Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system

Beer is by far the most widely consumed alcoholic beverage in the world. Moderate alcohol consumption in general has been inversely associated with incident cardiovascular disease in observational studies. However, it has been suggested that fermented beverages such as red wine and beer may confer g...

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Detalles Bibliográficos
Autor: Quifer Rada, Paola
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/404910
Acceso en línea:http://hdl.handle.net/10803/404910
Access Level:acceso abierto
Palabra clave:Trastorns de la nutrició
Trastornos de la nutrición
Nutrition disorders
Cardiologia
Cardiología
Cardiology
Metabòlits
Metabolitos
Metabolites
Polifenols
Polifenoles
Polyphenols
Cervesa
Cerveza
Beer
Ciències de la Salut
663/664
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oai_identifier_str oai:www.tdx.cat:10803/404910
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spelling Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular systemQuifer Rada, PaolaTrastorns de la nutricióTrastornos de la nutriciónNutrition disordersCardiologiaCardiologíaCardiologyMetabòlitsMetabolitosMetabolitesPolifenolsPolifenolesPolyphenolsCervesaCervezaBeerCiències de la Salut663/664Beer is by far the most widely consumed alcoholic beverage in the world. Moderate alcohol consumption in general has been inversely associated with incident cardiovascular disease in observational studies. However, it has been suggested that fermented beverages such as red wine and beer may confer greater protective effects than spirits owing to their higher polyphenolic content. Polyphenols are secondary plant metabolites that are not essential for short-term health status, however there is increasing evidence that long-term intake may reduce the incidence of chronic diseases such as cancer, type-II diabetes, cardiovascular diseases and neurodegenerative diseases. Beer phenolic profile is very diverse, most of the beer polyphenols come from malt, and the rest come from hops used during brewing. However, although hop polyphenols in beer are found in low concentrations, they are very specific to beer since they are not detected in other foods. Most techniques used in assessing the diet followed by individuals are based on self-reporting questionnaires, which are liable to systematic bias by factors such as age, gender, social desirability and approval. In this thesis, we aim to evaluate whether regular and moderate beer and non-alcoholic beer consumption may reduce cardiovascular disease risk. To assess beer intake one of the main objectives of this thesis was to find a reliable biomarkers of beer consumption, and for this purpose we developed and validated a new method to determine hops polyphenols (prenylflavonoids). We evaluated the effects of ethanol and the phenolic compounds of beer on classical and novel cardiovascular risk factors with an interventional nutritional trial with participants at high cardiovascular risk. Moreover, in a large, multicenter, randomized, parallel group we performed a prospective study aimed at assess the differential associations of wine, beer and spirit consumption with all-cause mortality and incidence of cardiovascular events.Universitat de BarcelonaLamuela Raventós, Rosa Ma.Jáuregui Pallarés, OlgaLamuela Raventós, Rosa Ma.Universitat de Barcelona. Facultat de Farmàcia i Ciències de l'Alimentació201720172017info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion243 p.application/pdfapplication/pdfhttp://hdl.handle.net/10803/404910TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésADVERTIMENT. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/4049102026-06-14T12:46:07Z
dc.title.none.fl_str_mv Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
title Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
spellingShingle Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
Quifer Rada, Paola
Trastorns de la nutrició
Trastornos de la nutrición
Nutrition disorders
Cardiologia
Cardiología
Cardiology
Metabòlits
Metabolitos
Metabolites
Polifenols
Polifenoles
Polyphenols
Cervesa
Cerveza
Beer
Ciències de la Salut
663/664
title_short Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
title_full Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
title_fullStr Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
title_full_unstemmed Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
title_sort Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
dc.creator.none.fl_str_mv Quifer Rada, Paola
author Quifer Rada, Paola
author_facet Quifer Rada, Paola
author_role author
dc.contributor.none.fl_str_mv Lamuela Raventós, Rosa Ma.
Jáuregui Pallarés, Olga
Lamuela Raventós, Rosa Ma.
Universitat de Barcelona. Facultat de Farmàcia i Ciències de l'Alimentació
dc.subject.none.fl_str_mv Trastorns de la nutrició
Trastornos de la nutrición
Nutrition disorders
Cardiologia
Cardiología
Cardiology
Metabòlits
Metabolitos
Metabolites
Polifenols
Polifenoles
Polyphenols
Cervesa
Cerveza
Beer
Ciències de la Salut
663/664
topic Trastorns de la nutrició
Trastornos de la nutrición
Nutrition disorders
Cardiologia
Cardiología
Cardiology
Metabòlits
Metabolitos
Metabolites
Polifenols
Polifenoles
Polyphenols
Cervesa
Cerveza
Beer
Ciències de la Salut
663/664
description Beer is by far the most widely consumed alcoholic beverage in the world. Moderate alcohol consumption in general has been inversely associated with incident cardiovascular disease in observational studies. However, it has been suggested that fermented beverages such as red wine and beer may confer greater protective effects than spirits owing to their higher polyphenolic content. Polyphenols are secondary plant metabolites that are not essential for short-term health status, however there is increasing evidence that long-term intake may reduce the incidence of chronic diseases such as cancer, type-II diabetes, cardiovascular diseases and neurodegenerative diseases. Beer phenolic profile is very diverse, most of the beer polyphenols come from malt, and the rest come from hops used during brewing. However, although hop polyphenols in beer are found in low concentrations, they are very specific to beer since they are not detected in other foods. Most techniques used in assessing the diet followed by individuals are based on self-reporting questionnaires, which are liable to systematic bias by factors such as age, gender, social desirability and approval. In this thesis, we aim to evaluate whether regular and moderate beer and non-alcoholic beer consumption may reduce cardiovascular disease risk. To assess beer intake one of the main objectives of this thesis was to find a reliable biomarkers of beer consumption, and for this purpose we developed and validated a new method to determine hops polyphenols (prenylflavonoids). We evaluated the effects of ethanol and the phenolic compounds of beer on classical and novel cardiovascular risk factors with an interventional nutritional trial with participants at high cardiovascular risk. Moreover, in a large, multicenter, randomized, parallel group we performed a prospective study aimed at assess the differential associations of wine, beer and spirit consumption with all-cause mortality and incidence of cardiovascular events.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/404910
url http://hdl.handle.net/10803/404910
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 243 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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