Elastin and collagen fibres in cutaneous wound healing

Skin forms the outer barrier of the body. Upon injury, successful wound healing in normal skin restores tissue damage and counteracts the loss of extracellular matrix (ECM) proteins and cells. Collagens and elastin are the most abundant structural proteins of the ECM. In homeostasis, collagen type I...

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Autores: Gardeazabal, L. (Leire)|||/items/9474e995-f2b4-4b8f-9c32-b3ccfeb07dfd, Izeta, A. (Ander)|||/items/d3c631a7-8a76-4d8f-9088-76dc5f16db47
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/70000
Acceso en línea:https://hdl.handle.net/10171/70000
Access Level:acceso abierto
Palabra clave:Collagen
Elastic fibres
Extracellular matrix (ECM)
Skin
Wound healing
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spelling Elastin and collagen fibres in cutaneous wound healingGardeazabal, L. (Leire)|||/items/9474e995-f2b4-4b8f-9c32-b3ccfeb07dfdIzeta, A. (Ander)|||/items/d3c631a7-8a76-4d8f-9088-76dc5f16db47CollagenElastic fibresExtracellular matrix (ECM)SkinWound healingSkin forms the outer barrier of the body. Upon injury, successful wound healing in normal skin restores tissue damage and counteracts the loss of extracellular matrix (ECM) proteins and cells. Collagens and elastin are the most abundant structural proteins of the ECM. In homeostasis, collagen type I is the prevalent form, but it is replaced by type III collagen upon wounding, and only later remodelled. In turn, unsuccessful healing results in scars, which tend to be inflexible and inelastic as compared to normal elastic dermis. Scar inelasticity may be due to the absence of mature elastin fibre formation and cross-linking. In this review, the available information on the process of formation of new collagen and elastic fibres during wound healing is analysed. The distinct roles of elastin and collagen proteins during healing are revisited and future research directions proposed which may help improve clinical management of open wounds and scars.John Wiley & SonsDadun. Depósito Académico Digital Universidad de Navarra20242024-09-2720242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/70000reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/700002026-06-21T12:47:57Z
dc.title.none.fl_str_mv Elastin and collagen fibres in cutaneous wound healing
title Elastin and collagen fibres in cutaneous wound healing
spellingShingle Elastin and collagen fibres in cutaneous wound healing
Gardeazabal, L. (Leire)|||/items/9474e995-f2b4-4b8f-9c32-b3ccfeb07dfd
Collagen
Elastic fibres
Extracellular matrix (ECM)
Skin
Wound healing
title_short Elastin and collagen fibres in cutaneous wound healing
title_full Elastin and collagen fibres in cutaneous wound healing
title_fullStr Elastin and collagen fibres in cutaneous wound healing
title_full_unstemmed Elastin and collagen fibres in cutaneous wound healing
title_sort Elastin and collagen fibres in cutaneous wound healing
dc.creator.none.fl_str_mv Gardeazabal, L. (Leire)|||/items/9474e995-f2b4-4b8f-9c32-b3ccfeb07dfd
Izeta, A. (Ander)|||/items/d3c631a7-8a76-4d8f-9088-76dc5f16db47
author Gardeazabal, L. (Leire)|||/items/9474e995-f2b4-4b8f-9c32-b3ccfeb07dfd
author_facet Gardeazabal, L. (Leire)|||/items/9474e995-f2b4-4b8f-9c32-b3ccfeb07dfd
Izeta, A. (Ander)|||/items/d3c631a7-8a76-4d8f-9088-76dc5f16db47
author_role author
author2 Izeta, A. (Ander)|||/items/d3c631a7-8a76-4d8f-9088-76dc5f16db47
author2_role author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Collagen
Elastic fibres
Extracellular matrix (ECM)
Skin
Wound healing
topic Collagen
Elastic fibres
Extracellular matrix (ECM)
Skin
Wound healing
description Skin forms the outer barrier of the body. Upon injury, successful wound healing in normal skin restores tissue damage and counteracts the loss of extracellular matrix (ECM) proteins and cells. Collagens and elastin are the most abundant structural proteins of the ECM. In homeostasis, collagen type I is the prevalent form, but it is replaced by type III collagen upon wounding, and only later remodelled. In turn, unsuccessful healing results in scars, which tend to be inflexible and inelastic as compared to normal elastic dermis. Scar inelasticity may be due to the absence of mature elastin fibre formation and cross-linking. In this review, the available information on the process of formation of new collagen and elastic fibres during wound healing is analysed. The distinct roles of elastin and collagen proteins during healing are revisited and future research directions proposed which may help improve clinical management of open wounds and scars.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-09-27
2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/70000
url https://hdl.handle.net/10171/70000
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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