Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex

[EN]The mismatch negativity (MMN) is a key biomarker of automatic deviance detection thought to emerge from 2 cortical sources. First, the auditory cortex (AC) encodes spectral regularities and reports frequency-specific deviances. Then, more abstract representations in the prefrontal cortex (PFC) a...

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Autores: Casado Román, Lorena, Carbajal, Guillermo V., Pérez González, David, Malmierca, Manuel S.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/144481
Acceso en línea:http://hdl.handle.net/10366/144481
Access Level:acceso abierto
Palabra clave:Prefrontal cortex
MMN
SSA
Auditory
Prediction error
2490 Neurociencias
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spelling Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortexCasado Román, LorenaCarbajal, Guillermo V.Pérez González, DavidMalmierca, Manuel S.Prefrontal cortexMMNSSAAuditoryPrediction error2490 Neurociencias[EN]The mismatch negativity (MMN) is a key biomarker of automatic deviance detection thought to emerge from 2 cortical sources. First, the auditory cortex (AC) encodes spectral regularities and reports frequency-specific deviances. Then, more abstract representations in the prefrontal cortex (PFC) allow to detect contextual changes of potential behavioral relevance. However, the precise location and time asynchronies between neuronal correlates underlying this frontotemporal network remain unclear and elusive. Our study presented auditory oddball paradigms along with “no-repetition” controls to record mismatch responses in neuronal spiking activity and local field potentials at the rat medial PFC. Whereas mismatch responses in the auditory system are mainly induced by stimulus-dependent effects, we found that auditory responsiveness in the PFC was driven by unpredictability, yielding context-dependent, comparatively delayed, more robust and longer-lasting mismatch responses mostly comprised of prediction error signaling activity. This characteristically different composition discarded that mismatch responses in the PFC could be simply inherited or amplified downstream from the auditory system. Conversely, it is more plausible for the PFC to exert top-down influences on the AC, since the PFC exhibited flexible and potent predictive processing, capable of suppressing redundant input more efficiently than the AC. Remarkably, the time course of the mismatch responses we observed in the spiking activity and local field potentials of the AC and the PFC combined coincided with the time course of the large-scale MMN-like signals reported in the rat brain, thereby linking the microscopic, mesoscopic, and macroscopic levels of automatic deviance detectionPublic Library of Science (New York, USA)202020202021info:eu-repo/semantics/articlehttp://hdl.handle.net/10366/144481reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésThis project has received funding from the European Union’s Horizon 2020 research andinnovation programme [Marie Skłodowska-Curie Grant agreement No. 722098 (LISTEN)] to MSM; Spanish AEI (PID2019-104570RB-I00) to MSM. DPG held a Postdoctoral salary from the Spanish Ministry of Science and Innovation (MICINN, Grant No. SAF2016-75803-P) Fellowship from the European Union’s Horizon 2020 research and innovation programme [Marie Skłodowska-Curie Grant agreement No. 722098 (LISTEN)] to LCR. Fellowship from the Spanish MICINN (BES-2017- 080030) to GVCAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1444812026-06-07T06:28:51Z
dc.title.none.fl_str_mv Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex
title Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex
spellingShingle Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex
Casado Román, Lorena
Prefrontal cortex
MMN
SSA
Auditory
Prediction error
2490 Neurociencias
title_short Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex
title_full Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex
title_fullStr Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex
title_full_unstemmed Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex
title_sort Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex
dc.creator.none.fl_str_mv Casado Román, Lorena
Carbajal, Guillermo V.
Pérez González, David
Malmierca, Manuel S.
author Casado Román, Lorena
author_facet Casado Román, Lorena
Carbajal, Guillermo V.
Pérez González, David
Malmierca, Manuel S.
author_role author
author2 Carbajal, Guillermo V.
Pérez González, David
Malmierca, Manuel S.
author2_role author
author
author
dc.subject.none.fl_str_mv Prefrontal cortex
MMN
SSA
Auditory
Prediction error
2490 Neurociencias
topic Prefrontal cortex
MMN
SSA
Auditory
Prediction error
2490 Neurociencias
description [EN]The mismatch negativity (MMN) is a key biomarker of automatic deviance detection thought to emerge from 2 cortical sources. First, the auditory cortex (AC) encodes spectral regularities and reports frequency-specific deviances. Then, more abstract representations in the prefrontal cortex (PFC) allow to detect contextual changes of potential behavioral relevance. However, the precise location and time asynchronies between neuronal correlates underlying this frontotemporal network remain unclear and elusive. Our study presented auditory oddball paradigms along with “no-repetition” controls to record mismatch responses in neuronal spiking activity and local field potentials at the rat medial PFC. Whereas mismatch responses in the auditory system are mainly induced by stimulus-dependent effects, we found that auditory responsiveness in the PFC was driven by unpredictability, yielding context-dependent, comparatively delayed, more robust and longer-lasting mismatch responses mostly comprised of prediction error signaling activity. This characteristically different composition discarded that mismatch responses in the PFC could be simply inherited or amplified downstream from the auditory system. Conversely, it is more plausible for the PFC to exert top-down influences on the AC, since the PFC exhibited flexible and potent predictive processing, capable of suppressing redundant input more efficiently than the AC. Remarkably, the time course of the mismatch responses we observed in the spiking activity and local field potentials of the AC and the PFC combined coincided with the time course of the large-scale MMN-like signals reported in the rat brain, thereby linking the microscopic, mesoscopic, and macroscopic levels of automatic deviance detection
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/144481
url http://hdl.handle.net/10366/144481
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv This project has received funding from the European Union’s Horizon 2020 research andinnovation programme [Marie Skłodowska-Curie Grant agreement No. 722098 (LISTEN)] to MSM; Spanish AEI (PID2019-104570RB-I00) to MSM. DPG held a Postdoctoral salary from the Spanish Ministry of Science and Innovation (MICINN, Grant No. SAF2016-75803-P) Fellowship from the European Union’s Horizon 2020 research and innovation programme [Marie Skłodowska-Curie Grant agreement No. 722098 (LISTEN)] to LCR. Fellowship from the Spanish MICINN (BES-2017- 080030) to GVC
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science (New York, USA)
publisher.none.fl_str_mv Public Library of Science (New York, USA)
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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