Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.

BACKGROUND: Despite the importance of gestation period for human health, studies addressing the impact of maternal microbiota on its progression and its modulation by maternal lifestyle are scarce. Although most of the evidence in the field comes from observational studies, we recently described how...

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Autores: Selma-Royo M, Crispi F, Castro-Barquero S, Casas I, Larroya M, Genero M, Paules C, Benitez L, Youssef L, Pascal R, Encabo N, Nakaki A, Martín-Asuero A, Oller-Guzmán MT, Arranz A, Vieta E, Casas R, Estruch R, Gratacos E, Collado MC, Crovetto F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p29015
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29015
Access Level:acceso abierto
Palabra clave:Mediterranean diet
Stress reduction
microbiota
pregnancy
randomized clinical trial
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spelling Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.Selma-Royo MCrispi FCastro-Barquero SCasas ILarroya MGenero MPaules CBenitez LYoussef LPascal REncabo NNakaki AMartín-Asuero AOller-Guzmán MTArranz AVieta ECasas REstruch RGratacos ECollado MCCrovetto FMediterranean dietStress reductionmicrobiotapregnancyrandomized clinical trialBACKGROUND: Despite the importance of gestation period for human health, studies addressing the impact of maternal microbiota on its progression and its modulation by maternal lifestyle are scarce. Although most of the evidence in the field comes from observational studies, we recently described how some lifestyle interventions during pregnancy reduced the small-for-gestational-age (SGA) incidence. We hypothesized the pregnant individual's microbiome modulation as potential mechanism by which lifestyle interventions could impact gestation progression. OBJECTIVES: The objectives of this study was to investigate the effect of pregnancy lifestyle interventions, based on a Mediterranean dietary pattern (MD) or Stress Reduction program (SR) that proved to be beneficial in reducing the SGA incidence, on the pregnant individuals' gut and vaginal microbiota as exploratory outcomes. METHODS: In a random subsample (n = 351) from a trial including pregnancies randomly allocated into an MD intervention, an SR program, or non-intervention, maternal fecal/vaginal samples were collected at the end of the interventions, and in a subset (n = 85) also at recruitment. Microbiota was profiled by 16S rRNA gene sequencing. Multivariate models evaluated the associations of microbiota with the interventions. RESULTS: Mothers included in the study presented a similar gut microbiota profile before the intervention; pregnancy MD intervention influenced the overall structure of gut microbiota, (R2 = 0.008, F = 1.885, P = 0.002), which resulted in enrichment in Firmicutes phylum (Coeff = 0.06, 95% confidence interval [CI]: 0.002, 0.118), related to the increment in health-associated taxa (Lachnospiraceae/Ruminococcaceae families) and other SCFA producers; and diminishment in Campylobacter genus (Coeff = -0.91, 95% CI: -1.361, -0.459). The link of the SR program with gut microbiota was more limited; however, some key components from these families were also affected. Microbial diversity of gut microbiota decreased as pregnancy progressed, with this effect more observable in the mothers that followed the interventions. The interventions have a negligible association with the vaginal microbiota. CONCLUSIONS: Pregnancy lifestyle interventions influence maternal gut microbiota. The trial was registered at clinicaltrials.gov Identifier as NCT03166332. CLINICAL TRIAL INFORMATION: Date of Institutional Review Board approval and registration: 16 December 2016; 19 April 2017; Date of initial participant enrollment and date of first outcome (i.e., delivery of the pregnant individual enrolled): 1 February 2017; 10 May 2017.ELSEVIER SCIENCE INC2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29015AMERICAN JOURNAL OF CLINICAL NUTRITIONISSN: 00029165ISSNe: 19383207reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p290152026-05-27T12:37:41Z
dc.title.none.fl_str_mv Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.
title Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.
spellingShingle Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.
Selma-Royo M
Mediterranean diet
Stress reduction
microbiota
pregnancy
randomized clinical trial
title_short Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.
title_full Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.
title_fullStr Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.
title_full_unstemmed Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.
title_sort Effects of Mediterranean diet or Mindfulness-Based Stress Reduction during pregnancy on maternal gut and vaginal microbiota: a subanalysis of the Improving Mothers for a better PrenAtal Care Trial BarCeloNa (IMPACT BCN) trial.
dc.creator.none.fl_str_mv Selma-Royo M
Crispi F
Castro-Barquero S
Casas I
Larroya M
Genero M
Paules C
Benitez L
Youssef L
Pascal R
Encabo N
Nakaki A
Martín-Asuero A
Oller-Guzmán MT
Arranz A
Vieta E
Casas R
Estruch R
Gratacos E
Collado MC
Crovetto F
author Selma-Royo M
author_facet Selma-Royo M
Crispi F
Castro-Barquero S
Casas I
Larroya M
Genero M
Paules C
Benitez L
Youssef L
Pascal R
Encabo N
Nakaki A
Martín-Asuero A
Oller-Guzmán MT
Arranz A
Vieta E
Casas R
Estruch R
Gratacos E
Collado MC
Crovetto F
author_role author
author2 Crispi F
Castro-Barquero S
Casas I
Larroya M
Genero M
Paules C
Benitez L
Youssef L
Pascal R
Encabo N
Nakaki A
Martín-Asuero A
Oller-Guzmán MT
Arranz A
Vieta E
Casas R
Estruch R
Gratacos E
Collado MC
Crovetto F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mediterranean diet
Stress reduction
microbiota
pregnancy
randomized clinical trial
topic Mediterranean diet
Stress reduction
microbiota
pregnancy
randomized clinical trial
description BACKGROUND: Despite the importance of gestation period for human health, studies addressing the impact of maternal microbiota on its progression and its modulation by maternal lifestyle are scarce. Although most of the evidence in the field comes from observational studies, we recently described how some lifestyle interventions during pregnancy reduced the small-for-gestational-age (SGA) incidence. We hypothesized the pregnant individual's microbiome modulation as potential mechanism by which lifestyle interventions could impact gestation progression. OBJECTIVES: The objectives of this study was to investigate the effect of pregnancy lifestyle interventions, based on a Mediterranean dietary pattern (MD) or Stress Reduction program (SR) that proved to be beneficial in reducing the SGA incidence, on the pregnant individuals' gut and vaginal microbiota as exploratory outcomes. METHODS: In a random subsample (n = 351) from a trial including pregnancies randomly allocated into an MD intervention, an SR program, or non-intervention, maternal fecal/vaginal samples were collected at the end of the interventions, and in a subset (n = 85) also at recruitment. Microbiota was profiled by 16S rRNA gene sequencing. Multivariate models evaluated the associations of microbiota with the interventions. RESULTS: Mothers included in the study presented a similar gut microbiota profile before the intervention; pregnancy MD intervention influenced the overall structure of gut microbiota, (R2 = 0.008, F = 1.885, P = 0.002), which resulted in enrichment in Firmicutes phylum (Coeff = 0.06, 95% confidence interval [CI]: 0.002, 0.118), related to the increment in health-associated taxa (Lachnospiraceae/Ruminococcaceae families) and other SCFA producers; and diminishment in Campylobacter genus (Coeff = -0.91, 95% CI: -1.361, -0.459). The link of the SR program with gut microbiota was more limited; however, some key components from these families were also affected. Microbial diversity of gut microbiota decreased as pregnancy progressed, with this effect more observable in the mothers that followed the interventions. The interventions have a negligible association with the vaginal microbiota. CONCLUSIONS: Pregnancy lifestyle interventions influence maternal gut microbiota. The trial was registered at clinicaltrials.gov Identifier as NCT03166332. CLINICAL TRIAL INFORMATION: Date of Institutional Review Board approval and registration: 16 December 2016; 19 April 2017; Date of initial participant enrollment and date of first outcome (i.e., delivery of the pregnant individual enrolled): 1 February 2017; 10 May 2017.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29015
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29015
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv AMERICAN JOURNAL OF CLINICAL NUTRITION
ISSN: 00029165
ISSNe: 19383207
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
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collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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