Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis

INTRODUCTION: There has been a growing awareness of the need for rigorously and transparent reported health research, to ensure the reproducibility of studies by future researchers. Health economic evaluations, the comparative analysis of alternative interventions in terms of their costs and consequ...

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Autores: Catalá-López, Ferrán, Caulley, Lisa, Ridao, Manuel, Hutton, Brian, Husereau, Don, Drummond, Michael F, Alonso-Arroyo, Adolfo, Pardo-Fernández, Manuel, Bernal-Delgado, Enrique, Meneu, Ricard, Tabarés-Seisdedos, Rafael, Repullo, Jose Ramon, Moher, David
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/9103
Acceso en línea:http://hdl.handle.net/20.500.12105/9103
Access Level:acceso abierto
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spelling Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysisCatalá-López, FerránCaulley, LisaRidao, ManuelHutton, BrianHusereau, DonDrummond, Michael FAlonso-Arroyo, AdolfoPardo-Fernández, ManuelBernal-Delgado, EnriqueMeneu, RicardTabarés-Seisdedos, RafaelRepullo, Jose RamonMoher, DavidINTRODUCTION: There has been a growing awareness of the need for rigorously and transparent reported health research, to ensure the reproducibility of studies by future researchers. Health economic evaluations, the comparative analysis of alternative interventions in terms of their costs and consequences, have been promoted as an important tool to inform decision-making. The objective of this study will be to investigate the extent to which articles of economic evaluations of healthcare interventions indexed in MEDLINE incorporate research practices that promote transparency, openness and reproducibility. METHODS AND ANALYSIS: This is the study protocol for a cross-sectional comparative analysis. We registered the study protocol within the Open Science Framework (osf.io/gzaxr). We will evaluate a random sample of 600 cost-effectiveness analysis publications, a specific form of health economic evaluations, indexed in MEDLINE during 2012 (n=200), 2019 (n=200) and 2022 (n=200). We will include published papers written in English reporting an incremental cost-effectiveness ratio in terms of costs per life years gained, quality-adjusted life years and/or disability-adjusted life years. Screening and selection of articles will be conducted by at least two researchers. Reproducible research practices, openness and transparency in each article will be extracted using a standardised data extraction form by multiple researchers, with a 33% random sample (n=200) extracted in duplicate. Information on general, methodological and reproducibility items will be reported, stratified by year, citation of the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement and journal. Risk ratios with 95% CIs will be calculated to represent changes in reporting between 2012-2019 and 2019-2022. ETHICS AND DISSEMINATION: Due to the nature of the proposed study, no ethical approval will be required. All data will be deposited in a cross-disciplinary public repository. It is anticipated the study findings could be relevant to a variety of audiences. Study findings will be disseminated at scientific conferences and published in peer-reviewed journals.BMJ Publishing GroupInstituto de Salud Carlos IIIRETICS-Servicios de Salud Orientados a Enfermedades Crónicas (REDISSEC-ISCIII) (España)20202020-02-1720202020-02-1320202020-02-13research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/9103reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/91032026-06-12T12:43:37Z
dc.title.none.fl_str_mv Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis
title Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis
spellingShingle Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis
Catalá-López, Ferrán
title_short Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis
title_full Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis
title_fullStr Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis
title_full_unstemmed Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis
title_sort Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis
dc.creator.none.fl_str_mv Catalá-López, Ferrán
Caulley, Lisa
Ridao, Manuel
Hutton, Brian
Husereau, Don
Drummond, Michael F
Alonso-Arroyo, Adolfo
Pardo-Fernández, Manuel
Bernal-Delgado, Enrique
Meneu, Ricard
Tabarés-Seisdedos, Rafael
Repullo, Jose Ramon
Moher, David
author Catalá-López, Ferrán
author_facet Catalá-López, Ferrán
Caulley, Lisa
Ridao, Manuel
Hutton, Brian
Husereau, Don
Drummond, Michael F
Alonso-Arroyo, Adolfo
Pardo-Fernández, Manuel
Bernal-Delgado, Enrique
Meneu, Ricard
Tabarés-Seisdedos, Rafael
Repullo, Jose Ramon
Moher, David
author_role author
author2 Caulley, Lisa
Ridao, Manuel
Hutton, Brian
Husereau, Don
Drummond, Michael F
Alonso-Arroyo, Adolfo
Pardo-Fernández, Manuel
Bernal-Delgado, Enrique
Meneu, Ricard
Tabarés-Seisdedos, Rafael
Repullo, Jose Ramon
Moher, David
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
RETICS-Servicios de Salud Orientados a Enfermedades Crónicas (REDISSEC-ISCIII) (España)
description INTRODUCTION: There has been a growing awareness of the need for rigorously and transparent reported health research, to ensure the reproducibility of studies by future researchers. Health economic evaluations, the comparative analysis of alternative interventions in terms of their costs and consequences, have been promoted as an important tool to inform decision-making. The objective of this study will be to investigate the extent to which articles of economic evaluations of healthcare interventions indexed in MEDLINE incorporate research practices that promote transparency, openness and reproducibility. METHODS AND ANALYSIS: This is the study protocol for a cross-sectional comparative analysis. We registered the study protocol within the Open Science Framework (osf.io/gzaxr). We will evaluate a random sample of 600 cost-effectiveness analysis publications, a specific form of health economic evaluations, indexed in MEDLINE during 2012 (n=200), 2019 (n=200) and 2022 (n=200). We will include published papers written in English reporting an incremental cost-effectiveness ratio in terms of costs per life years gained, quality-adjusted life years and/or disability-adjusted life years. Screening and selection of articles will be conducted by at least two researchers. Reproducible research practices, openness and transparency in each article will be extracted using a standardised data extraction form by multiple researchers, with a 33% random sample (n=200) extracted in duplicate. Information on general, methodological and reproducibility items will be reported, stratified by year, citation of the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement and journal. Risk ratios with 95% CIs will be calculated to represent changes in reporting between 2012-2019 and 2019-2022. ETHICS AND DISSEMINATION: Due to the nature of the proposed study, no ethical approval will be required. All data will be deposited in a cross-disciplinary public repository. It is anticipated the study findings could be relevant to a variety of audiences. Study findings will be disseminated at scientific conferences and published in peer-reviewed journals.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-02-17
2020
2020-02-13
2020
2020-02-13
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/9103
url http://hdl.handle.net/20.500.12105/9103
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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