Regulation of anti-phage defense mechanisms by using cinnamaldehyde as a quorum sensing inhibitor
Multidrug-resistant bacteria and the shortage of new antibiotics constitute a serious health problem. This problem has led to increased interest in the use of bacteriophages, which have great potential as antimicrobial agents but also carry the risk of inducing resistance. The objective of the prese...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/386657 |
| Acceso en línea: | http://hdl.handle.net/10261/386657 https://api.elsevier.com/content/abstract/scopus_id/85197776640 |
| Access Level: | acceso abierto |
| Palabra clave: | Klebsiella pneumoniae Anti-phage defense mechanisms Cinnamaldehyde Phage resistance Proteome Quorum sensing |
| Sumario: | Multidrug-resistant bacteria and the shortage of new antibiotics constitute a serious health problem. This problem has led to increased interest in the use of bacteriophages, which have great potential as antimicrobial agents but also carry the risk of inducing resistance. The objective of the present study was to minimize the development of phage resistance in Klebsiella pneumoniae strains by inhibiting quorum sensing (QS) and thus demonstrate the role of QS in regulating defense mechanisms. |
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