Ten Years of Experience Support Pharmacogenetic Testing to Guide Individualized Drug Therapy

[EN]Precision medicine utilizing the genetic information of genes involved in the metabolism and disposition of drugs can not only improve drug efficacy but also prevent or minimize adverse events. Polypharmacy is common among multimorbid patients and is associated with increased adverse events. One...

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Detalles Bibliográficos
Autores: Peña-Martín, María Celsa, García-Berrocal, Belén, Sánchez Martín, Almudena, Marcos-Vadillo, Elena, García-Salgado, María Jesús, Sánchez, Santiago, Lorenzo Romo, Carolina, González-Parra, David, Sans, Francisco, Franco Martín, Manuel Ángel, Gaedigk, Andrea, Mateos-Sexmero, María José, Sanz Lozano, Catalina Sofía, Isidoro García, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/158648
Acceso en línea:http://hdl.handle.net/10366/158648
Access Level:acceso abierto
Palabra clave:Pharmacogenetics
Polypharmacy
Precision medicine
Genetics
Allergy and Immunology
3207.01 Alergias
2409 Genética
alergia e inmunología
genética
Descripción
Sumario:[EN]Precision medicine utilizing the genetic information of genes involved in the metabolism and disposition of drugs can not only improve drug efficacy but also prevent or minimize adverse events. Polypharmacy is common among multimorbid patients and is associated with increased adverse events. One of the main objectives in health care is safe and efficacious drug therapy, which is directly correlated to the individual response to treatment. Precision medicine can increase drug safety in many scenarios, including polypharmacy. In this report, we share our experience utilizing precision medicine over the past ten years. Based on our experience using pharmacogenetic (PGx)-informed prescribing, we implemented a five-step precision medicine protocol (5SPM) that includes the assessment of the biological-clinical characteristics of the patient, current and past prescription history, and the patient's PGx test results. To illustrate our approach, we present cases highlighting the clinical relevance of precision medicine with a focus on patients with a complex history and polypharmacy.

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