Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)

The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important swine diseases in the world. It is causing an enormous economic burden due to reproductive failure in sows and a complex respiratory syndrome in pigs of all ages, with mortality varying from 2 to 100% in the...

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Detalhes bibliográficos
Autores: Montaner Tarbes, Sergio Roberto, Portillo Obando, Hernando A. del, Montoya, María, Fraile Sauce, Lorenzo José
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/66370
Acesso em linha:https://doi.org/10.3389/fvets.2019.00038
http://hdl.handle.net/10459.1/66370
Access Level:acceso abierto
Palavra-chave:Porcine reproductive and respiratory syndrome virus
PRRSV
Virus biology
Immunology
Vaccinology
Extracellular vesicles
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spelling Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)Montaner Tarbes, Sergio RobertoPortillo Obando, Hernando A. delMontoya, MaríaFraile Sauce, Lorenzo JoséPorcine reproductive and respiratory syndrome virusPRRSVVirus biologyImmunologyVaccinologyExtracellular vesiclesThe porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important swine diseases in the world. It is causing an enormous economic burden due to reproductive failure in sows and a complex respiratory syndrome in pigs of all ages, with mortality varying from 2 to 100% in the most extreme cases of emergent highly pathogenic strains. PRRSV displays complex interactions with the immune system and a high mutation rate, making the development, and implementation of control strategies a major challenge. In this review, the biology of the virus will be addressed focusing on newly discovered functions of non-structural proteins and novel dissemination mechanisms. Secondly, the role of different cell types and viral proteins will be reviewed in natural and vaccine-induced immune response together with the role of different immune evasion mechanisms focusing on those gaps of knowledge that are critical to generate more efficacious vaccines. Finally, novel strategies for antigen discovery and vaccine development will be discussed, in particular the use of exosomes (extracellular vesicles of endocytic origin). As nanocarriers of lipids, proteins and nucleic acids, exosomes have potential effects on cell activation, modulation of immune responses and antigen presentation. Thus, representing a novel vaccination approach against this devastating disease.SM-T is an industrial doctorate awarded by the Government of Catalonia, Spain (No. 2014 DI 044). This review received support from the FEDER project (COMRDI16-1-0035-03).Frontiers Media201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3389/fvets.2019.00038http://hdl.handle.net/10459.1/66370http://hdl.handle.net/10459.1/66370reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.3389/fvets.2019.00038Frontiers in Veterinary Science, 2019, vol. 6, article 38, 15 ppcc-by (c) Sergio Montaner-Tarbes et al., 2019info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/663702026-05-29T05:05:01Z
dc.title.none.fl_str_mv Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
title Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
spellingShingle Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
Montaner Tarbes, Sergio Roberto
Porcine reproductive and respiratory syndrome virus
PRRSV
Virus biology
Immunology
Vaccinology
Extracellular vesicles
title_short Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
title_full Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
title_fullStr Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
title_full_unstemmed Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
title_sort Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
dc.creator.none.fl_str_mv Montaner Tarbes, Sergio Roberto
Portillo Obando, Hernando A. del
Montoya, María
Fraile Sauce, Lorenzo José
author Montaner Tarbes, Sergio Roberto
author_facet Montaner Tarbes, Sergio Roberto
Portillo Obando, Hernando A. del
Montoya, María
Fraile Sauce, Lorenzo José
author_role author
author2 Portillo Obando, Hernando A. del
Montoya, María
Fraile Sauce, Lorenzo José
author2_role author
author
author
dc.subject.none.fl_str_mv Porcine reproductive and respiratory syndrome virus
PRRSV
Virus biology
Immunology
Vaccinology
Extracellular vesicles
topic Porcine reproductive and respiratory syndrome virus
PRRSV
Virus biology
Immunology
Vaccinology
Extracellular vesicles
description The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important swine diseases in the world. It is causing an enormous economic burden due to reproductive failure in sows and a complex respiratory syndrome in pigs of all ages, with mortality varying from 2 to 100% in the most extreme cases of emergent highly pathogenic strains. PRRSV displays complex interactions with the immune system and a high mutation rate, making the development, and implementation of control strategies a major challenge. In this review, the biology of the virus will be addressed focusing on newly discovered functions of non-structural proteins and novel dissemination mechanisms. Secondly, the role of different cell types and viral proteins will be reviewed in natural and vaccine-induced immune response together with the role of different immune evasion mechanisms focusing on those gaps of knowledge that are critical to generate more efficacious vaccines. Finally, novel strategies for antigen discovery and vaccine development will be discussed, in particular the use of exosomes (extracellular vesicles of endocytic origin). As nanocarriers of lipids, proteins and nucleic acids, exosomes have potential effects on cell activation, modulation of immune responses and antigen presentation. Thus, representing a novel vaccination approach against this devastating disease.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3389/fvets.2019.00038
http://hdl.handle.net/10459.1/66370
http://hdl.handle.net/10459.1/66370
url https://doi.org/10.3389/fvets.2019.00038
http://hdl.handle.net/10459.1/66370
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3389/fvets.2019.00038
Frontiers in Veterinary Science, 2019, vol. 6, article 38, 15 pp
dc.rights.none.fl_str_mv cc-by (c) Sergio Montaner-Tarbes et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Sergio Montaner-Tarbes et al., 2019
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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