T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations

Boaventura de Oliveira, Mateus; Garcia Vidal, Aran; Vidal Jordana, Angela; Quartana, Davide; Carvajal Junco, René Yeltsin; Auger Acosta, Cristina; Alberich Jordà, Manel; Tintore Subirana, Mar; Rovira Cañellas, Alex; Montalban Gairín, Xavier; Pareto Onghena, Deborah; Sastre Garriga, Jaume

T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations

Clinically isolated syndrome; Magnetic resonance imaging; Multiple sclerosis

Detalles Bibliográficos
Autores:	Boaventura de Oliveira, Mateus, Garcia Vidal, Aran, Vidal Jordana, Angela, Quartana, Davide, Carvajal Junco, René Yeltsin, Auger Acosta, Cristina, Alberich Jordà, Manel, Tintore Subirana, Mar, Rovira Cañellas, Alex, Montalban Gairín, Xavier, Pareto Onghena, Deborah, Sastre Garriga, Jaume
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:	Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:	oai:scientiasalut.gencat.cat:11351/7862
Acceso en línea:	https://hdl.handle.net/11351/7862
Access Level:	acceso abierto
Palabra clave:	Esclerosi múltiple - Imatgeria DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen

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network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
spellingShingle	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations Boaventura de Oliveira, Mateus Esclerosi múltiple - Imatgeria DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
title_short	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title_full	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title_fullStr	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title_full_unstemmed	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title_sort	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
dc.creator.none.fl_str_mv	Boaventura de Oliveira, Mateus Garcia Vidal, Aran Vidal Jordana, Angela Quartana, Davide Carvajal Junco, René Yeltsin Auger Acosta, Cristina Alberich Jordà, Manel Tintore Subirana, Mar Rovira Cañellas, Alex Montalban Gairín, Xavier Pareto Onghena, Deborah Sastre Garriga, Jaume
author	Boaventura de Oliveira, Mateus
author_facet	Boaventura de Oliveira, Mateus Garcia Vidal, Aran Vidal Jordana, Angela Quartana, Davide Carvajal Junco, René Yeltsin Auger Acosta, Cristina Alberich Jordà, Manel Tintore Subirana, Mar Rovira Cañellas, Alex Montalban Gairín, Xavier Pareto Onghena, Deborah Sastre Garriga, Jaume
author_role	author
author2	Garcia Vidal, Aran Vidal Jordana, Angela Quartana, Davide Carvajal Junco, René Yeltsin Auger Acosta, Cristina Alberich Jordà, Manel Tintore Subirana, Mar Rovira Cañellas, Alex Montalban Gairín, Xavier Pareto Onghena, Deborah Sastre Garriga, Jaume
author2_role	author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Institut Català de la Salut [Boaventura M, Sastre-Garriga J, Vidal-Jordana A, Quartana D, Carvajal R, Tintoré M, Montalban X] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. [Garcia-Vidal A, Auger C, Alberich M, Rovira À, Pareto D] Grup de Recerca en Neuroradiologia, Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv	Esclerosi múltiple - Imatgeria DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
topic	Esclerosi múltiple - Imatgeria DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
description	Clinically isolated syndrome; Magnetic resonance imaging; Multiple sclerosis
publishDate	2022
dc.date.none.fl_str_mv	2022 2022 2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/11351/7862
url	https://hdl.handle.net/11351/7862
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	NeuroImage: Clinical;34 https://doi.org/10.1016/j.nicl.2022.102967 info:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F00823
dc.rights.none.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str	Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str	Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection	Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associationsBoaventura de Oliveira, MateusGarcia Vidal, AranVidal Jordana, AngelaQuartana, DavideCarvajal Junco, René YeltsinAuger Acosta, CristinaAlberich Jordà, ManelTintore Subirana, MarRovira Cañellas, AlexMontalban Gairín, XavierPareto Onghena, DeborahSastre Garriga, JaumeEsclerosi múltiple - ImatgeriaDISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple SclerosisOther subheadings::Other subheadings::Other subheadings::/diagnostic imagingENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltipleOtros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagenClinically isolated syndrome; Magnetic resonance imaging; Multiple sclerosisSíndrome clínicamente aislado; Imágenes por resonancia magnética; Esclerosis múltipleSíndrome clínicament aïllat; Imatges per ressonància magnètica; Esclerosi múltipleBackground T1w/T2-w ratio has been proposed as a clinically feasible MRI biomarker to assess tissue integrity in multiple sclerosis. However, no data is available in the earliest stages of the disease and longitudinal studies analysing clinical associations are scarce. Objective To describe longitudinal changes in T1-w/T2-w in patients with clinically isolated syndrome (CIS) and multiple sclerosis, and to investigate their clinical associations. Methods T1-w/T2-w images were generated and the mean value obtained in the corresponding lesion, normal-appearing grey (NAGM) and white matter (NAWM) masks. By co-registering baseline to follow-up MRI, evolved lesions were assessed; and by placing the mask of new lesions to the baseline study, the pre-lesional tissue integrity was measured. Results We included 171 CIS patients and 22 established multiple sclerosis patients. In CIS, evolved lesions showed significant T1-w/T2-w increases compared to baseline (+7.6%, P < 0.001). T1-w/T2-w values in new lesions were lower than in pre-lesional tissue (-28.2%, P < 0.001), and pre-lesional tissue was already lower than baseline NAWM (-7.8%, P < 0.001). In CIS at baseline, higher NAGM T1-w/T2-w was associated with multiple sclerosis diagnosis, and longitudinal decreases in NAGM and NAWM T1-w/T2-w were associated with disease activity. In established multiple sclerosis, T1-w/T2-w was inversely correlated with clinical disability and disease duration. Conclusion A decrease in T1-w/T2-w ratio precedes lesion formation. In CIS, higher T1-w/T2-w was associated with multiple sclerosis diagnosis. In established multiple sclerosis, lower T1-w/T2-w values were associated with clinical disability. The possible differential impact of chronic inflammation, iron deposition and demyelination should be considered to interpret these findings.This project was developed as a part of Mateus Boaventura ECTRIMS Clinical Training Fellowship Programme 2018–2019. This study was partially supported by the Project PI18/00823, from the Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III.ElsevierInstitut Català de la Salut[Boaventura M, Sastre-Garriga J, Vidal-Jordana A, Quartana D, Carvajal R, Tintoré M, Montalban X] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. [Garcia-Vidal A, Auger C, Alberich M, Rovira À, Pareto D] Grup de Recerca en Neuroradiologia, Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7862Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésNeuroImage: Clinical;34https://doi.org/10.1016/j.nicl.2022.102967info:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F00823Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/78622026-06-12T09:38:37Z
score	15,812429

T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations

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