Role of aquaporins in cell proliferation: What else beyond water permeability?

In addition to the extensive data demonstrating the importance of mammalian AQPs for the movement of water and some small solutes across the cell membrane, there is now a growing body of evidence indicating the involvement of these proteins in numerous cellular processes seemingly unrelated, at leas...

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Detalhes bibliográficos
Autores: Galán-Cobo, Ana, Ramírez Lorca, Reposo, Echevarría Irusta, Miriam
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Universidad de Sevilla (US)
Repositório:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/114923
Acesso em linha:https://hdl.handle.net/11441/114923
https://doi.org/10.1080/19336950.2016.1139250
Access Level:Acceso aberto
Palavra-chave:Cell cycle
Cell proliferation
Gene expression
Glycerol
Hydrogen peroxide permeability
Neurogenic niche
Aquaporins (AQPs)
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repository_id_str
spelling Role of aquaporins in cell proliferation: What else beyond water permeability?Galán-Cobo, AnaRamírez Lorca, ReposoEchevarría Irusta, MiriamCell cycleCell proliferationGene expressionGlycerolHydrogen peroxide permeabilityNeurogenic nicheAquaporins (AQPs)In addition to the extensive data demonstrating the importance of mammalian AQPs for the movement of water and some small solutes across the cell membrane, there is now a growing body of evidence indicating the involvement of these proteins in numerous cellular processes seemingly unrelated, at least some of them in a direct way, to their canonical function of water permeation. Here, we have presented a broad range of evidence demonstrating that these proteins have a role in cell proliferation by various different mechanisms, namely, by allowing fast cell volume regulation during cell division; by affecting progression of cell cycle and helping maintain the balance between proliferation and apoptosis, and by crosstalk with other cell membrane proteins or transcription factors that, in turn, modulate progression of the cell cycle or regulate biosynthesis pathways of cell structural components. In the end, however, after discussing all these data that strongly support a role for AQPs in the cell proliferation process, it remains impossible to conclude that all these other functions attributed to AQPs occur completely independently of their water permeability, and there is a need for new experiments designed specifically to address this interesting issue.Carlos III Health Institute (Ref. PI12/01882)Regional Department of Health (PI 0018-2014)Taylor & Francis Open AccessFisiología Médica y Biofísica2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/114923https://doi.org/10.1080/19336950.2016.1139250reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésChannels, 10 (3), 185-201.Ref. PI12/01882PI 0018-2014https://www.tandfonline.com/doi/full/10.1080/19336950.2016.1139250info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1149232026-06-17T12:51:07Z
dc.title.none.fl_str_mv Role of aquaporins in cell proliferation: What else beyond water permeability?
title Role of aquaporins in cell proliferation: What else beyond water permeability?
spellingShingle Role of aquaporins in cell proliferation: What else beyond water permeability?
Galán-Cobo, Ana
Cell cycle
Cell proliferation
Gene expression
Glycerol
Hydrogen peroxide permeability
Neurogenic niche
Aquaporins (AQPs)
title_short Role of aquaporins in cell proliferation: What else beyond water permeability?
title_full Role of aquaporins in cell proliferation: What else beyond water permeability?
title_fullStr Role of aquaporins in cell proliferation: What else beyond water permeability?
title_full_unstemmed Role of aquaporins in cell proliferation: What else beyond water permeability?
title_sort Role of aquaporins in cell proliferation: What else beyond water permeability?
dc.creator.none.fl_str_mv Galán-Cobo, Ana
Ramírez Lorca, Reposo
Echevarría Irusta, Miriam
author Galán-Cobo, Ana
author_facet Galán-Cobo, Ana
Ramírez Lorca, Reposo
Echevarría Irusta, Miriam
author_role author
author2 Ramírez Lorca, Reposo
Echevarría Irusta, Miriam
author2_role author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
dc.subject.none.fl_str_mv Cell cycle
Cell proliferation
Gene expression
Glycerol
Hydrogen peroxide permeability
Neurogenic niche
Aquaporins (AQPs)
topic Cell cycle
Cell proliferation
Gene expression
Glycerol
Hydrogen peroxide permeability
Neurogenic niche
Aquaporins (AQPs)
description In addition to the extensive data demonstrating the importance of mammalian AQPs for the movement of water and some small solutes across the cell membrane, there is now a growing body of evidence indicating the involvement of these proteins in numerous cellular processes seemingly unrelated, at least some of them in a direct way, to their canonical function of water permeation. Here, we have presented a broad range of evidence demonstrating that these proteins have a role in cell proliferation by various different mechanisms, namely, by allowing fast cell volume regulation during cell division; by affecting progression of cell cycle and helping maintain the balance between proliferation and apoptosis, and by crosstalk with other cell membrane proteins or transcription factors that, in turn, modulate progression of the cell cycle or regulate biosynthesis pathways of cell structural components. In the end, however, after discussing all these data that strongly support a role for AQPs in the cell proliferation process, it remains impossible to conclude that all these other functions attributed to AQPs occur completely independently of their water permeability, and there is a need for new experiments designed specifically to address this interesting issue.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/114923
https://doi.org/10.1080/19336950.2016.1139250
url https://hdl.handle.net/11441/114923
https://doi.org/10.1080/19336950.2016.1139250
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Channels, 10 (3), 185-201.
Ref. PI12/01882
PI 0018-2014
https://www.tandfonline.com/doi/full/10.1080/19336950.2016.1139250
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Open Access
publisher.none.fl_str_mv Taylor & Francis Open Access
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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