Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.

Drug-induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion of DILI from 2018 to 2023. A total of 106 patients fulfilled the diagnostic c...

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Authors: Pocurull Aparicio, Anna, Moreta, Maria José, Heitman, David, Olivas Alberch, Ignasi, Collazos Clemente, Cristina, Canga, Elia, Sáez Peñataro, Joaquín, Andrade, Raúl J., Lucena, M. Isabel, Mariño Méndez, Zoe, Diaz Lorca, Maria Alba, Lens García, Sabela, Londoño, María Carlota, Forns, Xavier
Format: article
Status:Versión aceptada para publicación
Publication Date:2024
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/227686
Online Access:https://hdl.handle.net/2445/227686
Access Level:Open access
Keyword:Toxicitat dels medicaments
Malalties del fetge
Medicaments antineoplàstics
Drug toxicity
Liver diseases
Antineoplastic agents
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spelling Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.Pocurull Aparicio, AnnaMoreta, Maria JoséHeitman, DavidOlivas Alberch, IgnasiCollazos Clemente, CristinaCanga, EliaSáez Peñataro, JoaquínAndrade, Raúl J.Lucena, M. IsabelMariño Méndez, ZoeDiaz Lorca, Maria AlbaLens García, SabelaLondoño, María CarlotaForns, XavierToxicitat dels medicamentsMalalties del fetgeMedicaments antineoplàsticsDrug toxicityLiver diseasesAntineoplastic agentsDrug-induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion of DILI from 2018 to 2023. A total of 106 patients fulfilled the diagnostic criteria (30 caused by paracetamol were excluded; total number 76). The pattern of liver injury was hepatocellular in 55 (72%). Drugs causing DILI were antineoplastic (26%), antibiotics (24%), analgesics (12%), and recreational drugs (9%). Regarding clinical outcomes, 39 (51%) required hospitalization and 7 (9%) underwent a liver transplantation or died from acute liver injury. We identified 126 additional patients with DILI due to immune check-point inhibitors who were not referred to a liver disease specialist. Antineoplastic drugs have become the first cause of DILI in hospitals. A multidisciplinary approach and specific educational tools to increase DILI awareness are needed among different specialists.John Wiley & Sons2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/227686Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1111/liv.15821Liver International, 2024, vol. 44, num.2, p. 286-292https://doi.org/10.1111/liv.15821(c) John Wiley & Sons, 2023info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2276862026-05-27T06:46:51Z
dc.title.none.fl_str_mv Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
title Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
spellingShingle Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
Pocurull Aparicio, Anna
Toxicitat dels medicaments
Malalties del fetge
Medicaments antineoplàstics
Drug toxicity
Liver diseases
Antineoplastic agents
title_short Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
title_full Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
title_fullStr Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
title_full_unstemmed Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
title_sort Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
dc.creator.none.fl_str_mv Pocurull Aparicio, Anna
Moreta, Maria José
Heitman, David
Olivas Alberch, Ignasi
Collazos Clemente, Cristina
Canga, Elia
Sáez Peñataro, Joaquín
Andrade, Raúl J.
Lucena, M. Isabel
Mariño Méndez, Zoe
Diaz Lorca, Maria Alba
Lens García, Sabela
Londoño, María Carlota
Forns, Xavier
author Pocurull Aparicio, Anna
author_facet Pocurull Aparicio, Anna
Moreta, Maria José
Heitman, David
Olivas Alberch, Ignasi
Collazos Clemente, Cristina
Canga, Elia
Sáez Peñataro, Joaquín
Andrade, Raúl J.
Lucena, M. Isabel
Mariño Méndez, Zoe
Diaz Lorca, Maria Alba
Lens García, Sabela
Londoño, María Carlota
Forns, Xavier
author_role author
author2 Moreta, Maria José
Heitman, David
Olivas Alberch, Ignasi
Collazos Clemente, Cristina
Canga, Elia
Sáez Peñataro, Joaquín
Andrade, Raúl J.
Lucena, M. Isabel
Mariño Méndez, Zoe
Diaz Lorca, Maria Alba
Lens García, Sabela
Londoño, María Carlota
Forns, Xavier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Toxicitat dels medicaments
Malalties del fetge
Medicaments antineoplàstics
Drug toxicity
Liver diseases
Antineoplastic agents
topic Toxicitat dels medicaments
Malalties del fetge
Medicaments antineoplàstics
Drug toxicity
Liver diseases
Antineoplastic agents
description Drug-induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion of DILI from 2018 to 2023. A total of 106 patients fulfilled the diagnostic criteria (30 caused by paracetamol were excluded; total number 76). The pattern of liver injury was hepatocellular in 55 (72%). Drugs causing DILI were antineoplastic (26%), antibiotics (24%), analgesics (12%), and recreational drugs (9%). Regarding clinical outcomes, 39 (51%) required hospitalization and 7 (9%) underwent a liver transplantation or died from acute liver injury. We identified 126 additional patients with DILI due to immune check-point inhibitors who were not referred to a liver disease specialist. Antineoplastic drugs have become the first cause of DILI in hospitals. A multidisciplinary approach and specific educational tools to increase DILI awareness are needed among different specialists.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/227686
url https://hdl.handle.net/2445/227686
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1111/liv.15821
Liver International, 2024, vol. 44, num.2, p. 286-292
https://doi.org/10.1111/liv.15821
dc.rights.none.fl_str_mv (c) John Wiley & Sons, 2023
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) John Wiley & Sons, 2023
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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