Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate

Drying-induced stabilization is a challenge that delivery systems still face. This study aims to investigate the effects of adding trehalose to spray dried soy-rapeseed lecithin liposomes, and the storage stability of the dried liposomes loaded with a tilapia viscera protein hydrolysate, during 42 d...

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Detalles Bibliográficos
Autores: Sepúlveda, Cindy T., Alemán, Ailén, Zapata, José A., Montero García, Pilar, Gómez Guillén, M. C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/251171
Acceso en línea:http://hdl.handle.net/10261/251171
Access Level:acceso abierto
Palabra clave:Lecithin liposomes
Spray-drying
Trehalose
Fish hydrolysate
Storage stability
In vitro gastrointestinal digestion
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spelling Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysateSepúlveda, Cindy T.Alemán, AilénZapata, José A.Montero García, PilarGómez Guillén, M. C.Lecithin liposomesSpray-dryingTrehaloseFish hydrolysateStorage stabilityIn vitro gastrointestinal digestionDrying-induced stabilization is a challenge that delivery systems still face. This study aims to investigate the effects of adding trehalose to spray dried soy-rapeseed lecithin liposomes, and the storage stability of the dried liposomes loaded with a tilapia viscera protein hydrolysate, during 42 days at 4 °C and 23 °C, and at different relative humidity (RH). Particle size increased from 215 to 250 nm in fresh liposomes to 258–314 nm after spray drying according to trehalose concentration, all preparations showing a strong electronegative ζ Potential (−48.5 to −59.9 mV). Dried liposomes stored at 4 °C maintained lower polydispersity and higher solubility than those stored at 23 °C. Changes in water activity (Aw), FTIR and DSC revealed structural changes in samples stored at 23 °C and high RH. Spray dried hydrolysate-containing liposomes could be considered as a functional food ingredient due to the substantial antioxidant activity and angiotensin-converting enzyme (ACE) inhibitory capacity after in vitro simulated gastrointestinal digestion.[Industrial relevance]: The availability of a natural liposomal preparation in dry powder form, capable to maintain its bioactive properties, is a great advantage for the functional food industry, since it favours the stability, transport and storage of the ingredient prior to use, and allows great versatility to be incorporated in solid restructured products.The authors are grateful for the financial support provided by Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER), through project NANOALIVAL AGL2017-84161; by CSIC through project 202070E218; and by Comité para el Desarrollo de la Investigación en la Universidad de Antioquia (CODI) through sustainability program 2018-2019, COLCIENCIAS (Project 111574558746).Peer reviewedElsevierMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas (España)Colciencias (Colombia)Universidad de AntioquiaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/251171reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-84161-C2-1-Rhttps://doi.org/10.1016/j.ifset.2021.102708Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2511712026-05-22T06:33:51Z
dc.title.none.fl_str_mv Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate
title Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate
spellingShingle Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate
Sepúlveda, Cindy T.
Lecithin liposomes
Spray-drying
Trehalose
Fish hydrolysate
Storage stability
In vitro gastrointestinal digestion
title_short Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate
title_full Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate
title_fullStr Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate
title_full_unstemmed Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate
title_sort Characterization and storage stability of spray dried soy-rapeseed lecithin/trehalose liposomes loaded with a tilapia viscera hydrolysate
dc.creator.none.fl_str_mv Sepúlveda, Cindy T.
Alemán, Ailén
Zapata, José A.
Montero García, Pilar
Gómez Guillén, M. C.
author Sepúlveda, Cindy T.
author_facet Sepúlveda, Cindy T.
Alemán, Ailén
Zapata, José A.
Montero García, Pilar
Gómez Guillén, M. C.
author_role author
author2 Alemán, Ailén
Zapata, José A.
Montero García, Pilar
Gómez Guillén, M. C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
Colciencias (Colombia)
Universidad de Antioquia
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lecithin liposomes
Spray-drying
Trehalose
Fish hydrolysate
Storage stability
In vitro gastrointestinal digestion
topic Lecithin liposomes
Spray-drying
Trehalose
Fish hydrolysate
Storage stability
In vitro gastrointestinal digestion
description Drying-induced stabilization is a challenge that delivery systems still face. This study aims to investigate the effects of adding trehalose to spray dried soy-rapeseed lecithin liposomes, and the storage stability of the dried liposomes loaded with a tilapia viscera protein hydrolysate, during 42 days at 4 °C and 23 °C, and at different relative humidity (RH). Particle size increased from 215 to 250 nm in fresh liposomes to 258–314 nm after spray drying according to trehalose concentration, all preparations showing a strong electronegative ζ Potential (−48.5 to −59.9 mV). Dried liposomes stored at 4 °C maintained lower polydispersity and higher solubility than those stored at 23 °C. Changes in water activity (Aw), FTIR and DSC revealed structural changes in samples stored at 23 °C and high RH. Spray dried hydrolysate-containing liposomes could be considered as a functional food ingredient due to the substantial antioxidant activity and angiotensin-converting enzyme (ACE) inhibitory capacity after in vitro simulated gastrointestinal digestion.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/251171
url http://hdl.handle.net/10261/251171
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-84161-C2-1-R
https://doi.org/10.1016/j.ifset.2021.102708
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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