A straightforward synthesis of 5′-peptide oligonucleotide conjugates using Nα-Fmoc-protected amino acids
(Chemical Equation Presented) 5′-Peptide oligonucleotide conjugates were prepared stepwise on a single support using Nα-Fmoc- protected amino acids and unprotected phosphate groups. The method uses commercially available reagents and is successful with most natural amino acids. The simplicity of the...
| Autores: | , , , , |
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| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2005 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/124874 |
| Acesso em linha: | http://hdl.handle.net/10261/124874 |
| Access Level: | acceso abierto |
| Palavra-chave: | fluorene derivative Amino acid oligonucleotides Fluorene chemical structure |
| Resumo: | (Chemical Equation Presented) 5′-Peptide oligonucleotide conjugates were prepared stepwise on a single support using Nα-Fmoc- protected amino acids and unprotected phosphate groups. The method uses commercially available reagents and is successful with most natural amino acids. The simplicity of the method may encourage researchers to prepare new oligonucleotide-peptide conjugates with novel properties. |
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