Competing risks to breast cancer mortality in Catalonia

Background: Breast cancer mortality has experienced important changes over the last century. Breast cancer occurs in the presence of other competing risks which can influence breast cancer incidence and mortality trends. The aim of the present work is: 1) to assess the impact of breast cancer deaths...

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Autores: Vilaprinyo, Ester, Gispert, Rosa, Martínez Alonso, Montserrat, Carles Lavila, Misericòrdia, Pla, Roger, Espinàs Piñol, Josep Alfons, Rué, Montserrat
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126629
Acesso em linha:https://hdl.handle.net/2445/126629
Access Level:acceso abierto
Palavra-chave:Càncer de mama
Mortalitat
Breast cancer
Mortality
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spelling Competing risks to breast cancer mortality in CataloniaVilaprinyo, EsterGispert, RosaMartínez Alonso, MontserratCarles Lavila, MisericòrdiaPla, RogerEspinàs Piñol, Josep AlfonsRué, MontserratCàncer de mamaMortalitatBreast cancerMortalityBackground: Breast cancer mortality has experienced important changes over the last century. Breast cancer occurs in the presence of other competing risks which can influence breast cancer incidence and mortality trends. The aim of the present work is: 1) to assess the impact of breast cancer deaths among mortality from all causes in Catalonia (Spain), by age and birth cohort and 2) to estimate the risk of death from other causes than breast cancer, one of the inputs needed to model breast cancer mortality reduction due to screening or therapeutic interventions. Methods: The multi-decrement life table methodology was used. First, all-cause mortality probabilities were obtained by age and cohort. Then mortality probability for breast cancer was subtracted from the all-cause mortality probabilities to obtain cohort life tables for causes other than breast cancer. These life tables, on one hand, provide an estimate of the risk of dying from competing risks, and on the other hand, permit to assess the impact of breast cancer deaths on all-cause mortality using the ratio of the probability of death for causes other than breast cancer by the all-cause probability of death. Results: There was an increasing impact of breast cancer on mortality in the first part of the 20(th) century, with a peak for cohorts born in 1945-54 in the 40-49 age groups (for which approximately 24% of mortality was due to breast cancer). Even though for cohorts born after 1955 there was only information for women under 50, it is also important to note that the impact of breast cancer on all-cause mortality decreased for those cohorts. Conclusion: We have quantified the effect of removing breast cancer mortality in different age groups and birth cohorts. Our results are consistent with US findings. We also have obtained an estimate of the risk of dying from competing-causes mortality, which will be used in the assessment of the effect of mammography screening on breast cancer mortality in Catalonia.BioMed Central2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126629Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/1471-2407-8-331BMC Cancer, 2008, vol. 8, num. 331https://doi.org/10.1186/1471-2407-8-331cc by (c) Vilaprinyo et al., 2008http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1266292026-05-27T06:46:51Z
dc.title.none.fl_str_mv Competing risks to breast cancer mortality in Catalonia
title Competing risks to breast cancer mortality in Catalonia
spellingShingle Competing risks to breast cancer mortality in Catalonia
Vilaprinyo, Ester
Càncer de mama
Mortalitat
Breast cancer
Mortality
title_short Competing risks to breast cancer mortality in Catalonia
title_full Competing risks to breast cancer mortality in Catalonia
title_fullStr Competing risks to breast cancer mortality in Catalonia
title_full_unstemmed Competing risks to breast cancer mortality in Catalonia
title_sort Competing risks to breast cancer mortality in Catalonia
dc.creator.none.fl_str_mv Vilaprinyo, Ester
Gispert, Rosa
Martínez Alonso, Montserrat
Carles Lavila, Misericòrdia
Pla, Roger
Espinàs Piñol, Josep Alfons
Rué, Montserrat
author Vilaprinyo, Ester
author_facet Vilaprinyo, Ester
Gispert, Rosa
Martínez Alonso, Montserrat
Carles Lavila, Misericòrdia
Pla, Roger
Espinàs Piñol, Josep Alfons
Rué, Montserrat
author_role author
author2 Gispert, Rosa
Martínez Alonso, Montserrat
Carles Lavila, Misericòrdia
Pla, Roger
Espinàs Piñol, Josep Alfons
Rué, Montserrat
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de mama
Mortalitat
Breast cancer
Mortality
topic Càncer de mama
Mortalitat
Breast cancer
Mortality
description Background: Breast cancer mortality has experienced important changes over the last century. Breast cancer occurs in the presence of other competing risks which can influence breast cancer incidence and mortality trends. The aim of the present work is: 1) to assess the impact of breast cancer deaths among mortality from all causes in Catalonia (Spain), by age and birth cohort and 2) to estimate the risk of death from other causes than breast cancer, one of the inputs needed to model breast cancer mortality reduction due to screening or therapeutic interventions. Methods: The multi-decrement life table methodology was used. First, all-cause mortality probabilities were obtained by age and cohort. Then mortality probability for breast cancer was subtracted from the all-cause mortality probabilities to obtain cohort life tables for causes other than breast cancer. These life tables, on one hand, provide an estimate of the risk of dying from competing risks, and on the other hand, permit to assess the impact of breast cancer deaths on all-cause mortality using the ratio of the probability of death for causes other than breast cancer by the all-cause probability of death. Results: There was an increasing impact of breast cancer on mortality in the first part of the 20(th) century, with a peak for cohorts born in 1945-54 in the 40-49 age groups (for which approximately 24% of mortality was due to breast cancer). Even though for cohorts born after 1955 there was only information for women under 50, it is also important to note that the impact of breast cancer on all-cause mortality decreased for those cohorts. Conclusion: We have quantified the effect of removing breast cancer mortality in different age groups and birth cohorts. Our results are consistent with US findings. We also have obtained an estimate of the risk of dying from competing-causes mortality, which will be used in the assessment of the effect of mammography screening on breast cancer mortality in Catalonia.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126629
url https://hdl.handle.net/2445/126629
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/1471-2407-8-331
BMC Cancer, 2008, vol. 8, num. 331
https://doi.org/10.1186/1471-2407-8-331
dc.rights.none.fl_str_mv cc by (c) Vilaprinyo et al., 2008
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Vilaprinyo et al., 2008
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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