Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions

Pleural effusions are common in patients with cancer and cause a significant morbidity. The optimal treatment for the control of pleural effusions is not defined. In patients with drug-sensitive tumors (e.g. breast cancer, lymphomas, small-cell lung cancer) systemic chemotherapy is the treatment of...

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Detalles Bibliográficos
Autores: Morales González, Manuel José, Expósito, María del Carmen
Tipo de recurso: artículo
Fecha de publicación:1995
País:España
Institución:Universidad de La Laguna (ULL)
Repositorio:RIULL. Repositorio Institucional de la Universidad de La Laguna
OAI Identifier:oai:riull.ull.es:915/40030
Acceso en línea:http://riull.ull.es/xmlui/handle/915/40030
Access Level:acceso abierto
Palabra clave:Intrapleural mitoxantrone
pleural effusions
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spelling Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusionsMorales González, Manuel JoséExpósito, María del CarmenIntrapleural mitoxantronepleural effusionsPleural effusions are common in patients with cancer and cause a significant morbidity. The optimal treatment for the control of pleural effusions is not defined. In patients with drug-sensitive tumors (e.g. breast cancer, lymphomas, small-cell lung cancer) systemic chemotherapy is the treatment of choice. For patients with other solid tumors and in recurrences despite systemic chemotherapy, the optimal treatment consists of thoracostomy-tube drainage with the instillation of a sclerosing agent [3]. Several agents are used to achieve pleuorodesis: tetracycline, bleomycin, quinacrine, nitrogen mustard, doxorubicin, mitoxantrone and talc [7]. Mitoxantrone shows a steep dose/effect relationship for different human tumor cell lines in vitro, and is a drug well tolerated locally [2]. Whilst the usual dose of mitoxantrone for intrapleural therapy is 30 mg [6], we increased the dose to 40 mg.Medicina Interna, Dermatología y Psiquiatría202420241995info:eu-repo/semantics/articleapplication/pdfhttp://riull.ull.es/xmlui/handle/915/40030reponame:RIULL. Repositorio Institucional de la Universidad de La Lagunainstname:Universidad de La Laguna (ULL)InglésSupportive Care Cancer, 1995, 3Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ESoai:riull.ull.es:915/400302026-06-22T13:13:57Z
dc.title.none.fl_str_mv Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions
title Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions
spellingShingle Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions
Morales González, Manuel José
Intrapleural mitoxantrone
pleural effusions
title_short Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions
title_full Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions
title_fullStr Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions
title_full_unstemmed Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions
title_sort Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions
dc.creator.none.fl_str_mv Morales González, Manuel José
Expósito, María del Carmen
author Morales González, Manuel José
author_facet Morales González, Manuel José
Expósito, María del Carmen
author_role author
author2 Expósito, María del Carmen
author2_role author
dc.contributor.none.fl_str_mv Medicina Interna, Dermatología y Psiquiatría
dc.subject.none.fl_str_mv Intrapleural mitoxantrone
pleural effusions
topic Intrapleural mitoxantrone
pleural effusions
description Pleural effusions are common in patients with cancer and cause a significant morbidity. The optimal treatment for the control of pleural effusions is not defined. In patients with drug-sensitive tumors (e.g. breast cancer, lymphomas, small-cell lung cancer) systemic chemotherapy is the treatment of choice. For patients with other solid tumors and in recurrences despite systemic chemotherapy, the optimal treatment consists of thoracostomy-tube drainage with the instillation of a sclerosing agent [3]. Several agents are used to achieve pleuorodesis: tetracycline, bleomycin, quinacrine, nitrogen mustard, doxorubicin, mitoxantrone and talc [7]. Mitoxantrone shows a steep dose/effect relationship for different human tumor cell lines in vitro, and is a drug well tolerated locally [2]. Whilst the usual dose of mitoxantrone for intrapleural therapy is 30 mg [6], we increased the dose to 40 mg.
publishDate 1995
dc.date.none.fl_str_mv 1995
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://riull.ull.es/xmlui/handle/915/40030
url http://riull.ull.es/xmlui/handle/915/40030
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Supportive Care Cancer, 1995, 3
dc.rights.none.fl_str_mv Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
rights_invalid_str_mv Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIULL. Repositorio Institucional de la Universidad de La Laguna
instname:Universidad de La Laguna (ULL)
instname_str Universidad de La Laguna (ULL)
reponame_str RIULL. Repositorio Institucional de la Universidad de La Laguna
collection RIULL. Repositorio Institucional de la Universidad de La Laguna
repository.name.fl_str_mv
repository.mail.fl_str_mv
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