Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation

This multicenter prospective study sponsored by the Grupo Español de Transplante Hematopoyético y Terapia Celular (GETH-TC) explores the use of frailty assessments in allo-HCT candidates. Frailty was measured using the HCT Frailty Scale at first consultation and HCT admission in 404 adults from 15 H...

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Detalles Bibliográficos
Autores: Salas, María Queralt|||0000-0003-4567-3682, Solano, María Teresa, Baile González, Mónica, Acera Gómez, Marina, Fox, Laura, Pérez Artigas, María del Mar, Santamaría, Ana, Quintela González, María del Carmen, Sánchez Salinas, Andrés|||0000-0001-9495-3555, Salmerón Camacho, Joaquina M., Illana Álvaro, Verónica, Abdallahi-Lefdil, Zahra, Cornago Navascues, Javier, Pardo, Laura|||0009-0009-9237-0634, Fernández-Luis, Sara|||0000-0001-9630-5893, Vega Suárez, Leddy Patricia, Villar, Sara, Beorlegui-Murillo, Patricia, Esquirol, Albert|||0000-0002-6062-5980, Izquierdo García, Isabel, Rodríguez González, Sonia, Mussetti, Alberto|||0000-0002-4088-036X, Lavilla, Esperanza|||0000-0003-1490-0678, Lopez-Marín, Javier, Filaferro, Silvia, Cedillo Cedillo, Angel|||0000-0002-0126-7044, Bento, Leyre|||0000-0001-9929-8617, Sureda, Anna|||0000-0002-1238-6970
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:319854
Acceso en línea:https://ddd.uab.cat/record/319854
https://dx.doi.org/urn:doi:10.3389/fimmu.2024.1512154
Access Level:acceso abierto
Palabra clave:Frailty syndrome
HCT Frailty Scale
allogeneic-HCT
Pre-habilitation
Survival
Descripción
Sumario:This multicenter prospective study sponsored by the Grupo Español de Transplante Hematopoyético y Terapia Celular (GETH-TC) explores the use of frailty assessments in allo-HCT candidates. Frailty was measured using the HCT Frailty Scale at first consultation and HCT admission in 404 adults from 15 HCT programs in Spain. Based on the results, patients were classified into fit, pre-frail and frail categories. Allo-HCT outcomes were analyzed according to the results obtained from the HCT Frailty Scale. Data was collected prospectively and all patients signed informed consent. At first consultation, 102 (26.2%) patients were classified as fit, 248 (61.4%) as pre-frail, and 50 (12.4%) as frail. During the study, 62 (15.2%) patients participated in a pre-habilitation program. Among non-pre-habilitated patients (n=342), the proportion of fit patients decreased from 26.6% to 16.7%, while frail patients increased from 12.7% to 19.9%. In contrast, pre-habilitated patients (n=62) showed improvements, with fit patients increasing from 24.2% to 46.8%, and frail patients decreasing from 9.7% to 3.2%. Multivariate analysis confirmed lower OS (HR 2.52, P=0.002) and higher NRM (HR 2.69, P=0.013) in frail patients at HCT admission compared to fit ones, with a trend towards lower OS in pre-frail patients (HR 1.54, P=0.097). This study highlights the feasibility of incorporating the HCT Frailty Scale into clinical practice, confirms its negative impact of frailty on transplant outcomes, and suggests that frailty is dynamic and potentially reversible through pre-transplant interventions.

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