reconsolidation test performed one day after the reactivation session. Such results indicate the involvement of BLA NMDA receptors in odor-food reward associative memory and suggest that DCS may potentiate the persistence or strength of the original memory trace.
publishDate 2013
dc.date.none.fl_str_mv 2
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/186510
https://dx.doi.org/urn:doi:10.1016/j.nlm.2012.11.003
url https://ddd.uab.cat/record/186510
https://dx.doi.org/urn:doi:10.1016/j.nlm.2012.11.003
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PSI2008-04267
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 BES-2009-015395
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 JCI-208-2168
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412646320603136
score 15,300724

Similares en LA Referencia