Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study

Apoplexy; Conversion to surgery; Pituitary

Detalles Bibliográficos
Autores: Cordero Asanza, Esteban, Pérez-López, Carlos, Rodríguez Berrocal, Víctor, VICENTE , ALMUDENA, Sánchez Ramirez, María Noelia, Biagetti, Betina, Lamas Oliveira, Cristina, Martinez-Saez, Elena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/13267
Acceso en línea:http://hdl.handle.net/11351/13267
Access Level:acceso abierto
Palabra clave:Malalties cerebrovasculars - Tractament
Malalties cerebrovasculars - Cirurgia
Hipòfisi
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary Apoplexy
Other subheadings::Other subheadings::/therapy
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Conservative Treatment
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisaria
Otros calificadores::Otros calificadores::/terapia
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::tratamiento conservador
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oai_identifier_str oai:recercat.cat:11351/13267
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
title Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
spellingShingle Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
Cordero Asanza, Esteban
Malalties cerebrovasculars - Tractament
Malalties cerebrovasculars - Cirurgia
Hipòfisi
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary Apoplexy
Other subheadings::Other subheadings::/therapy
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary Apoplexy
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Conservative Treatment
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisaria
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisaria
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::tratamiento conservador
title_short Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
title_full Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
title_fullStr Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
title_full_unstemmed Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
title_sort Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
dc.creator.none.fl_str_mv Cordero Asanza, Esteban
Pérez-López, Carlos
Rodríguez Berrocal, Víctor
VICENTE , ALMUDENA
Sánchez Ramirez, María Noelia
Biagetti, Betina
Lamas Oliveira, Cristina
Martinez-Saez, Elena
author Cordero Asanza, Esteban
author_facet Cordero Asanza, Esteban
Pérez-López, Carlos
Rodríguez Berrocal, Víctor
VICENTE , ALMUDENA
Sánchez Ramirez, María Noelia
Biagetti, Betina
Lamas Oliveira, Cristina
Martinez-Saez, Elena
author_role author
author2 Pérez-López, Carlos
Rodríguez Berrocal, Víctor
VICENTE , ALMUDENA
Sánchez Ramirez, María Noelia
Biagetti, Betina
Lamas Oliveira, Cristina
Martinez-Saez, Elena
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Biagetti B] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERER U747 (ISCIII), ENDO-ERN, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Cordero Asanza E, Sánchez Ramirez MN] Servei de Neurocirurgia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Cirurgia i Ciències Morfològiques, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Pérez-López C] Department of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain. Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rodríguez Berrocal V] Department of Neurosurgery, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Vicente A] Endocrinology & Nutrition Department, Hospital Universitario de Toledo, Toledo, Spain. [Lamas C] Endocrinology & Nutrition Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. [Martinez-Saez E] Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Malalties cerebrovasculars - Tractament
Malalties cerebrovasculars - Cirurgia
Hipòfisi
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary Apoplexy
Other subheadings::Other subheadings::/therapy
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary Apoplexy
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Conservative Treatment
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisaria
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisaria
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::tratamiento conservador
topic Malalties cerebrovasculars - Tractament
Malalties cerebrovasculars - Cirurgia
Hipòfisi
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary Apoplexy
Other subheadings::Other subheadings::/therapy
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary Apoplexy
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Conservative Treatment
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisaria
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisaria
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::tratamiento conservador
description Apoplexy; Conversion to surgery; Pituitary
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11351/13267
http://hdl.handle.net/11351/13267
url http://hdl.handle.net/11351/13267
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical & Translational Endocrinology;40
https://doi.org/10.1016/j.jcte.2025.100399
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational studyCordero Asanza, EstebanPérez-López, CarlosRodríguez Berrocal, VíctorVICENTE , ALMUDENASánchez Ramirez, María NoeliaBiagetti, BetinaLamas Oliveira, CristinaMartinez-Saez, ElenaMalalties cerebrovasculars - TractamentMalalties cerebrovasculars - CirurgiaHipòfisiDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary ApoplexyOther subheadings::Other subheadings::/therapyDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Pituitary ApoplexyOther subheadings::Other subheadings::Other subheadings::/surgeryANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Conservative TreatmentENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisariaOtros calificadores::Otros calificadores::/terapiaENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::hemorragias intracraneales::apoplejía hipofisariaOtros calificadores::Otros calificadores::Otros calificadores::/cirugíaTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::tratamiento conservadorApoplexy; Conversion to surgery; PituitaryApoplexia; Conversió a cirurgia; HipòfisiApoplejía; Conversión a cirugía; HipófisisBackground Pituitary apoplexy (PA) is a rare but potentially life-threatening condition. While conservative management is an option in selected cases, predictors of conversion to surgery after initial conservative management remain unclear. Objective To identify predictors of transitioning to surgery in PA who were initially managed conservatively, and to assess the timing and impact of surgical conversion. Methods This multicenter observational study included 134 patients with PA initially managed conservatively. Patients were categorized into successful conservative management (no surgery or surgery scheduled after 30 days) and conversion to surgery (surgery within 8–30 days). Logistic and Cox regression analyses were performed to identify predictors of conversion to surgery and time to transition, respectively. Results Among the 134 patients enrolled, the median age was 61.4 years (interquartile range: 16.0) years and 93 (69.4 %) men], 69 (51.5 %) ultimately required surgery, with most transitions occurring within the first two weeks. In logistic regression analysis, larger tumor size (OR: 1.09, 95 % CI: 1.02–1.16) and higher BMI (OR: 1.11, 95 % CI: 1.01–1.22) were independently associated with conversion to surgery. However, Cox regression did not identify any variables predicting time to transition. Additionally, patients who converted to surgery had a significantly longer hospital stay (21.0 vs. 7.5 days, p < 0.01). Conclusion Half of the patients initially managed conservatively required convertion to surgery. Tumor size and BMI were associated with an increased likelihood of surgery, but no factors predicted when surgery would occur, suggesting that the decision to conversion to surgery may be influenced by multiple clinical factors rather than a single determinant.ElsevierInstitut Català de la Salut[Biagetti B] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERER U747 (ISCIII), ENDO-ERN, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Cordero Asanza E, Sánchez Ramirez MN] Servei de Neurocirurgia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Cirurgia i Ciències Morfològiques, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Pérez-López C] Department of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain. Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rodríguez Berrocal V] Department of Neurosurgery, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Vicente A] Endocrinology & Nutrition Department, Hospital Universitario de Toledo, Toledo, Spain. [Lamas C] Endocrinology & Nutrition Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. [Martinez-Saez E] Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13267http://hdl.handle.net/11351/13267Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Clinical & Translational Endocrinology;40https://doi.org/10.1016/j.jcte.2025.100399Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/132672026-05-29T05:05:01Z
score 15,812429

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