The multiple roles of the Cdc14 phosphatase in cell cycle control

This article belongs to the Special Issue Protein Phosphatases and Cell Cycle Regulation in Yeasts.

Detalles Bibliográficos
Autores: Manzano-López, Javier, Monje-Casas, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/221284
Acceso en línea:http://hdl.handle.net/10261/221284
Access Level:acceso abierto
Palabra clave:Cdc14
Cytokinesis
Phosphatase
Autophagy
Mitotic exit
Genome stability
Nucleolus
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spelling The multiple roles of the Cdc14 phosphatase in cell cycle controlManzano-López, JavierMonje-Casas, FernandoCdc14CytokinesisPhosphataseAutophagyMitotic exitGenome stabilityNucleolusThis article belongs to the Special Issue Protein Phosphatases and Cell Cycle Regulation in Yeasts.The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase.This research was funded by the European Union (FEDER) and the Spanish Ministry of Economy, Industry and Competitiveness (BFU2016-76642-P grant and IJCI-2017-33087 Juan de la Cierva research contract to Javier Manzano).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/221284reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-76642-Pinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/IJCI-2017-33087IJCI-2017-33087/AEI/10.13039/501100011033https://doi.org/10.3390/ijms21030709Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2212842026-05-22T06:33:51Z
dc.title.none.fl_str_mv The multiple roles of the Cdc14 phosphatase in cell cycle control
title The multiple roles of the Cdc14 phosphatase in cell cycle control
spellingShingle The multiple roles of the Cdc14 phosphatase in cell cycle control
Manzano-López, Javier
Cdc14
Cytokinesis
Phosphatase
Autophagy
Mitotic exit
Genome stability
Nucleolus
title_short The multiple roles of the Cdc14 phosphatase in cell cycle control
title_full The multiple roles of the Cdc14 phosphatase in cell cycle control
title_fullStr The multiple roles of the Cdc14 phosphatase in cell cycle control
title_full_unstemmed The multiple roles of the Cdc14 phosphatase in cell cycle control
title_sort The multiple roles of the Cdc14 phosphatase in cell cycle control
dc.creator.none.fl_str_mv Manzano-López, Javier
Monje-Casas, Fernando
author Manzano-López, Javier
author_facet Manzano-López, Javier
Monje-Casas, Fernando
author_role author
author2 Monje-Casas, Fernando
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cdc14
Cytokinesis
Phosphatase
Autophagy
Mitotic exit
Genome stability
Nucleolus
topic Cdc14
Cytokinesis
Phosphatase
Autophagy
Mitotic exit
Genome stability
Nucleolus
description This article belongs to the Special Issue Protein Phosphatases and Cell Cycle Regulation in Yeasts.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/221284
url http://hdl.handle.net/10261/221284
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-76642-P
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/IJCI-2017-33087
IJCI-2017-33087/AEI/10.13039/501100011033
https://doi.org/10.3390/ijms21030709
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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