PPARs as Key Mediators in the Regulation of Metabolism and Inflammation

Nuclear receptors (NRs) form a large family of ligand-dependent transcription factors that control the expression of a multitude of genes involved in diverse, vital biological processes. Three of these receptors, the peroxisome proliferator-activated receptors (PPARs), were discovered in the 1990s a...

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Autores: Vázquez Carrera, Manuel, Wahli, Walter
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/191386
Acceso en línea:https://hdl.handle.net/2445/191386
Access Level:acceso abierto
Palabra clave:Receptors nuclears (Bioquímica)
Genètica bioquímica
Metabolisme cel·lular
Inflamació
Àcids grassos
Factors de transcripció
Nuclear receptors (Biochemistry)
Biochemical genetics
Cell metabolism
Inflammation
Fatty acids
Transcription factors
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spelling PPARs as Key Mediators in the Regulation of Metabolism and InflammationVázquez Carrera, ManuelWahli, WalterReceptors nuclears (Bioquímica)Genètica bioquímicaMetabolisme cel·lularInflamacióÀcids grassosFactors de transcripcióNuclear receptors (Biochemistry)Biochemical geneticsCell metabolismInflammationFatty acidsTranscription factorsNuclear receptors (NRs) form a large family of ligand-dependent transcription factors that control the expression of a multitude of genes involved in diverse, vital biological processes. Three of these receptors, the peroxisome proliferator-activated receptors (PPARs), were discovered in the 1990s and play key roles in the regulation of cellular differentiation, embryonic development, cellular and whole-body metabolism, inflammation, and tumorigenesis in higher organisms. PPARs are activated not only by fatty acids and their derivatives, some of which also signal through membrane receptors, but also by many plant- and marine-derived natural ligands. Furthermore, drugs that target PPARs, such as fibrates and thiazolidinediones, have been developed to treat metabolic diseases. The 'classic' molecular mode of action of PPARs in the control of physiological and metabolic processes is via their direct binding, as PPAR:retinoid X receptor (RXR) heterodimers, to peroxisome proliferator response elements (PPREs) in the regulatory regions of target genes. The activity of PPARs can also be modulated by posttranslational modifications and their transcriptional regulatory capacity may present a circadian pattern, depending on their expression and the availability of ligands.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/191386Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijms23095025International Journal of Molecular Sciences, 2022, vol. 23, num. 9, p. 5025https://doi.org/10.3390/ijms23095025cc-by (c) Vázquez Carrera, Manuel et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1913862026-05-27T06:46:51Z
dc.title.none.fl_str_mv PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
title PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
spellingShingle PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
Vázquez Carrera, Manuel
Receptors nuclears (Bioquímica)
Genètica bioquímica
Metabolisme cel·lular
Inflamació
Àcids grassos
Factors de transcripció
Nuclear receptors (Biochemistry)
Biochemical genetics
Cell metabolism
Inflammation
Fatty acids
Transcription factors
title_short PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
title_full PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
title_fullStr PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
title_full_unstemmed PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
title_sort PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
dc.creator.none.fl_str_mv Vázquez Carrera, Manuel
Wahli, Walter
author Vázquez Carrera, Manuel
author_facet Vázquez Carrera, Manuel
Wahli, Walter
author_role author
author2 Wahli, Walter
author2_role author
dc.subject.none.fl_str_mv Receptors nuclears (Bioquímica)
Genètica bioquímica
Metabolisme cel·lular
Inflamació
Àcids grassos
Factors de transcripció
Nuclear receptors (Biochemistry)
Biochemical genetics
Cell metabolism
Inflammation
Fatty acids
Transcription factors
topic Receptors nuclears (Bioquímica)
Genètica bioquímica
Metabolisme cel·lular
Inflamació
Àcids grassos
Factors de transcripció
Nuclear receptors (Biochemistry)
Biochemical genetics
Cell metabolism
Inflammation
Fatty acids
Transcription factors
description Nuclear receptors (NRs) form a large family of ligand-dependent transcription factors that control the expression of a multitude of genes involved in diverse, vital biological processes. Three of these receptors, the peroxisome proliferator-activated receptors (PPARs), were discovered in the 1990s and play key roles in the regulation of cellular differentiation, embryonic development, cellular and whole-body metabolism, inflammation, and tumorigenesis in higher organisms. PPARs are activated not only by fatty acids and their derivatives, some of which also signal through membrane receptors, but also by many plant- and marine-derived natural ligands. Furthermore, drugs that target PPARs, such as fibrates and thiazolidinediones, have been developed to treat metabolic diseases. The 'classic' molecular mode of action of PPARs in the control of physiological and metabolic processes is via their direct binding, as PPAR:retinoid X receptor (RXR) heterodimers, to peroxisome proliferator response elements (PPREs) in the regulatory regions of target genes. The activity of PPARs can also be modulated by posttranslational modifications and their transcriptional regulatory capacity may present a circadian pattern, depending on their expression and the availability of ligands.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/191386
url https://hdl.handle.net/2445/191386
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms23095025
International Journal of Molecular Sciences, 2022, vol. 23, num. 9, p. 5025
https://doi.org/10.3390/ijms23095025
dc.rights.none.fl_str_mv cc-by (c) Vázquez Carrera, Manuel et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Vázquez Carrera, Manuel et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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