Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials

Implantable electrodes act with direct electrical contact although recent work has shown that electrostimulation is also possible through non-contact wireless settings, through the generation of dipoles at the borders of the material by bipolar electrochemistry. The experimental observations with ne...

Descripción completa

Detalles Bibliográficos
Autores: Abad Muñoz, Llibertat, Rajnicek, Ann M., Casañ Pastor, Nieves
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/202756
Acceso en línea:http://hdl.handle.net/10261/202756
Access Level:acceso abierto
Palabra clave:Electric gradients
Neural electrodes
Charge asymmetry
Finite elements
Electroactive materials
Implants
id ES_886382e941fa98f9ddacce255d6d5d3d
oai_identifier_str oai:digital.csic.es:10261/202756
network_acronym_str ES
network_name_str España
repository_id_str
spelling Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materialsAbad Muñoz, LlibertatRajnicek, Ann M.Casañ Pastor, NievesElectric gradientsNeural electrodesCharge asymmetryFinite elementsElectroactive materialsImplantsImplantable electrodes act with direct electrical contact although recent work has shown that electrostimulation is also possible through non-contact wireless settings, through the generation of dipoles at the borders of the material by bipolar electrochemistry. The experimental observations with neural cell cultures demonstrate a clear difference between insulator and conducting materials, but also between conducting and mixed conducting intercalation materials used as substrates of neural growth. Known bipolar electrochemistry effects may explain voltage profiles induced on conducting materials. Finite element studies shown here with the same configuration that the experimental processes described, evidence voltage profiles in qualitative agreement with known bipolar effects, although with a clear difference between intercalation materials and metals. Calculations also show a clear mapping of charge gradients at the material surface influencing growing neurons cells. While insulating materials only distort the electric field space distribution, the dipole generated at the borders of an implanted conducting material, inverted with respect to the insulating case, extends along the material interface, being relevant that is much smoother in intercalation materials. Mapping of the gradients as the distance is increased from the conducting material is also discussed. These observations may explain the differences in neural cell growth observed for various substrate materials.This work was funded by the European Commission FP6 NEST Program (Contract 028473), RTI2018-097753, MAT2011-24363 and MAT2015-65192-R from the Spanish Science Ministry, La Marató de TV3 Foundation (Identification Number 110131), and Severo Ochoa Programme for Centres of Excellence in R&D (SEV-2015-0496). LI. Abad thanks MINECO for a Ramón y Cajal Contract (RYC-2013-12640). The authors also thank A. Beardo (NanoTransport group from UAB) for useful discussions.Peer reviewedElsevierEuropean CommissionMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Fundació La Marató de TV3Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/202756reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#MICIU/ICTI2017-2020/RTI2018-097753-B-I00info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-65192-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0496http://dx.doi.org/10.1016/j.electacta.2019.05.149Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2027562026-05-22T06:33:51Z
dc.title.none.fl_str_mv Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials
title Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials
spellingShingle Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials
Abad Muñoz, Llibertat
Electric gradients
Neural electrodes
Charge asymmetry
Finite elements
Electroactive materials
Implants
title_short Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials
title_full Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials
title_fullStr Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials
title_full_unstemmed Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials
title_sort Electric field gradients and bipolar electrochemistry effects on neural growth: A finite element study on immersed electroactive conducting electrode materials
dc.creator.none.fl_str_mv Abad Muñoz, Llibertat
Rajnicek, Ann M.
Casañ Pastor, Nieves
author Abad Muñoz, Llibertat
author_facet Abad Muñoz, Llibertat
Rajnicek, Ann M.
Casañ Pastor, Nieves
author_role author
author2 Rajnicek, Ann M.
Casañ Pastor, Nieves
author2_role author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Fundació La Marató de TV3
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Electric gradients
Neural electrodes
Charge asymmetry
Finite elements
Electroactive materials
Implants
topic Electric gradients
Neural electrodes
Charge asymmetry
Finite elements
Electroactive materials
Implants
description Implantable electrodes act with direct electrical contact although recent work has shown that electrostimulation is also possible through non-contact wireless settings, through the generation of dipoles at the borders of the material by bipolar electrochemistry. The experimental observations with neural cell cultures demonstrate a clear difference between insulator and conducting materials, but also between conducting and mixed conducting intercalation materials used as substrates of neural growth. Known bipolar electrochemistry effects may explain voltage profiles induced on conducting materials. Finite element studies shown here with the same configuration that the experimental processes described, evidence voltage profiles in qualitative agreement with known bipolar effects, although with a clear difference between intercalation materials and metals. Calculations also show a clear mapping of charge gradients at the material surface influencing growing neurons cells. While insulating materials only distort the electric field space distribution, the dipole generated at the borders of an implanted conducting material, inverted with respect to the insulating case, extends along the material interface, being relevant that is much smoother in intercalation materials. Mapping of the gradients as the distance is increased from the conducting material is also discussed. These observations may explain the differences in neural cell growth observed for various substrate materials.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/202756
url http://hdl.handle.net/10261/202756
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
MICIU/ICTI2017-2020/RTI2018-097753-B-I00
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-65192-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0496
http://dx.doi.org/10.1016/j.electacta.2019.05.149
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412548098392064
score 15,812429

Similares en LA Referencia