Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

Koster, R. (Roelof)|||/items/36649332-0f02-4645-a4c7-e0c5021e0786; Panagiotou, O.A. (Orestis A.)|||/items/8d4d5996-23e7-436c-9ea4-3b21ff54ee51; Wheeler, W. (William)|||/items/83edd778-ee3d-461d-8efd-d5e8298ea183; Karlins, E. (Eric)|||/items/facb693a-cefc-4d9b-a952-b953e243ee34; Gastier-Foster, J.M. (Julie M.)|||/items/9468165c-c674-4c9d-9a3c-e94a64e7f2a8; Caminada-de-Toledo, S.R. (Silvia Regina)|||/items/5a35bb13-2e22-4729-9fbd-b46e6f60f707; Petrilli, A.S. (Antonio S.)|||/items/37244261-c18e-4e91-9767-4cce329cec98; Flanagan, A.M. (Adrienne M.)|||/items/0443ec23-fe6a-49ed-87ae-1ff2e49e39f0; Tirabosco, R. (Roberto)|||/items/dcca7576-36b5-4650-bd3e-e0d1cec1a35f; Andrulis, I.L. (Irene L.)|||/items/d69f2ad8-1f3a-48ea-9d4b-d494c894a037; Wunder, J.S. (Jay S.)|||/items/a8d4ddc7-21fe-455a-8d40-a78285b7a4df; Gokgoz, N. (Nalan)|||/items/d473d928-06b3-4983-b514-3930b03ae61f; Patiño-García, A. (Ana)|||/items/d68c74f1-df22-4e04-9b77-9cf48fd87b46; Lecanda, F. (Fernando)|||/items/3fac5441-504d-4927-979a-5460140b12ec; Serra, M. (Massimo)|||/items/c8910a1b-27ca-4c3b-9269-d0428639586b; Hattinger, C. (Claudia)|||/items/8941a946-d617-40bd-a72c-702c43e68519; Picci, P. (Piero)|||/items/de3a871f-f41e-4985-981d-13b86c7998b3; Scotlandi, K. (Katia)|||/items/ed376d03-a408-4ba6-8042-eea14f5b1ee7; Thomas, D.M. (David M.)|||/items/dbed693a-f378-42be-8e16-3f7a1b513041; Ballinger, M.L. (Mandy L.)|||/items/22927a92-fc4b-4b0e-ab5d-e2a0142255be; Gorlick, R.G. (Richard G.)|||/items/81f87e34-37fd-40b9-b4e9-bd17cbff954d; Barkauskas, D.A. (Donald A.)|||/items/95137ff6-0a3f-4546-8844-f3461e0b2b20; Spector, L. (Logan)|||/items/26e3e4de-dc41-4f41-848a-11f348546e18; Tucker, M. (Margaret)|||/items/cd38ecc3-c72b-4ddf-b57a-f07f5e772cc8; Hicks, B. (Belynda)|||/items/7c7b8bf7-59a6-43fa-bc23-5ebb6ca20ed4; Yeager, M. (Meredith)|||/items/ba948e8b-ad2a-42a8-a20e-8edbc3a7873b; Hoover, R.N. (Robert N.)|||/items/c70b6d66-dd1b-4bb3-9744-fd09272edc93; Wacholder, S. (Sholom)|||/items/cd3a62c1-0ac4-4b6a-8514-19ffb6cdf2b8; Chanock, S.J. (Stephen J.)|||/items/831081e7-45d2-40ad-826a-84127a3c895b; Savage, S.A. (Sharon A.)|||/items/cd3f20bc-c3cd-4bcc-86ff-f94854e8d464; Mirabello, L. (Lisa)|||/items/5874a672-c4aa-4c41-81a9-43de48bab763

Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associate...

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Detalles Bibliográficos
Autores:	Koster, R. (Roelof)\|\|\|/items/36649332-0f02-4645-a4c7-e0c5021e0786, Panagiotou, O.A. (Orestis A.)\|\|\|/items/8d4d5996-23e7-436c-9ea4-3b21ff54ee51, Wheeler, W. (William)\|\|\|/items/83edd778-ee3d-461d-8efd-d5e8298ea183, Karlins, E. (Eric)\|\|\|/items/facb693a-cefc-4d9b-a952-b953e243ee34, Gastier-Foster, J.M. (Julie M.)\|\|\|/items/9468165c-c674-4c9d-9a3c-e94a64e7f2a8, Caminada-de-Toledo, S.R. (Silvia Regina)\|\|\|/items/5a35bb13-2e22-4729-9fbd-b46e6f60f707, Petrilli, A.S. (Antonio S.)\|\|\|/items/37244261-c18e-4e91-9767-4cce329cec98, Flanagan, A.M. (Adrienne M.)\|\|\|/items/0443ec23-fe6a-49ed-87ae-1ff2e49e39f0, Tirabosco, R. (Roberto)\|\|\|/items/dcca7576-36b5-4650-bd3e-e0d1cec1a35f, Andrulis, I.L. (Irene L.)\|\|\|/items/d69f2ad8-1f3a-48ea-9d4b-d494c894a037, Wunder, J.S. (Jay S.)\|\|\|/items/a8d4ddc7-21fe-455a-8d40-a78285b7a4df, Gokgoz, N. (Nalan)\|\|\|/items/d473d928-06b3-4983-b514-3930b03ae61f, Patiño-García, A. (Ana)\|\|\|/items/d68c74f1-df22-4e04-9b77-9cf48fd87b46, Lecanda, F. (Fernando)\|\|\|/items/3fac5441-504d-4927-979a-5460140b12ec, Serra, M. (Massimo)\|\|\|/items/c8910a1b-27ca-4c3b-9269-d0428639586b, Hattinger, C. (Claudia)\|\|\|/items/8941a946-d617-40bd-a72c-702c43e68519, Picci, P. (Piero)\|\|\|/items/de3a871f-f41e-4985-981d-13b86c7998b3, Scotlandi, K. (Katia)\|\|\|/items/ed376d03-a408-4ba6-8042-eea14f5b1ee7, Thomas, D.M. (David M.)\|\|\|/items/dbed693a-f378-42be-8e16-3f7a1b513041, Ballinger, M.L. (Mandy L.)\|\|\|/items/22927a92-fc4b-4b0e-ab5d-e2a0142255be, Gorlick, R.G. (Richard G.)\|\|\|/items/81f87e34-37fd-40b9-b4e9-bd17cbff954d, Barkauskas, D.A. (Donald A.)\|\|\|/items/95137ff6-0a3f-4546-8844-f3461e0b2b20, Spector, L. (Logan)\|\|\|/items/26e3e4de-dc41-4f41-848a-11f348546e18, Tucker, M. (Margaret)\|\|\|/items/cd38ecc3-c72b-4ddf-b57a-f07f5e772cc8, Hicks, B. (Belynda)\|\|\|/items/7c7b8bf7-59a6-43fa-bc23-5ebb6ca20ed4, Yeager, M. (Meredith)\|\|\|/items/ba948e8b-ad2a-42a8-a20e-8edbc3a7873b, Hoover, R.N. (Robert N.)\|\|\|/items/c70b6d66-dd1b-4bb3-9744-fd09272edc93, Wacholder, S. (Sholom)\|\|\|/items/cd3a62c1-0ac4-4b6a-8514-19ffb6cdf2b8, Chanock, S.J. (Stephen J.)\|\|\|/items/831081e7-45d2-40ad-826a-84127a3c895b, Savage, S.A. (Sharon A.)\|\|\|/items/cd3f20bc-c3cd-4bcc-86ff-f94854e8d464, Mirabello, L. (Lisa)\|\|\|/items/5874a672-c4aa-4c41-81a9-43de48bab763
Tipo de recurso:	artículo
Fecha de publicación:	2018
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/65525
Acceso en línea:	https://hdl.handle.net/10171/65525
Access Level:	acceso abierto
Palabra clave:	Osteosarcoma Overall survival Genome-wide association study Osteosarcoma-specific survival

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repository_id_str
spelling	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patientsKoster, R. (Roelof)\|\|\|/items/36649332-0f02-4645-a4c7-e0c5021e0786Panagiotou, O.A. (Orestis A.)\|\|\|/items/8d4d5996-23e7-436c-9ea4-3b21ff54ee51Wheeler, W. (William)\|\|\|/items/83edd778-ee3d-461d-8efd-d5e8298ea183Karlins, E. (Eric)\|\|\|/items/facb693a-cefc-4d9b-a952-b953e243ee34Gastier-Foster, J.M. (Julie M.)\|\|\|/items/9468165c-c674-4c9d-9a3c-e94a64e7f2a8Caminada-de-Toledo, S.R. (Silvia Regina)\|\|\|/items/5a35bb13-2e22-4729-9fbd-b46e6f60f707Petrilli, A.S. (Antonio S.)\|\|\|/items/37244261-c18e-4e91-9767-4cce329cec98Flanagan, A.M. (Adrienne M.)\|\|\|/items/0443ec23-fe6a-49ed-87ae-1ff2e49e39f0Tirabosco, R. (Roberto)\|\|\|/items/dcca7576-36b5-4650-bd3e-e0d1cec1a35fAndrulis, I.L. (Irene L.)\|\|\|/items/d69f2ad8-1f3a-48ea-9d4b-d494c894a037Wunder, J.S. (Jay S.)\|\|\|/items/a8d4ddc7-21fe-455a-8d40-a78285b7a4dfGokgoz, N. (Nalan)\|\|\|/items/d473d928-06b3-4983-b514-3930b03ae61fPatiño-García, A. (Ana)\|\|\|/items/d68c74f1-df22-4e04-9b77-9cf48fd87b46Lecanda, F. (Fernando)\|\|\|/items/3fac5441-504d-4927-979a-5460140b12ecSerra, M. (Massimo)\|\|\|/items/c8910a1b-27ca-4c3b-9269-d0428639586bHattinger, C. (Claudia)\|\|\|/items/8941a946-d617-40bd-a72c-702c43e68519Picci, P. (Piero)\|\|\|/items/de3a871f-f41e-4985-981d-13b86c7998b3Scotlandi, K. (Katia)\|\|\|/items/ed376d03-a408-4ba6-8042-eea14f5b1ee7Thomas, D.M. (David M.)\|\|\|/items/dbed693a-f378-42be-8e16-3f7a1b513041Ballinger, M.L. (Mandy L.)\|\|\|/items/22927a92-fc4b-4b0e-ab5d-e2a0142255beGorlick, R.G. (Richard G.)\|\|\|/items/81f87e34-37fd-40b9-b4e9-bd17cbff954dBarkauskas, D.A. (Donald A.)\|\|\|/items/95137ff6-0a3f-4546-8844-f3461e0b2b20Spector, L. (Logan)\|\|\|/items/26e3e4de-dc41-4f41-848a-11f348546e18Tucker, M. (Margaret)\|\|\|/items/cd38ecc3-c72b-4ddf-b57a-f07f5e772cc8Hicks, B. (Belynda)\|\|\|/items/7c7b8bf7-59a6-43fa-bc23-5ebb6ca20ed4Yeager, M. (Meredith)\|\|\|/items/ba948e8b-ad2a-42a8-a20e-8edbc3a7873bHoover, R.N. (Robert N.)\|\|\|/items/c70b6d66-dd1b-4bb3-9744-fd09272edc93Wacholder, S. (Sholom)\|\|\|/items/cd3a62c1-0ac4-4b6a-8514-19ffb6cdf2b8Chanock, S.J. (Stephen J.)\|\|\|/items/831081e7-45d2-40ad-826a-84127a3c895bSavage, S.A. (Sharon A.)\|\|\|/items/cd3f20bc-c3cd-4bcc-86ff-f94854e8d464Mirabello, L. (Lisa)\|\|\|/items/5874a672-c4aa-4c41-81a9-43de48bab763OsteosarcomaOverall survivalGenome-wide association studyOsteosarcoma-specific survivalSurvival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall survival in 632 patients with osteosarcoma, including 523 patients of European ancestry and 109 from Brazil. We conducted a time-to-event analysis and estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards models, with and without adjustment for metastatic disease.John Wiley & Sons, LtdDadun. Depósito Académico Digital Universidad de Navarra20232023-02-2120182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/65525reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/655252026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients
title	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients
spellingShingle	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients Koster, R. (Roelof)\|\|\|/items/36649332-0f02-4645-a4c7-e0c5021e0786 Osteosarcoma Overall survival Genome-wide association study Osteosarcoma-specific survival
title_short	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients
title_full	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients
title_fullStr	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients
title_full_unstemmed	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients
title_sort	Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients
dc.creator.none.fl_str_mv	Koster, R. (Roelof)\|\|\|/items/36649332-0f02-4645-a4c7-e0c5021e0786 Panagiotou, O.A. (Orestis A.)\|\|\|/items/8d4d5996-23e7-436c-9ea4-3b21ff54ee51 Wheeler, W. (William)\|\|\|/items/83edd778-ee3d-461d-8efd-d5e8298ea183 Karlins, E. (Eric)\|\|\|/items/facb693a-cefc-4d9b-a952-b953e243ee34 Gastier-Foster, J.M. (Julie M.)\|\|\|/items/9468165c-c674-4c9d-9a3c-e94a64e7f2a8 Caminada-de-Toledo, S.R. (Silvia Regina)\|\|\|/items/5a35bb13-2e22-4729-9fbd-b46e6f60f707 Petrilli, A.S. (Antonio S.)\|\|\|/items/37244261-c18e-4e91-9767-4cce329cec98 Flanagan, A.M. (Adrienne M.)\|\|\|/items/0443ec23-fe6a-49ed-87ae-1ff2e49e39f0 Tirabosco, R. (Roberto)\|\|\|/items/dcca7576-36b5-4650-bd3e-e0d1cec1a35f Andrulis, I.L. (Irene L.)\|\|\|/items/d69f2ad8-1f3a-48ea-9d4b-d494c894a037 Wunder, J.S. (Jay S.)\|\|\|/items/a8d4ddc7-21fe-455a-8d40-a78285b7a4df Gokgoz, N. (Nalan)\|\|\|/items/d473d928-06b3-4983-b514-3930b03ae61f Patiño-García, A. (Ana)\|\|\|/items/d68c74f1-df22-4e04-9b77-9cf48fd87b46 Lecanda, F. (Fernando)\|\|\|/items/3fac5441-504d-4927-979a-5460140b12ec Serra, M. (Massimo)\|\|\|/items/c8910a1b-27ca-4c3b-9269-d0428639586b Hattinger, C. (Claudia)\|\|\|/items/8941a946-d617-40bd-a72c-702c43e68519 Picci, P. (Piero)\|\|\|/items/de3a871f-f41e-4985-981d-13b86c7998b3 Scotlandi, K. (Katia)\|\|\|/items/ed376d03-a408-4ba6-8042-eea14f5b1ee7 Thomas, D.M. (David M.)\|\|\|/items/dbed693a-f378-42be-8e16-3f7a1b513041 Ballinger, M.L. (Mandy L.)\|\|\|/items/22927a92-fc4b-4b0e-ab5d-e2a0142255be Gorlick, R.G. (Richard G.)\|\|\|/items/81f87e34-37fd-40b9-b4e9-bd17cbff954d Barkauskas, D.A. (Donald A.)\|\|\|/items/95137ff6-0a3f-4546-8844-f3461e0b2b20 Spector, L. (Logan)\|\|\|/items/26e3e4de-dc41-4f41-848a-11f348546e18 Tucker, M. (Margaret)\|\|\|/items/cd38ecc3-c72b-4ddf-b57a-f07f5e772cc8 Hicks, B. (Belynda)\|\|\|/items/7c7b8bf7-59a6-43fa-bc23-5ebb6ca20ed4 Yeager, M. (Meredith)\|\|\|/items/ba948e8b-ad2a-42a8-a20e-8edbc3a7873b Hoover, R.N. (Robert N.)\|\|\|/items/c70b6d66-dd1b-4bb3-9744-fd09272edc93 Wacholder, S. (Sholom)\|\|\|/items/cd3a62c1-0ac4-4b6a-8514-19ffb6cdf2b8 Chanock, S.J. (Stephen J.)\|\|\|/items/831081e7-45d2-40ad-826a-84127a3c895b Savage, S.A. (Sharon A.)\|\|\|/items/cd3f20bc-c3cd-4bcc-86ff-f94854e8d464 Mirabello, L. (Lisa)\|\|\|/items/5874a672-c4aa-4c41-81a9-43de48bab763
author	Koster, R. (Roelof)\|\|\|/items/36649332-0f02-4645-a4c7-e0c5021e0786
author_facet	Koster, R. (Roelof)\|\|\|/items/36649332-0f02-4645-a4c7-e0c5021e0786 Panagiotou, O.A. (Orestis A.)\|\|\|/items/8d4d5996-23e7-436c-9ea4-3b21ff54ee51 Wheeler, W. (William)\|\|\|/items/83edd778-ee3d-461d-8efd-d5e8298ea183 Karlins, E. (Eric)\|\|\|/items/facb693a-cefc-4d9b-a952-b953e243ee34 Gastier-Foster, J.M. (Julie M.)\|\|\|/items/9468165c-c674-4c9d-9a3c-e94a64e7f2a8 Caminada-de-Toledo, S.R. (Silvia Regina)\|\|\|/items/5a35bb13-2e22-4729-9fbd-b46e6f60f707 Petrilli, A.S. (Antonio S.)\|\|\|/items/37244261-c18e-4e91-9767-4cce329cec98 Flanagan, A.M. (Adrienne M.)\|\|\|/items/0443ec23-fe6a-49ed-87ae-1ff2e49e39f0 Tirabosco, R. (Roberto)\|\|\|/items/dcca7576-36b5-4650-bd3e-e0d1cec1a35f Andrulis, I.L. (Irene L.)\|\|\|/items/d69f2ad8-1f3a-48ea-9d4b-d494c894a037 Wunder, J.S. (Jay S.)\|\|\|/items/a8d4ddc7-21fe-455a-8d40-a78285b7a4df Gokgoz, N. (Nalan)\|\|\|/items/d473d928-06b3-4983-b514-3930b03ae61f Patiño-García, A. (Ana)\|\|\|/items/d68c74f1-df22-4e04-9b77-9cf48fd87b46 Lecanda, F. (Fernando)\|\|\|/items/3fac5441-504d-4927-979a-5460140b12ec Serra, M. (Massimo)\|\|\|/items/c8910a1b-27ca-4c3b-9269-d0428639586b Hattinger, C. (Claudia)\|\|\|/items/8941a946-d617-40bd-a72c-702c43e68519 Picci, P. (Piero)\|\|\|/items/de3a871f-f41e-4985-981d-13b86c7998b3 Scotlandi, K. (Katia)\|\|\|/items/ed376d03-a408-4ba6-8042-eea14f5b1ee7 Thomas, D.M. (David M.)\|\|\|/items/dbed693a-f378-42be-8e16-3f7a1b513041 Ballinger, M.L. (Mandy L.)\|\|\|/items/22927a92-fc4b-4b0e-ab5d-e2a0142255be Gorlick, R.G. (Richard G.)\|\|\|/items/81f87e34-37fd-40b9-b4e9-bd17cbff954d Barkauskas, D.A. (Donald A.)\|\|\|/items/95137ff6-0a3f-4546-8844-f3461e0b2b20 Spector, L. (Logan)\|\|\|/items/26e3e4de-dc41-4f41-848a-11f348546e18 Tucker, M. (Margaret)\|\|\|/items/cd38ecc3-c72b-4ddf-b57a-f07f5e772cc8 Hicks, B. (Belynda)\|\|\|/items/7c7b8bf7-59a6-43fa-bc23-5ebb6ca20ed4 Yeager, M. (Meredith)\|\|\|/items/ba948e8b-ad2a-42a8-a20e-8edbc3a7873b Hoover, R.N. (Robert N.)\|\|\|/items/c70b6d66-dd1b-4bb3-9744-fd09272edc93 Wacholder, S. (Sholom)\|\|\|/items/cd3a62c1-0ac4-4b6a-8514-19ffb6cdf2b8 Chanock, S.J. (Stephen J.)\|\|\|/items/831081e7-45d2-40ad-826a-84127a3c895b Savage, S.A. (Sharon A.)\|\|\|/items/cd3f20bc-c3cd-4bcc-86ff-f94854e8d464 Mirabello, L. (Lisa)\|\|\|/items/5874a672-c4aa-4c41-81a9-43de48bab763
author_role	author
author2	Panagiotou, O.A. (Orestis A.)\|\|\|/items/8d4d5996-23e7-436c-9ea4-3b21ff54ee51 Wheeler, W. (William)\|\|\|/items/83edd778-ee3d-461d-8efd-d5e8298ea183 Karlins, E. (Eric)\|\|\|/items/facb693a-cefc-4d9b-a952-b953e243ee34 Gastier-Foster, J.M. (Julie M.)\|\|\|/items/9468165c-c674-4c9d-9a3c-e94a64e7f2a8 Caminada-de-Toledo, S.R. (Silvia Regina)\|\|\|/items/5a35bb13-2e22-4729-9fbd-b46e6f60f707 Petrilli, A.S. (Antonio S.)\|\|\|/items/37244261-c18e-4e91-9767-4cce329cec98 Flanagan, A.M. (Adrienne M.)\|\|\|/items/0443ec23-fe6a-49ed-87ae-1ff2e49e39f0 Tirabosco, R. (Roberto)\|\|\|/items/dcca7576-36b5-4650-bd3e-e0d1cec1a35f Andrulis, I.L. (Irene L.)\|\|\|/items/d69f2ad8-1f3a-48ea-9d4b-d494c894a037 Wunder, J.S. (Jay S.)\|\|\|/items/a8d4ddc7-21fe-455a-8d40-a78285b7a4df Gokgoz, N. (Nalan)\|\|\|/items/d473d928-06b3-4983-b514-3930b03ae61f Patiño-García, A. (Ana)\|\|\|/items/d68c74f1-df22-4e04-9b77-9cf48fd87b46 Lecanda, F. (Fernando)\|\|\|/items/3fac5441-504d-4927-979a-5460140b12ec Serra, M. (Massimo)\|\|\|/items/c8910a1b-27ca-4c3b-9269-d0428639586b Hattinger, C. (Claudia)\|\|\|/items/8941a946-d617-40bd-a72c-702c43e68519 Picci, P. (Piero)\|\|\|/items/de3a871f-f41e-4985-981d-13b86c7998b3 Scotlandi, K. (Katia)\|\|\|/items/ed376d03-a408-4ba6-8042-eea14f5b1ee7 Thomas, D.M. (David M.)\|\|\|/items/dbed693a-f378-42be-8e16-3f7a1b513041 Ballinger, M.L. (Mandy L.)\|\|\|/items/22927a92-fc4b-4b0e-ab5d-e2a0142255be Gorlick, R.G. (Richard G.)\|\|\|/items/81f87e34-37fd-40b9-b4e9-bd17cbff954d Barkauskas, D.A. (Donald A.)\|\|\|/items/95137ff6-0a3f-4546-8844-f3461e0b2b20 Spector, L. (Logan)\|\|\|/items/26e3e4de-dc41-4f41-848a-11f348546e18 Tucker, M. (Margaret)\|\|\|/items/cd38ecc3-c72b-4ddf-b57a-f07f5e772cc8 Hicks, B. (Belynda)\|\|\|/items/7c7b8bf7-59a6-43fa-bc23-5ebb6ca20ed4 Yeager, M. (Meredith)\|\|\|/items/ba948e8b-ad2a-42a8-a20e-8edbc3a7873b Hoover, R.N. (Robert N.)\|\|\|/items/c70b6d66-dd1b-4bb3-9744-fd09272edc93 Wacholder, S. (Sholom)\|\|\|/items/cd3a62c1-0ac4-4b6a-8514-19ffb6cdf2b8 Chanock, S.J. (Stephen J.)\|\|\|/items/831081e7-45d2-40ad-826a-84127a3c895b Savage, S.A. (Sharon A.)\|\|\|/items/cd3f20bc-c3cd-4bcc-86ff-f94854e8d464 Mirabello, L. (Lisa)\|\|\|/items/5874a672-c4aa-4c41-81a9-43de48bab763
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Osteosarcoma Overall survival Genome-wide association study Osteosarcoma-specific survival
topic	Osteosarcoma Overall survival Genome-wide association study Osteosarcoma-specific survival
description	Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall survival in 632 patients with osteosarcoma, including 523 patients of European ancestry and 109 from Brazil. We conducted a time-to-event analysis and estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards models, with and without adjustment for metastatic disease.
publishDate	2018
dc.date.none.fl_str_mv	2018 2018-01-01 2018 2018-01-01 2023 2023-02-21
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/65525
url	https://hdl.handle.net/10171/65525
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	John Wiley & Sons, Ltd
publisher.none.fl_str_mv	John Wiley & Sons, Ltd
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,300719

Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

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