Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects

Background: Hydrogen peroxide (H2O2) is a toxic agent that induces oxidative stress and cell death. Silicon (Si) is a biological element involved in limiting aluminium (Al) absorption with possible preventive effects in Alzheimer's disease. However, Si has not yet been associated with other neu...

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Detalles Bibliográficos
Autores: Garcimartín Álvarez, Alba, Merino Martín, José Joaquín, González Prieto, María Del Pilar, Sánchez Reus, María Isabel, Sánchez Muniz, Francisco José, Bastida Codina, Sara, Benedí González, Juana María
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/116409
Acceso en línea:https://hdl.handle.net/20.500.14352/116409
Access Level:acceso abierto
Palabra clave:Neurotoxicity
Neuroblastoma SH-SY5Y
Neuroprotection
Ciencias
24 Ciencias de la Vida
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spelling Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effectsGarcimartín Álvarez, AlbaMerino Martín, José JoaquínGonzález Prieto, María Del PilarSánchez Reus, María IsabelSánchez Muniz, Francisco JoséBastida Codina, SaraBenedí González, Juana MaríaNeurotoxicityNeuroblastoma SH-SY5YNeuroprotectionCiencias24 Ciencias de la VidaBackground: Hydrogen peroxide (H2O2) is a toxic agent that induces oxidative stress and cell death. Silicon (Si) is a biological element involved in limiting aluminium (Al) absorption with possible preventive effects in Alzheimer's disease. However, Si has not yet been associated with other neuroprotective mechanisms. Methods: The present experiments evaluated in the SH-SY5Y human neuroblastoma cell line the possible role of different Si G5 (50-1000 ng/mL) concentrations in preventing cellular death induced by H2O2 (400 μM, 24 hours). Results: Our findings showed that H2O2 promoted cell death in the human SH-SY5Y cell cultures and this could be prevented by Si treatment. The loss in cell viability mediated by H2O2 was due to an apoptotic and necrotic process. Apoptotic death was incurred by regulating caspase-8 activity in the extrinsic pathway. The apoptotic and necrotic cell death induced by H2O2 was almost totally reversed by Si (50-500 ng/mL), indicating that it down-regulates both processes in H2O2 treated cells. Conclusions: According to our data, Si is able to increase SH-SY5Y cell survival throughout partially blocking cellular damage related to oxidative stress through a mechanism that would affect H2O2/ROS elimination.Springer NatureUniversidad Complutense de Madrid20142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/116409reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Not available AGL2011-29644-C02-02 UTILIZACION NUTRICIONAL Y EFECTOS CARDIO- Y CEREBRO-PROTECTORES DE EMULSIONES CARNICAS CON FASE LIPIDICA ACEITE DE CHIA Y CONTENIENDO SILICIO E HIDROXITIROSOL ENCAPSULADOSopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1164092026-06-02T12:44:21Z
dc.title.none.fl_str_mv Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
title Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
spellingShingle Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
Garcimartín Álvarez, Alba
Neurotoxicity
Neuroblastoma SH-SY5Y
Neuroprotection
Ciencias
24 Ciencias de la Vida
title_short Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
title_full Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
title_fullStr Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
title_full_unstemmed Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
title_sort Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
dc.creator.none.fl_str_mv Garcimartín Álvarez, Alba
Merino Martín, José Joaquín
González Prieto, María Del Pilar
Sánchez Reus, María Isabel
Sánchez Muniz, Francisco José
Bastida Codina, Sara
Benedí González, Juana María
author Garcimartín Álvarez, Alba
author_facet Garcimartín Álvarez, Alba
Merino Martín, José Joaquín
González Prieto, María Del Pilar
Sánchez Reus, María Isabel
Sánchez Muniz, Francisco José
Bastida Codina, Sara
Benedí González, Juana María
author_role author
author2 Merino Martín, José Joaquín
González Prieto, María Del Pilar
Sánchez Reus, María Isabel
Sánchez Muniz, Francisco José
Bastida Codina, Sara
Benedí González, Juana María
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Neurotoxicity
Neuroblastoma SH-SY5Y
Neuroprotection
Ciencias
24 Ciencias de la Vida
topic Neurotoxicity
Neuroblastoma SH-SY5Y
Neuroprotection
Ciencias
24 Ciencias de la Vida
description Background: Hydrogen peroxide (H2O2) is a toxic agent that induces oxidative stress and cell death. Silicon (Si) is a biological element involved in limiting aluminium (Al) absorption with possible preventive effects in Alzheimer's disease. However, Si has not yet been associated with other neuroprotective mechanisms. Methods: The present experiments evaluated in the SH-SY5Y human neuroblastoma cell line the possible role of different Si G5 (50-1000 ng/mL) concentrations in preventing cellular death induced by H2O2 (400 μM, 24 hours). Results: Our findings showed that H2O2 promoted cell death in the human SH-SY5Y cell cultures and this could be prevented by Si treatment. The loss in cell viability mediated by H2O2 was due to an apoptotic and necrotic process. Apoptotic death was incurred by regulating caspase-8 activity in the extrinsic pathway. The apoptotic and necrotic cell death induced by H2O2 was almost totally reversed by Si (50-500 ng/mL), indicating that it down-regulates both processes in H2O2 treated cells. Conclusions: According to our data, Si is able to increase SH-SY5Y cell survival throughout partially blocking cellular damage related to oxidative stress through a mechanism that would affect H2O2/ROS elimination.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/116409
url https://hdl.handle.net/20.500.14352/116409
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Not available AGL2011-29644-C02-02 UTILIZACION NUTRICIONAL Y EFECTOS CARDIO- Y CEREBRO-PROTECTORES DE EMULSIONES CARNICAS CON FASE LIPIDICA ACEITE DE CHIA Y CONTENIENDO SILICIO E HIDROXITIROSOL ENCAPSULADOS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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