The ever-evolving concept of the cancer stem cell in pancreatic cancer

This article belongs to the Special Issue Latest Development in Pancreatic Cancer.

Detalles Bibliográficos
Autores: Valle, Sandra, Martin-Hijano, Laura, Alcalá, Sonia, Alonso-Nocelo, Marta, Sainz, Bruno Jr.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/188483
Acceso en línea:http://hdl.handle.net/10261/188483
Access Level:acceso abierto
Palabra clave:EMT
Autophagy
Cancer stem cells
Chemoresistance
Hybrid cancer cell
Metabolism
Metastasis
Plasticity
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spelling The ever-evolving concept of the cancer stem cell in pancreatic cancerValle, SandraMartin-Hijano, LauraAlcalá, SoniaAlonso-Nocelo, MartaSainz, Bruno Jr.EMTAutophagyCancer stem cellsChemoresistanceHybrid cancer cellMetabolismMetastasisPlasticityThis article belongs to the Special Issue Latest Development in Pancreatic Cancer.Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is the 4th most frequent cause of cancer-related death worldwide, primarily due to the inherent chemoresistant nature and metastatic capacity of this tumor. The latter is believed to be mainly due to the existence of a subpopulation of highly plastic "stem"-like cells within the tumor, known as cancer stem cells (CSCs), which have been shown to have unique metabolic, autophagic, invasive, and chemoresistance properties that allow them to continuously self-renew and escape chemo-therapeutic elimination. As such, current treatments for the majority of PDAC patients are not effective and do not significantly impact overall patient survival (<7 months) as they do not affect the pancreatic CSC (PaCSC) population. In this context, it is important to highlight the need to better understand the characteristics of the PaCSC population in order to develop new therapies to target these cells. In this review, we will provide the latest updates and knowledge on the inherent characteristics of PaCSCs, particularly their unique biological properties including chemoresistance, epithelial to mesenchymal transition, plasticity, metabolism and autophagy.Peer reviewedMultidisciplinary Digital Publishing InstituteValle, Sandra [0000-0002-7555-9357]Martin-Hijano, Laura [0000-0003-0666-533X]Alonso-Nocelo, Marta [0000-0001-8838-363X]Sainz, Bruno Jr. [0000-0003-4829-7651]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/188483reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/cancers10020033Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1884832026-05-22T06:33:51Z
dc.title.none.fl_str_mv The ever-evolving concept of the cancer stem cell in pancreatic cancer
title The ever-evolving concept of the cancer stem cell in pancreatic cancer
spellingShingle The ever-evolving concept of the cancer stem cell in pancreatic cancer
Valle, Sandra
EMT
Autophagy
Cancer stem cells
Chemoresistance
Hybrid cancer cell
Metabolism
Metastasis
Plasticity
title_short The ever-evolving concept of the cancer stem cell in pancreatic cancer
title_full The ever-evolving concept of the cancer stem cell in pancreatic cancer
title_fullStr The ever-evolving concept of the cancer stem cell in pancreatic cancer
title_full_unstemmed The ever-evolving concept of the cancer stem cell in pancreatic cancer
title_sort The ever-evolving concept of the cancer stem cell in pancreatic cancer
dc.creator.none.fl_str_mv Valle, Sandra
Martin-Hijano, Laura
Alcalá, Sonia
Alonso-Nocelo, Marta
Sainz, Bruno Jr.
author Valle, Sandra
author_facet Valle, Sandra
Martin-Hijano, Laura
Alcalá, Sonia
Alonso-Nocelo, Marta
Sainz, Bruno Jr.
author_role author
author2 Martin-Hijano, Laura
Alcalá, Sonia
Alonso-Nocelo, Marta
Sainz, Bruno Jr.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Valle, Sandra [0000-0002-7555-9357]
Martin-Hijano, Laura [0000-0003-0666-533X]
Alonso-Nocelo, Marta [0000-0001-8838-363X]
Sainz, Bruno Jr. [0000-0003-4829-7651]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv EMT
Autophagy
Cancer stem cells
Chemoresistance
Hybrid cancer cell
Metabolism
Metastasis
Plasticity
topic EMT
Autophagy
Cancer stem cells
Chemoresistance
Hybrid cancer cell
Metabolism
Metastasis
Plasticity
description This article belongs to the Special Issue Latest Development in Pancreatic Cancer.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/188483
url http://hdl.handle.net/10261/188483
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/cancers10020033
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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