Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure

Epithelial fusion is a key process of morphogenesis by which tissue connectivity is established between adjacent epithelial sheets. A striking and poorly understood feature of this process is "zippering," whereby a fusion point moves directionally along an organ rudiment. Here, we uncover...

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Detalles Bibliográficos
Autores: Molè, Matteo A., Galea, Gabriel L., Rolo, Ana, Weberling, Antonia, Nychyk, Oleksandr, Castro, Sandra, Savery, Dawn, Fässler, Reinhard, Ybot, Patricia, Greene, Nicholas D. E., Copp, Andrew J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/347934
Acceso en línea:http://hdl.handle.net/10261/347934
https://api.elsevier.com/content/abstract/scopus_id/85079337922
Access Level:acceso abierto
Palabra clave:Integrins
Cell adhesion
Epithelial zippering
Extracellular matrix
Fibronectin
Fusion
Gap
Closure
Morphogenesis
Neurulation
Spina bifida
Descripción
Sumario:Epithelial fusion is a key process of morphogenesis by which tissue connectivity is established between adjacent epithelial sheets. A striking and poorly understood feature of this process is "zippering," whereby a fusion point moves directionally along an organ rudiment. Here, we uncover the molecular mechanism underlying zippering during mouse spinal neural tube closure. Fusion is initiated via local activation of integrin β1 and focal anchorage of surface ectoderm cells to a shared point of fibronectin-rich basement membrane, where the neural folds first contact each other. Surface ectoderm cells undergo proximal junction shortening, establishing a transitory semi-rosette-like structure at the zippering point that promotes juxtaposition of cells across the midline enabling fusion propagation. Tissue-specific ablation of integrin β1 abolishes the semi-rosette formation, preventing zippering and causing spina bifida. We propose integrin-mediated anchorage as an evolutionarily conserved mechanism of general relevance for zippering closure of epithelial gaps whose disturbance can produce clinically important birth defects.