Data Documentation for: Chemo- and regioselective synthesis of 3,4-dihydro-pyrimidin-4-ones from 4,5-dihydro-1,2,4-oxadiazoles and chromium alkoxy alkynyl Fischer carbene complexes
A completely chemo- and regioselective synthesis of pyrimidin-4(3H)-ones by reaction between 4,5-dihydro-1,2,4-oxadiazoles and chromium alkoxy alkynyl Fischer carbene complexes is reported. Overall, it is a formal (3+3)-cycloaddition where 4,5-dihydro-1,2,4-oxadiazoles partake for the first time in...
| Autores: | , , , |
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| Tipo de recurso: | conjunto de datos |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Oviedo (UNIOVI) |
| Repositorio: | RUO. Repositorio Institucional de la Universidad de Oviedo |
| Idioma: | inglés |
| OAI Identifier: | oai:digibuo.uniovi.es:10651/80685 |
| Acceso en línea: | https://hdl.handle.net/10651/80685 https://dx.doi.org/10.17811/ruo_datasets.80685 |
| Access Level: | acceso abierto |
| Palabra clave: | Fischer carbene complexes, pyrimidones, cycloaddition, DFT calculations, oxadiazoles |
| Sumario: | A completely chemo- and regioselective synthesis of pyrimidin-4(3H)-ones by reaction between 4,5-dihydro-1,2,4-oxadiazoles and chromium alkoxy alkynyl Fischer carbene complexes is reported. Overall, it is a formal (3+3)-cycloaddition where 4,5-dihydro-1,2,4-oxadiazoles partake for the first time in the intermolecular formation of 6-membered heterocycles. Three points of diversity have been explored, and usually, synthetically useful isolated yields are reached, including one example at gram-scale. A reasonable mechanism, supported by DFT calculations, is proposed. |
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