The Prophage and Us - Shiga Toxin Phages revisited

The authors first met in 1998 at the University of Würzburg, Germany, at the Institute of Hygiene and Microbiology, in Helge Karch's lab, where Herbert Schmidt worked as a PostDoc and Maite Muniesa visited the lab for a postdoctoral research stay to work on phages encoding Shiga toxin 2e (Stx2e...

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Autores: Schmidt, Herbert, Muniesa Pérez, Ma. Teresa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/193481
Acceso en línea:https://hdl.handle.net/2445/193481
Access Level:acceso abierto
Palabra clave:Escheríchia coli
Enterobacteriàcies
Toxines
Escherichia coli
Enterobacteriaceae
Toxins
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spelling The Prophage and Us - Shiga Toxin Phages revisitedSchmidt, HerbertMuniesa Pérez, Ma. TeresaEscheríchia coliEnterobacteriàciesToxinesEscherichia coliEnterobacteriaceaeToxinsThe authors first met in 1998 at the University of Würzburg, Germany, at the Institute of Hygiene and Microbiology, in Helge Karch's lab, where Herbert Schmidt worked as a PostDoc and Maite Muniesa visited the lab for a postdoctoral research stay to work on phages encoding Shiga toxin 2e (Stx2e) [1]. Since that time, we have been more or less, as much as our university duties allow, connected by Stx-phage research. Initially described in the early 1980s, Shiga toxin-converting bacteriophages (Stx-phages) have been the subject of numerous publications [ 2,3 ]. The ability to produce Stx, the major pathogenicity factor of enterohemorrhagic E. coli (EHEC), seems to be essentially connected to the location of the Shiga toxin genes (stx) in the genome of lysogenic phages, found always in a similar location within the late transcribed region, and upstream of the lysis and capsid genes [4 - 11]. Stx-phages are double-stranded DNA tailed phages showing a lambdoid or a non-lambdoid genome structure. To the best of our knowledge, stx genes have never been found in other mobile genetic elements other than phages, such as plasmids or pathogenicity islands [12 - 16 ]. Although the genetics and function of Stx-phages have been described in many publications, some basic questions remain still open, for example, (1) why are Stx-phages so successful in terms of evolution and spread among E. coli strains? (2) why do Stx-phages occur mainly in enteropathogenic E. coli strains but not, or only accidentally, in others such as extraintestinal pathogenic E. coli (EXPEC), (3) which advantage do EHEC strains have from the lysogenic state carrying single or multiple Stx-phages?MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/193481Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/pathogens12020232Pathogens, 2023, vol. 12, num. 2https://doi.org/10.3390/pathogens12020232cc-by (c) Schmidt, Herbert et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1934812026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Prophage and Us - Shiga Toxin Phages revisited
title The Prophage and Us - Shiga Toxin Phages revisited
spellingShingle The Prophage and Us - Shiga Toxin Phages revisited
Schmidt, Herbert
Escheríchia coli
Enterobacteriàcies
Toxines
Escherichia coli
Enterobacteriaceae
Toxins
title_short The Prophage and Us - Shiga Toxin Phages revisited
title_full The Prophage and Us - Shiga Toxin Phages revisited
title_fullStr The Prophage and Us - Shiga Toxin Phages revisited
title_full_unstemmed The Prophage and Us - Shiga Toxin Phages revisited
title_sort The Prophage and Us - Shiga Toxin Phages revisited
dc.creator.none.fl_str_mv Schmidt, Herbert
Muniesa Pérez, Ma. Teresa
author Schmidt, Herbert
author_facet Schmidt, Herbert
Muniesa Pérez, Ma. Teresa
author_role author
author2 Muniesa Pérez, Ma. Teresa
author2_role author
dc.subject.none.fl_str_mv Escheríchia coli
Enterobacteriàcies
Toxines
Escherichia coli
Enterobacteriaceae
Toxins
topic Escheríchia coli
Enterobacteriàcies
Toxines
Escherichia coli
Enterobacteriaceae
Toxins
description The authors first met in 1998 at the University of Würzburg, Germany, at the Institute of Hygiene and Microbiology, in Helge Karch's lab, where Herbert Schmidt worked as a PostDoc and Maite Muniesa visited the lab for a postdoctoral research stay to work on phages encoding Shiga toxin 2e (Stx2e) [1]. Since that time, we have been more or less, as much as our university duties allow, connected by Stx-phage research. Initially described in the early 1980s, Shiga toxin-converting bacteriophages (Stx-phages) have been the subject of numerous publications [ 2,3 ]. The ability to produce Stx, the major pathogenicity factor of enterohemorrhagic E. coli (EHEC), seems to be essentially connected to the location of the Shiga toxin genes (stx) in the genome of lysogenic phages, found always in a similar location within the late transcribed region, and upstream of the lysis and capsid genes [4 - 11]. Stx-phages are double-stranded DNA tailed phages showing a lambdoid or a non-lambdoid genome structure. To the best of our knowledge, stx genes have never been found in other mobile genetic elements other than phages, such as plasmids or pathogenicity islands [12 - 16 ]. Although the genetics and function of Stx-phages have been described in many publications, some basic questions remain still open, for example, (1) why are Stx-phages so successful in terms of evolution and spread among E. coli strains? (2) why do Stx-phages occur mainly in enteropathogenic E. coli strains but not, or only accidentally, in others such as extraintestinal pathogenic E. coli (EXPEC), (3) which advantage do EHEC strains have from the lysogenic state carrying single or multiple Stx-phages?
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/193481
url https://hdl.handle.net/2445/193481
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/pathogens12020232
Pathogens, 2023, vol. 12, num. 2
https://doi.org/10.3390/pathogens12020232
dc.rights.none.fl_str_mv cc-by (c) Schmidt, Herbert et al., 2023
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Schmidt, Herbert et al., 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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