Divergent Strategy in Marine Tetracyclic Meroterpenoids Synthesis

The divergent total synthesis strategy can be successfully applied to the preparation of families of natural products using a common late-stage pluripotent intermediate. This approach is a powerful tool in organic synthesis as it offers opportunities for the efficient preparation of structurally rel...

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Bibliographic Details
Authors: Rosales Martínez, Antonio, Rodríguez-García, Ignacio, López-Martínez, Josefa L.
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/114793
Online Access:https://hdl.handle.net/11441/114793
https://doi.org/10.3390/md19050273
Access Level:Open access
Keyword:Divergent total synthesis
Marine natural products
Tetracyclic meroterpenoids
Aureol
Description
Summary:The divergent total synthesis strategy can be successfully applied to the preparation of families of natural products using a common late-stage pluripotent intermediate. This approach is a powerful tool in organic synthesis as it offers opportunities for the efficient preparation of structurally related compounds. This article reviews the synthesis of the marine natural product aureol, as well as its use as a common intermediate in the divergent synthesis of other marine natural and non-natural tetracyclic meroterpenoids.