Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women

Nowadays, proinflammatory factors are considered to play an important role in the pathophysiology of threatened preterm labor or chorioamnionitis. The aim of this study was to establish the normal reference range for interleukin-6 (IL-6) levels in the amniotic fluid and to identify factors which may...

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Autores: del Barco, Ester|||0000-0002-1484-9027, Franco-Jarava, Clara|||0000-0002-9788-189X, Vargas Buján, Mireia|||0000-0002-4980-7652, Maiz, Nerea|||0000-0001-8261-6383, Arévalo, Silvia|||0000-0001-8169-1322, Sánchez, Maria Ángeles, Avilés García, M. T.|||0000-0003-3010-8752, Rodó, Carlota|||0000-0001-8801-5677, Mendoza, Manel|||0000-0002-3030-3833, Goya, M.|||0000-0003-4001-2017, Hernández-González, Manuel|||0000-0002-6932-5853, Carreras Moratonas, Elena|||0000-0003-3471-7248
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:280780
Acceso en línea:https://ddd.uab.cat/record/280780
https://dx.doi.org/urn:doi:10.1111/aogs.14524
Access Level:acceso abierto
Palabra clave:Amniocentesis
Amniotic fluid
Chorioamnionitis
Interleukin-6
Intra-amniotic infection
Intra-amniotic inflammation
Preterm labor
Spontaneous preterm delivery
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spelling Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant womendel Barco, Ester|||0000-0002-1484-9027Franco-Jarava, Clara|||0000-0002-9788-189XVargas Buján, Mireia|||0000-0002-4980-7652Maiz, Nerea|||0000-0001-8261-6383Arévalo, Silvia|||0000-0001-8169-1322Sánchez, Maria ÁngelesAvilés García, M. T.|||0000-0003-3010-8752Rodó, Carlota|||0000-0001-8801-5677Mendoza, Manel|||0000-0002-3030-3833Goya, M.|||0000-0003-4001-2017Hernández-González, Manuel|||0000-0002-6932-5853Carreras Moratonas, Elena|||0000-0003-3471-7248AmniocentesisAmniotic fluidChorioamnionitisInterleukin-6Intra-amniotic infectionIntra-amniotic inflammationPreterm laborSpontaneous preterm deliveryNowadays, proinflammatory factors are considered to play an important role in the pathophysiology of threatened preterm labor or chorioamnionitis. The aim of this study was to establish the normal reference range for interleukin-6 (IL-6) levels in the amniotic fluid and to identify factors which may alter this value. Prospective study in a tertiary-level center including asymptomatic pregnant women undergoing amniocentesis for genetic studies from October 2016 to September 2019. IL-6 measurements in amniotic fluid were performed using a fluorescence immunoassay with microfluidic technology (ELLA Proteinsimple, Bio Techne). Maternal history and pregnancy data were also recorded. This study included 140 pregnant women. Of those, women who underwent termination of pregnancy were excluded. Therefore, a total of 98 pregnancies were included in the final statistical analysis. The mean gestational age was 21.86 weeks (range: 15-38.7) at the time of amniocentesis, and 38.6 weeks (range: 30.9-41.4) at delivery. No cases of chorioamnionitis were reported. The log IL-6 values follow a normal distribution (W = 0.990, p = 0.692). The median, and the 5th, 10th, 90th, and 95th percentiles for IL-6 levels were 573, 105, 130, 1645, and 2260 pg/mL, respectively. The log IL-6 values were not affected by gestational age (p = 0.395), maternal age (p = 0.376), body mass index (p = 0.551), ethnicity (p = 0.467), smoking status (p = 0.933), parity (p = 0.557), method of conception (p = 0.322), or diabetes mellitus (p = 0.381). The log IL-6 values follow a normal distribution. IL-6 values are independent of gestational age, maternal age, body mass index, ethnicity, smoking status, parity and method of conception. Our study provides a normal reference range for IL-6 levels in the amniotic fluid that can be used in future studies. We also observed that normal IL-6 values were higher in the amniotic fluid than in serum. Interleukin-6 is a cytokine that has been linked to the pathophysiology of preterm labor and chorioamnionitis. This study provides a normal reference range for IL-6 levels in the amniotic fluid that can be used in future studies. This study also evaluates maternal and fetal factors that may potentially have an impact on IL-6 values.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/280780https://dx.doi.org/urn:doi:10.1111/aogs.14524reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2807802026-06-06T12:50:31Z
dc.title.none.fl_str_mv Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women
title Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women
spellingShingle Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women
del Barco, Ester|||0000-0002-1484-9027
Amniocentesis
Amniotic fluid
Chorioamnionitis
Interleukin-6
Intra-amniotic infection
Intra-amniotic inflammation
Preterm labor
Spontaneous preterm delivery
title_short Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women
title_full Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women
title_fullStr Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women
title_full_unstemmed Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women
title_sort Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women
dc.creator.none.fl_str_mv del Barco, Ester|||0000-0002-1484-9027
Franco-Jarava, Clara|||0000-0002-9788-189X
Vargas Buján, Mireia|||0000-0002-4980-7652
Maiz, Nerea|||0000-0001-8261-6383
Arévalo, Silvia|||0000-0001-8169-1322
Sánchez, Maria Ángeles
Avilés García, M. T.|||0000-0003-3010-8752
Rodó, Carlota|||0000-0001-8801-5677
Mendoza, Manel|||0000-0002-3030-3833
Goya, M.|||0000-0003-4001-2017
Hernández-González, Manuel|||0000-0002-6932-5853
Carreras Moratonas, Elena|||0000-0003-3471-7248
author del Barco, Ester|||0000-0002-1484-9027
author_facet del Barco, Ester|||0000-0002-1484-9027
Franco-Jarava, Clara|||0000-0002-9788-189X
Vargas Buján, Mireia|||0000-0002-4980-7652
Maiz, Nerea|||0000-0001-8261-6383
Arévalo, Silvia|||0000-0001-8169-1322
Sánchez, Maria Ángeles
Avilés García, M. T.|||0000-0003-3010-8752
Rodó, Carlota|||0000-0001-8801-5677
Mendoza, Manel|||0000-0002-3030-3833
Goya, M.|||0000-0003-4001-2017
Hernández-González, Manuel|||0000-0002-6932-5853
Carreras Moratonas, Elena|||0000-0003-3471-7248
author_role author
author2 Franco-Jarava, Clara|||0000-0002-9788-189X
Vargas Buján, Mireia|||0000-0002-4980-7652
Maiz, Nerea|||0000-0001-8261-6383
Arévalo, Silvia|||0000-0001-8169-1322
Sánchez, Maria Ángeles
Avilés García, M. T.|||0000-0003-3010-8752
Rodó, Carlota|||0000-0001-8801-5677
Mendoza, Manel|||0000-0002-3030-3833
Goya, M.|||0000-0003-4001-2017
Hernández-González, Manuel|||0000-0002-6932-5853
Carreras Moratonas, Elena|||0000-0003-3471-7248
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Amniocentesis
Amniotic fluid
Chorioamnionitis
Interleukin-6
Intra-amniotic infection
Intra-amniotic inflammation
Preterm labor
Spontaneous preterm delivery
topic Amniocentesis
Amniotic fluid
Chorioamnionitis
Interleukin-6
Intra-amniotic infection
Intra-amniotic inflammation
Preterm labor
Spontaneous preterm delivery
description Nowadays, proinflammatory factors are considered to play an important role in the pathophysiology of threatened preterm labor or chorioamnionitis. The aim of this study was to establish the normal reference range for interleukin-6 (IL-6) levels in the amniotic fluid and to identify factors which may alter this value. Prospective study in a tertiary-level center including asymptomatic pregnant women undergoing amniocentesis for genetic studies from October 2016 to September 2019. IL-6 measurements in amniotic fluid were performed using a fluorescence immunoassay with microfluidic technology (ELLA Proteinsimple, Bio Techne). Maternal history and pregnancy data were also recorded. This study included 140 pregnant women. Of those, women who underwent termination of pregnancy were excluded. Therefore, a total of 98 pregnancies were included in the final statistical analysis. The mean gestational age was 21.86 weeks (range: 15-38.7) at the time of amniocentesis, and 38.6 weeks (range: 30.9-41.4) at delivery. No cases of chorioamnionitis were reported. The log IL-6 values follow a normal distribution (W = 0.990, p = 0.692). The median, and the 5th, 10th, 90th, and 95th percentiles for IL-6 levels were 573, 105, 130, 1645, and 2260 pg/mL, respectively. The log IL-6 values were not affected by gestational age (p = 0.395), maternal age (p = 0.376), body mass index (p = 0.551), ethnicity (p = 0.467), smoking status (p = 0.933), parity (p = 0.557), method of conception (p = 0.322), or diabetes mellitus (p = 0.381). The log IL-6 values follow a normal distribution. IL-6 values are independent of gestational age, maternal age, body mass index, ethnicity, smoking status, parity and method of conception. Our study provides a normal reference range for IL-6 levels in the amniotic fluid that can be used in future studies. We also observed that normal IL-6 values were higher in the amniotic fluid than in serum. Interleukin-6 is a cytokine that has been linked to the pathophysiology of preterm labor and chorioamnionitis. This study provides a normal reference range for IL-6 levels in the amniotic fluid that can be used in future studies. This study also evaluates maternal and fetal factors that may potentially have an impact on IL-6 values.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/280780
https://dx.doi.org/urn:doi:10.1111/aogs.14524
url https://ddd.uab.cat/record/280780
https://dx.doi.org/urn:doi:10.1111/aogs.14524
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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