Sex-specific thresholds of peak oxygen consumption for detecting cardiometabolic risk in children and adolescents with type 1 diabetes
Aims: To establish sex-specific peak oxygen consumption (VO2peak) thresholds that accurately discriminate cardiometabolic risk (CMR) in children and adolescents with type 1 diabetes and to validate these cut-off points using an independent cohort. Methods: This longitudinal study included 83 partici...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad Pública de Navarra |
| Repositorio: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/55331 |
| Acceso en línea: | https://hdl.handle.net/2454/55331 |
| Access Level: | acceso abierto |
| Palabra clave: | Aerobic fitness Cardiometabolic disease Insulin-dependent diabetes mellitus Youth |
| Sumario: | Aims: To establish sex-specific peak oxygen consumption (VO2peak) thresholds that accurately discriminate cardiometabolic risk (CMR) in children and adolescents with type 1 diabetes and to validate these cut-off points using an independent cohort. Methods: This longitudinal study included 83 participants (aged 8–18 years) with type 1 diabetes from the Diactive-1 cohort. VO2peak was assessed via maximal exercise testing with direct gas analysis, and CMR was calculated using a composite z-score of waist circumference, lipid profile, HbA1c, and blood pressure. VO2peak thresholds for CMR were identified by sex using logistic regression and receiver operating characteristic analysis, and externally validated in a Brazilian cohort (n = 36). A total of 62 individuals completed the 2-year follow-up assessment. Results: Optimal VO2peak thresholds were 40.8 ml/kg/min for boys and 33.7 ml/kg/min for girls, with areas under the curve of 0.71 and 0.78, respectively. Participants below these thresholds had significantly higher lipids and overall CMR. These associations persisted at the two-year follow-up and were confirmed in the Brazilian cohort, which also showed elevated HbA1c among high-risk individuals. Conclusions: Our study supports the clinical utility of these thresholds as a non-invasive marker of metabolic health and reinforce the importance of cardiorespiratory fitness promotion in this population. |
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