The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]

[EN] Nitroso-compounds are potentially mutagenic and carcinogenic compounds due to their ability to alkylate DNA bases. One of the most common sources of human exposure to nitroso-compounds is their formation in the acidic environment of the stomach by the reaction between electron-rich molecules pr...

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Detalles Bibliográficos
Autores: González Jiménez, Mario, García Santos, María Pilar, Bermejo Tesón, Blanca, Arenas Valgañón, Jorge, Calle Martín, Emilio, Casado, Julio
Tipo de recurso: conjunto de datos
Estado:Versión borrador
Fecha de publicación:2023
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/151517
Acceso en línea:http://hdl.handle.net/10366/151517
Access Level:acceso abierto
Palabra clave:Nitrosation
Neurotransmitter
Chemical kinetics
Mechanisms
Mutagenicity
2210.03 Cinética Química
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spelling The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]González Jiménez, MarioGarcía Santos, María PilarBermejo Tesón, BlancaArenas Valgañón, JorgeCalle Martín, EmilioCasado, JulioNitrosationNeurotransmitterChemical kineticsMechanismsMutagenicity2210.03 Cinética Química[EN] Nitroso-compounds are potentially mutagenic and carcinogenic compounds due to their ability to alkylate DNA bases. One of the most common sources of human exposure to nitroso-compounds is their formation in the acidic environment of the stomach by the reaction between electron-rich molecules present in the lumen and sodium nitrite ingested in the diet. To date, the formation of nitroso-compounds by the reaction of nitrite with food components has been investigated in depth, but little attention has been paid to substances secreted in the stomach, such as dopamine or serotonin, whose reaction products with nitrite have proven mutagenic properties. In this article we present a kinetic study with UV-visible spectroscopy of the nitrosation reactions of both molecules, as well as of L-tyrosine, the amino-acid precursor of dopamine. As a result, we have determined their reaction mechanisms, which show that in all of them the favoured reaction product is a stable nitroso-compound and that the molecule whose product is the most mutagenic, serotonin, undergoes two consecutive nitrosation reactions. These findings suggest that more research is needed to understand how this reaction alters the function of these neurotransmitters as well as the potential toxic effects they may have once nitrosated.a) Ministerio de Economía y Competitividad and the European Regional Development Fund. b) Universidad de Salamanca. M.G.J. had got a PhD. grant of the Ministerio de Economía y Competitividad J.A.V. had got a PhD. grant of the Junta de Castilla y León for a PhD. grant.Carpeta 1. Tirosine: 1. Extinction coefficient , 2. Extinction coefficient nitrosotirosine, 3. Reaction orders, 4. Influence Ionic ,Strength, 5. Influence Temperature, 6. Influence pH, 7. KIE. Carpeta 2. Dopamine: 1. Extinction coefficient, 2. Selfoxidation dopamine, 3. Extinction coefficient nitrosodopamine, 4. Catalysis by chloride ions, 5. Reaction orders, 6. Influence Ionic Strength, 7. Influence Temperature, 8. KIE. Carpeta 3. Serotonin: 1. Extinction coefficient, 2. Extinction coefficient nitrosated serotonin, 3. Influence Ionic Strength, 4. Reaction orders, 5. Influence pH, 6. Influence Temperature, 7. KIEUniversidad de Salamanca202320232023info:eu-repo/semantics/datasetinfo:eu-repo/semantics/drafthttp://hdl.handle.net/10366/151517reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Ingléshttp://hdl.handle.net/10366/154826Project CTQ2010- 18999Project 2019K125Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1515172026-06-07T06:28:51Z
dc.title.none.fl_str_mv The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]
title The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]
spellingShingle The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]
González Jiménez, Mario
Nitrosation
Neurotransmitter
Chemical kinetics
Mechanisms
Mutagenicity
2210.03 Cinética Química
title_short The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]
title_full The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]
title_fullStr The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]
title_full_unstemmed The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]
title_sort The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]
dc.creator.none.fl_str_mv González Jiménez, Mario
García Santos, María Pilar
Bermejo Tesón, Blanca
Arenas Valgañón, Jorge
Calle Martín, Emilio
Casado, Julio
author González Jiménez, Mario
author_facet González Jiménez, Mario
García Santos, María Pilar
Bermejo Tesón, Blanca
Arenas Valgañón, Jorge
Calle Martín, Emilio
Casado, Julio
author_role author
author2 García Santos, María Pilar
Bermejo Tesón, Blanca
Arenas Valgañón, Jorge
Calle Martín, Emilio
Casado, Julio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Nitrosation
Neurotransmitter
Chemical kinetics
Mechanisms
Mutagenicity
2210.03 Cinética Química
topic Nitrosation
Neurotransmitter
Chemical kinetics
Mechanisms
Mutagenicity
2210.03 Cinética Química
description [EN] Nitroso-compounds are potentially mutagenic and carcinogenic compounds due to their ability to alkylate DNA bases. One of the most common sources of human exposure to nitroso-compounds is their formation in the acidic environment of the stomach by the reaction between electron-rich molecules present in the lumen and sodium nitrite ingested in the diet. To date, the formation of nitroso-compounds by the reaction of nitrite with food components has been investigated in depth, but little attention has been paid to substances secreted in the stomach, such as dopamine or serotonin, whose reaction products with nitrite have proven mutagenic properties. In this article we present a kinetic study with UV-visible spectroscopy of the nitrosation reactions of both molecules, as well as of L-tyrosine, the amino-acid precursor of dopamine. As a result, we have determined their reaction mechanisms, which show that in all of them the favoured reaction product is a stable nitroso-compound and that the molecule whose product is the most mutagenic, serotonin, undergoes two consecutive nitrosation reactions. These findings suggest that more research is needed to understand how this reaction alters the function of these neurotransmitters as well as the potential toxic effects they may have once nitrosated.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
info:eu-repo/semantics/draft
format dataset
status_str draft
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/151517
url http://hdl.handle.net/10366/151517
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://hdl.handle.net/10366/154826
Project CTQ2010- 18999
Project 2019K125
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidad de Salamanca
publisher.none.fl_str_mv Universidad de Salamanca
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412588947767296
score 15,811543

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