Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis

Philasterides dicentrarchi is a free-living ciliate that causes high mortality in marine cultured fish, particularly flatfish, and in fish kept in aquaria. At present, there is still no clear picture of what makes this ciliate a fish pathogen and what makes fish resistant to this ciliate. In the pre...

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Autores: Valle Cao, Alejandra, Leiro Vidal, José Manuel, Pereiro González, Patricia, Figueras Huerta, Antonio, Novoa García, Beatriz, Dirks, Ron P.H., Lamas Fernández, Jesús
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/44518
Acceso en línea:https://hdl.handle.net/10347/44518
Access Level:acceso abierto
Palabra clave:Philasterides dicentrarchi
Turbot
Immune response
Transcriptomics
Infection
Investigación
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spelling Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysisValle Cao, AlejandraLeiro Vidal, José ManuelPereiro González, PatriciaFigueras Huerta, AntonioNovoa García, BeatrizDirks, Ron P.H.Lamas Fernández, JesúsPhilasterides dicentrarchiTurbotImmune responseTranscriptomicsInfectionInvestigaciónPhilasterides dicentrarchi is a free-living ciliate that causes high mortality in marine cultured fish, particularly flatfish, and in fish kept in aquaria. At present, there is still no clear picture of what makes this ciliate a fish pathogen and what makes fish resistant to this ciliate. In the present study, we used transcriptomic techniques to evaluate the interactions between P. dicentrarchi and turbot leucocytes during the early stages of infection. The findings enabled us to identify some parasite genes/proteins that may be involved in virulence and host resistance, some of which may be good candidates for inclusion in fish vaccines. Infected fish responded to infection by generating a very potent inflammatory response, indicating that the fish use all of the protective mechanisms available to prevent entry of the parasite. The findings also provide some valuable insight into how the acute inflammatory response occurs in fishMDPIUniversidade de Santiago de Compostela. Departamento de Bioloxía FuncionalUniversidade de Santiago de Compostela. Departamento de Microbioloxía e ParasitoloxíaUniversidade de Santiago de Compostela. Instituto de Investigación do Medio Acuático para Unha Saúde Global (iARCUS)20202020-10-1520202020-10-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/44518reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 634429open accesshttp://purl.org/coar/access_right/c_abf2© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/445182026-06-15T12:47:27Z
dc.title.none.fl_str_mv Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis
title Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis
spellingShingle Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis
Valle Cao, Alejandra
Philasterides dicentrarchi
Turbot
Immune response
Transcriptomics
Infection
Investigación
title_short Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis
title_full Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis
title_fullStr Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis
title_full_unstemmed Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis
title_sort Interactions between the Parasite Philasterides dicentrarchi and the immune system of the Turbot Scophthalmus maximus. A transcriptomic analysis
dc.creator.none.fl_str_mv Valle Cao, Alejandra
Leiro Vidal, José Manuel
Pereiro González, Patricia
Figueras Huerta, Antonio
Novoa García, Beatriz
Dirks, Ron P.H.
Lamas Fernández, Jesús
author Valle Cao, Alejandra
author_facet Valle Cao, Alejandra
Leiro Vidal, José Manuel
Pereiro González, Patricia
Figueras Huerta, Antonio
Novoa García, Beatriz
Dirks, Ron P.H.
Lamas Fernández, Jesús
author_role author
author2 Leiro Vidal, José Manuel
Pereiro González, Patricia
Figueras Huerta, Antonio
Novoa García, Beatriz
Dirks, Ron P.H.
Lamas Fernández, Jesús
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Bioloxía Funcional
Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía
Universidade de Santiago de Compostela. Instituto de Investigación do Medio Acuático para Unha Saúde Global (iARCUS)
dc.subject.none.fl_str_mv Philasterides dicentrarchi
Turbot
Immune response
Transcriptomics
Infection
Investigación
topic Philasterides dicentrarchi
Turbot
Immune response
Transcriptomics
Infection
Investigación
description Philasterides dicentrarchi is a free-living ciliate that causes high mortality in marine cultured fish, particularly flatfish, and in fish kept in aquaria. At present, there is still no clear picture of what makes this ciliate a fish pathogen and what makes fish resistant to this ciliate. In the present study, we used transcriptomic techniques to evaluate the interactions between P. dicentrarchi and turbot leucocytes during the early stages of infection. The findings enabled us to identify some parasite genes/proteins that may be involved in virulence and host resistance, some of which may be good candidates for inclusion in fish vaccines. Infected fish responded to infection by generating a very potent inflammatory response, indicating that the fish use all of the protective mechanisms available to prevent entry of the parasite. The findings also provide some valuable insight into how the acute inflammatory response occurs in fish
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-10-15
2020
2020-10-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/44518
url https://hdl.handle.net/10347/44518
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 634429
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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