Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images

Our goal was to study cerebral blood flow (CBF) changes after surgery in a group of 15 patients with idiopathic normal pressure hydrocephalus (NPH). Methods: We used hexamethylpropyleneamine oxime SPECT and statistical parametric mapping (SPM), an image analysis method that does not require prior se...

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Autores: Mataró Serrat, Maria, Poca Pastor, María Antonia, Salgado-Pineda, Pilar, Castell Conesa, Joan, Sahuquillo, Juan, Díez Castro, María Jesús, Aguadé Bruix, Santiago, Vendrell i Gómez, Pere, Matarín, Mar, Junqué i Plaja, Carme, 1955-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223417
Acceso en línea:https://hdl.handle.net/2445/223417
Access Level:acceso abierto
Palabra clave:Pacients amb lesions cerebrals
Líquid cefalorraquidi
Cirurgia cerebral
Brain damage patients
Cerebrospinal fluid
Cerebral surgery
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spelling Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT ImagesMataró Serrat, MariaPoca Pastor, María AntoniaSalgado-Pineda, PilarCastell Conesa, JoanSahuquillo, JuanDíez Castro, María JesúsAguadé Bruix, SantiagoVendrell i Gómez, PereMatarín, MarJunqué i Plaja, Carme, 1955-Pacients amb lesions cerebralsLíquid cefalorraquidiCirurgia cerebralBrain damage patientsCerebrospinal fluidCerebral surgeryOur goal was to study cerebral blood flow (CBF) changes after surgery in a group of 15 patients with idiopathic normal pressure hydrocephalus (NPH). Methods: We used hexamethylpropyleneamine oxime SPECT and statistical parametric mapping (SPM), an image analysis method that does not require prior selection of regions of interest. Results: Our study showed areas of significant increase in perfusion in specific regions of both frontal lobes and the right parietal lobe. Regions of increased perfusion were found in the left prefrontal dorsolateral areas (Brodmann’s areas 9 and 45 or 47), right frontal premotor area (Brodmann’s area 44), right medial prefrontal region (Brodmann’s area 10 or 32), right frontal white matter area (superior longitudinalis fasciculus), and right basal ganglia (lenticular nucleus, putamen, and globus pallidus). In the right hemisphere, another region of increased perfusion was found in the inferior parietal lobule (Brodmann’s area 40). The 2 areas most related to clinical improvement were Brodmann’s area 32 and the frontal part of the left lobule of Reil insula. Conclusion: The results obtained with the SPM method of image analysis confirm and expand on previous CBF literature in NPH, with specific CBF regions located in frontal and parietal areas that improve after surgery in idiopathic NPH.The Society of Nuclear Medicine and Molecular Imaging2025202520032025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/223417Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://jnm.snmjournals.org/content/44/12/1884Journal of Nuclear Medicine, 2003, vol. 44, num.12, p. 1884-1889(c) The Society of Nuclear Medicine and Molecular Imaging, 2003info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2234172026-05-29T05:05:01Z
dc.title.none.fl_str_mv Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images
title Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images
spellingShingle Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images
Mataró Serrat, Maria
Pacients amb lesions cerebrals
Líquid cefalorraquidi
Cirurgia cerebral
Brain damage patients
Cerebrospinal fluid
Cerebral surgery
title_short Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images
title_full Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images
title_fullStr Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images
title_full_unstemmed Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images
title_sort Postsurgical Cerebral Perfusion Changes in Idiopathic Normal Pressure Hydrocephalus: A Statistical Parametric Mapping Study of SPECT Images
dc.creator.none.fl_str_mv Mataró Serrat, Maria
Poca Pastor, María Antonia
Salgado-Pineda, Pilar
Castell Conesa, Joan
Sahuquillo, Juan
Díez Castro, María Jesús
Aguadé Bruix, Santiago
Vendrell i Gómez, Pere
Matarín, Mar
Junqué i Plaja, Carme, 1955-
author Mataró Serrat, Maria
author_facet Mataró Serrat, Maria
Poca Pastor, María Antonia
Salgado-Pineda, Pilar
Castell Conesa, Joan
Sahuquillo, Juan
Díez Castro, María Jesús
Aguadé Bruix, Santiago
Vendrell i Gómez, Pere
Matarín, Mar
Junqué i Plaja, Carme, 1955-
author_role author
author2 Poca Pastor, María Antonia
Salgado-Pineda, Pilar
Castell Conesa, Joan
Sahuquillo, Juan
Díez Castro, María Jesús
Aguadé Bruix, Santiago
Vendrell i Gómez, Pere
Matarín, Mar
Junqué i Plaja, Carme, 1955-
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pacients amb lesions cerebrals
Líquid cefalorraquidi
Cirurgia cerebral
Brain damage patients
Cerebrospinal fluid
Cerebral surgery
topic Pacients amb lesions cerebrals
Líquid cefalorraquidi
Cirurgia cerebral
Brain damage patients
Cerebrospinal fluid
Cerebral surgery
description Our goal was to study cerebral blood flow (CBF) changes after surgery in a group of 15 patients with idiopathic normal pressure hydrocephalus (NPH). Methods: We used hexamethylpropyleneamine oxime SPECT and statistical parametric mapping (SPM), an image analysis method that does not require prior selection of regions of interest. Results: Our study showed areas of significant increase in perfusion in specific regions of both frontal lobes and the right parietal lobe. Regions of increased perfusion were found in the left prefrontal dorsolateral areas (Brodmann’s areas 9 and 45 or 47), right frontal premotor area (Brodmann’s area 44), right medial prefrontal region (Brodmann’s area 10 or 32), right frontal white matter area (superior longitudinalis fasciculus), and right basal ganglia (lenticular nucleus, putamen, and globus pallidus). In the right hemisphere, another region of increased perfusion was found in the inferior parietal lobule (Brodmann’s area 40). The 2 areas most related to clinical improvement were Brodmann’s area 32 and the frontal part of the left lobule of Reil insula. Conclusion: The results obtained with the SPM method of image analysis confirm and expand on previous CBF literature in NPH, with specific CBF regions located in frontal and parietal areas that improve after surgery in idiopathic NPH.
publishDate 2003
dc.date.none.fl_str_mv 2003
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223417
url https://hdl.handle.net/2445/223417
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://jnm.snmjournals.org/content/44/12/1884
Journal of Nuclear Medicine, 2003, vol. 44, num.12, p. 1884-1889
dc.rights.none.fl_str_mv (c) The Society of Nuclear Medicine and Molecular Imaging, 2003
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) The Society of Nuclear Medicine and Molecular Imaging, 2003
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv The Society of Nuclear Medicine and Molecular Imaging
publisher.none.fl_str_mv The Society of Nuclear Medicine and Molecular Imaging
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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