Feasibility of resistance training in adult McArdle patients: clinical outcomes and muscle strength and mass benefits

We analyzed the effects of a 4-month resistance (weight lifting) training program followed by a 2-month detraining period in 7 adult McArdle patients (5 female) on: muscle mass (assessed by DXA), strength, serum creatine kinase (CK) activity and clinical severity. Adherence to training was ≥84% in a...

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Detalhes bibliográficos
Autores: Santalla Hernández, Alfredo, Munguía-Izquierdo, Diego, Brea Alejo, Lidia, Pagola Aldazabal, Itziar, Díez Bermejo, Jorge, Fleck, Steven J., Ara, Ignacio, Lucía Mulas, Alejandro
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/4003
Acesso em linha:http://hdl.handle.net/11268/4003
Access Level:acceso abierto
Palavra-chave:Rhabdomyolysis
Muscle atrophy
Muscle weakness
Glycogenosis
Enfermedades - McArdle
Ejercicio físico
Genética
Salud
Ciencia
Descrição
Resumo:We analyzed the effects of a 4-month resistance (weight lifting) training program followed by a 2-month detraining period in 7 adult McArdle patients (5 female) on: muscle mass (assessed by DXA), strength, serum creatine kinase (CK) activity and clinical severity. Adherence to training was ≥84% in all patients and no major contraindication or side effect was noted during the training or strength assessment sessions. The training program had a significant impact on total and lower extremities' lean mass (P < 0.05 for the time effect), with mean values increasing with training by +855 g (95% confidence interval (CI): 30, 1679) and +547 g (95%CI: 116, 978), respectively, and significantly decreasing with detraining.