Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia,...

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Detalhes bibliográficos
Autores: Papadimitriou, Nikos, Dimou, Niki, Tsilidis, Konstantinos K., Banbury, Barbara L., Martin, Richard M., Lewis, Sarah J., Kazmi, Nabila, Robinson, Timothy M., Albanes, Demetrius, Aleksandrova, Krasimira, Berndt, Sonja I., Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Bueno de Mesquita, H. Bas, Campbell, Peter T., Castellví Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Ellingjord-Dale, Merete, Figueiredo, Jane C., Gallinger, Steven, Giles, Graham G., Giovannucci, Edward, Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Harrison, Tabitha A., Hoffmeister, Michael, Hopper, John L., Hsu, Li, Huerta Castaño, José María, Huyghe, Jeroen R., Jenkins, Mark A., Keku, Temitope O., Kühn, Tilman, Vecchia, Carlo La, Marchand, Loïc Le, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Lynch, Brigid M., Markowitz, Sanford D., Masala, Giovanna, May, Anne M., Milne, Roger L., Monninkhof, Evelyn M., Moreno, Lorena, Moreno Aguado, Víctor, Newcomb, Polly A., Offit, Kenneth, Perduca, Vittorio, Pharoah, Paul D. P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Riboli, Elio, Sánchez, María José, Schmit, Stephanie L., Schoen, Robert E., Severi, Gianluca, Sieri, Sabina, Slattery, Martha L., Song, Mingyang, Tangen, Catherine M., Thibodeau, Stephen N., Travis, Ruth C., Trichopoulou, Antonia, Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Van Guelpen, Bethany, Vodicka, Pavel, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Peters, Ulrike, Gunter, Marc J., Murphy, Neil
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2020
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/171811
Acesso em linha:https://hdl.handle.net/2445/171811
Access Level:Acceso aberto
Palavra-chave:Càncer de mama
Càncer colorectal
Condició física
Epidemiologia
Breast cancer
Colorectal cancer
Physical fitness
Epidemiology
Descrição
Resumo:Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.

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