Atomic Neural Network for Calculation of Solvation Free Energies in Organic Solvents

This paper introduces AtomicESE, an artificial neural network for calculating solvation-free energies ΔG°solv of molecules in organic solvents. AtomicESE calculates ΔG°solv by summing atomic contributions, each evaluated by a dense neural network. This atomic network uses 13 physically relevant inpu...

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Detalles Bibliográficos
Autor: Vyboishchikov, Sergei F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/27275
Acceso en línea:http://hdl.handle.net/10256/27275
Access Level:acceso abierto
Palabra clave:Solvatació
Solvation
Descripción
Sumario:This paper introduces AtomicESE, an artificial neural network for calculating solvation-free energies ΔG°solv of molecules in organic solvents. AtomicESE calculates ΔG°solv by summing atomic contributions, each evaluated by a dense neural network. This atomic network uses 13 physically relevant input features, comprising six local atomic features, two global charge-related molecular properties, and five solvent-specific properties. For neutral solutes, AtomicESE achieves an average RMSE below 0.6 kcal/mol, demonstrating strong performance across all solvent classes, with particularly high accuracy for aromatic, haloaromatic, alkane, and ketone solvents. AtomicESE also works reliably for ionic solutes