Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study

BackgroundIn adult population with community acquired pneumonia high levels of pro-adrenomedullin (pro-ADM) have been shown to be predictors of worse prognosis. The role of this biomarker in pediatric patients had not been analyzed to date. The objective of this study is to know the levels of pro-AD...

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Autores: Sardà Sánchez, Marta, Calzada Hernández, Joan, Hernández Bou, Susanna, Claret Teruel, Gemma, Velasco Rodríguez, Jesús, Luaces Cubells, Carles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/30872
Acceso en línea:https://hdl.handle.net/2445/30872
Access Level:acceso abierto
Palabra clave:Infants malalts
Pneumònia adquirida a la comunitat
Marcadors bioquímics
Sick children
Community-acquired pneumonia
Biochemical markers
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spelling Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational studySardà Sánchez, MartaCalzada Hernández, JoanHernández Bou, SusannaClaret Teruel, GemmaVelasco Rodríguez, JesúsLuaces Cubells, CarlesInfants malaltsPneumònia adquirida a la comunitatMarcadors bioquímicsSick childrenCommunity-acquired pneumoniaBiochemical markersBackgroundIn adult population with community acquired pneumonia high levels of pro-adrenomedullin (pro-ADM) have been shown to be predictors of worse prognosis. The role of this biomarker in pediatric patients had not been analyzed to date. The objective of this study is to know the levels of pro-ADM in children with community acquired pneumonia (CAP) and analyze the relation between these levels and the patients¿ prognosis.FindingsProspective observational study including patients attended in the emergency service (January to October 2009) admitted to hospital with CAP and no complications at admission. The values for pro-ADM were analyzed in relation to: need for oxygen therapy, duration of oxygen therapy, fever and antibiotic therapy, complications, admission to the intensive care unit, and length of hospital stay. Fifty patients were included. Ten presented complications (7 pleural effusion). The median level of pro-ADM was 1.0065¿nmol/L (range 0.3715 to 7.2840¿nmol/L). The patients presenting complications had higher levels of pro-ADM (2.3190 vs. 1.1758¿nmol/L, p¿=¿0.013). Specifically, the presence of pleural effusion was associated with higher levels of pro-ADM (2.9440 vs. 1.1373¿nmol/L, p¿<¿0.001).ConclusionsIn our sample of patients admitted to hospital with CAP, pro-ADM levels are related to the development of complications during hospitalization.BioMed Central2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/30872Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1186/1756-0500-5-363BMC Research Notes 2012, 5:363http://dx.doi.org/10.1186/1756-0500-5-363cc-by (c) Sardà Sánchez et al., 2012http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/308722026-05-27T06:46:51Z
dc.title.none.fl_str_mv Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
title Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
spellingShingle Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
Sardà Sánchez, Marta
Infants malalts
Pneumònia adquirida a la comunitat
Marcadors bioquímics
Sick children
Community-acquired pneumonia
Biochemical markers
title_short Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
title_full Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
title_fullStr Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
title_full_unstemmed Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
title_sort Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
dc.creator.none.fl_str_mv Sardà Sánchez, Marta
Calzada Hernández, Joan
Hernández Bou, Susanna
Claret Teruel, Gemma
Velasco Rodríguez, Jesús
Luaces Cubells, Carles
author Sardà Sánchez, Marta
author_facet Sardà Sánchez, Marta
Calzada Hernández, Joan
Hernández Bou, Susanna
Claret Teruel, Gemma
Velasco Rodríguez, Jesús
Luaces Cubells, Carles
author_role author
author2 Calzada Hernández, Joan
Hernández Bou, Susanna
Claret Teruel, Gemma
Velasco Rodríguez, Jesús
Luaces Cubells, Carles
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Infants malalts
Pneumònia adquirida a la comunitat
Marcadors bioquímics
Sick children
Community-acquired pneumonia
Biochemical markers
topic Infants malalts
Pneumònia adquirida a la comunitat
Marcadors bioquímics
Sick children
Community-acquired pneumonia
Biochemical markers
description BackgroundIn adult population with community acquired pneumonia high levels of pro-adrenomedullin (pro-ADM) have been shown to be predictors of worse prognosis. The role of this biomarker in pediatric patients had not been analyzed to date. The objective of this study is to know the levels of pro-ADM in children with community acquired pneumonia (CAP) and analyze the relation between these levels and the patients¿ prognosis.FindingsProspective observational study including patients attended in the emergency service (January to October 2009) admitted to hospital with CAP and no complications at admission. The values for pro-ADM were analyzed in relation to: need for oxygen therapy, duration of oxygen therapy, fever and antibiotic therapy, complications, admission to the intensive care unit, and length of hospital stay. Fifty patients were included. Ten presented complications (7 pleural effusion). The median level of pro-ADM was 1.0065¿nmol/L (range 0.3715 to 7.2840¿nmol/L). The patients presenting complications had higher levels of pro-ADM (2.3190 vs. 1.1758¿nmol/L, p¿=¿0.013). Specifically, the presence of pleural effusion was associated with higher levels of pro-ADM (2.9440 vs. 1.1373¿nmol/L, p¿<¿0.001).ConclusionsIn our sample of patients admitted to hospital with CAP, pro-ADM levels are related to the development of complications during hospitalization.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/30872
url https://hdl.handle.net/2445/30872
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1186/1756-0500-5-363
BMC Research Notes 2012, 5:363
http://dx.doi.org/10.1186/1756-0500-5-363
dc.rights.none.fl_str_mv cc-by (c) Sardà Sánchez et al., 2012
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sardà Sánchez et al., 2012
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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