Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies

Study design: Systematic review and meta-analysis of observational studies. Objective: This systematic review and meta-analysis aimed to assess the possible relationship between atypical laterality curves and neural axis abnormalities (NAAs). Summary: Idiopathic scoliosis (IS) is a three-dimensional...

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Autores: Cortés-Pérez, Irene, Gallego-Síles, Juan Ramón, Obrero, Esteban, Ibáñez-Vera, Alfonso Javier, Peinado-Rubia, Ana Belén, Lomas-Vega, Rafael
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2025
País:España
Institución:Universidad de Jaén
Repositorio:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
OAI Identifier:oai:ruja.ujaen.es:10953/6293
Acceso en línea:https://journals.lww.com/spinejournal/fulltext/2025/11150/prevalence_of_neural_axis_abnormalities_in_typical.11.aspx
https://hdl.handle.net/10953/6293
Access Level:acceso abierto
Palabra clave:Atypical laterality curve
Idiopathic scoliosis
Neural axis abnormalities
Scoliosis
Typical laterality curve
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spelling Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational StudiesCortés-Pérez, IreneGallego-Síles, Juan RamónObrero, EstebanIbáñez-Vera, Alfonso JavierPeinado-Rubia, Ana BelénLomas-Vega, RafaelAtypical laterality curveIdiopathic scoliosisNeural axis abnormalitiesScoliosisTypical laterality curve615.8Study design: Systematic review and meta-analysis of observational studies. Objective: This systematic review and meta-analysis aimed to assess the possible relationship between atypical laterality curves and neural axis abnormalities (NAAs). Summary: Idiopathic scoliosis (IS) is a three-dimensional spinal deformity of unknown origin. Some studies have shown a high prevalence of (NAAs) in patients with IS, with possible differences in the prevalence of NAAs between curves with typical (right thoracic/left lumbar) or atypical laterality (the rest). Methods: This review protocol was previously registered in PROSPERO (CRD42024544809). A systematic search of the PubMed, Scopus, Web of Science, CINAHL and Scopus databases was performed through September 30, 2024. Results: A total of 24 articles published between 1992 and 2021 involving 5379 subjects were included in the analysis. Twenty-four studies reported a prevalence of NAAs among patients with atypical laterality curves of 19.4% (95% CI: 15.6-23.8) and 12.1% (95% CI: 0.1-0.16) among those with typical laterality curves. Eleven studies estimated the prevalence of syringomyelia in patients with atypical laterality at 12.4% (95% CI: 8-18.7) and that in patients with typical laterality at 6.1% (95% CI: 3.8-9.5). Eleven studies reported a prevalence of Arnold-Chiari syndrome in patients with atypical laterality of 12% (95% CI: 6.9-20.1) and 7.7% (95% CI: 3.7-15.4) in those with typical laterality curves. Five studies reported a prevalence of tethered cord at 3.1% (95% CI: 1.3-7.2-) in patients with atypical laterality curves and a 2.1% (95% CI: 0.5-8.8-) prevalence among those with typical laterality. Conclusion: This study revealed that the prevalence of associated NAAs is greater among IS patients with atypical laterality curves, especially in patients with left dorsal curves and/or right lumbar curves. Syringomyelia is the most significant associated anomaly.Wolters Kluwer202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://journals.lww.com/spinejournal/fulltext/2025/11150/prevalence_of_neural_axis_abnormalities_in_typical.11.aspxhttps://hdl.handle.net/10953/6293reponame:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaéninstname:Universidad de JaénInglésSpineCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccessoai:ruja.ujaen.es:10953/62932026-06-24T12:41:07Z
dc.title.none.fl_str_mv Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies
title Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies
spellingShingle Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies
Cortés-Pérez, Irene
Atypical laterality curve
Idiopathic scoliosis
Neural axis abnormalities
Scoliosis
Typical laterality curve
615.8
title_short Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies
title_full Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies
title_fullStr Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies
title_full_unstemmed Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies
title_sort Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies
dc.creator.none.fl_str_mv Cortés-Pérez, Irene
Gallego-Síles, Juan Ramón
Obrero, Esteban
Ibáñez-Vera, Alfonso Javier
Peinado-Rubia, Ana Belén
Lomas-Vega, Rafael
author Cortés-Pérez, Irene
author_facet Cortés-Pérez, Irene
Gallego-Síles, Juan Ramón
Obrero, Esteban
Ibáñez-Vera, Alfonso Javier
Peinado-Rubia, Ana Belén
Lomas-Vega, Rafael
author_role author
author2 Gallego-Síles, Juan Ramón
Obrero, Esteban
Ibáñez-Vera, Alfonso Javier
Peinado-Rubia, Ana Belén
Lomas-Vega, Rafael
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Atypical laterality curve
Idiopathic scoliosis
Neural axis abnormalities
Scoliosis
Typical laterality curve
615.8
topic Atypical laterality curve
Idiopathic scoliosis
Neural axis abnormalities
Scoliosis
Typical laterality curve
615.8
description Study design: Systematic review and meta-analysis of observational studies. Objective: This systematic review and meta-analysis aimed to assess the possible relationship between atypical laterality curves and neural axis abnormalities (NAAs). Summary: Idiopathic scoliosis (IS) is a three-dimensional spinal deformity of unknown origin. Some studies have shown a high prevalence of (NAAs) in patients with IS, with possible differences in the prevalence of NAAs between curves with typical (right thoracic/left lumbar) or atypical laterality (the rest). Methods: This review protocol was previously registered in PROSPERO (CRD42024544809). A systematic search of the PubMed, Scopus, Web of Science, CINAHL and Scopus databases was performed through September 30, 2024. Results: A total of 24 articles published between 1992 and 2021 involving 5379 subjects were included in the analysis. Twenty-four studies reported a prevalence of NAAs among patients with atypical laterality curves of 19.4% (95% CI: 15.6-23.8) and 12.1% (95% CI: 0.1-0.16) among those with typical laterality curves. Eleven studies estimated the prevalence of syringomyelia in patients with atypical laterality at 12.4% (95% CI: 8-18.7) and that in patients with typical laterality at 6.1% (95% CI: 3.8-9.5). Eleven studies reported a prevalence of Arnold-Chiari syndrome in patients with atypical laterality of 12% (95% CI: 6.9-20.1) and 7.7% (95% CI: 3.7-15.4) in those with typical laterality curves. Five studies reported a prevalence of tethered cord at 3.1% (95% CI: 1.3-7.2-) in patients with atypical laterality curves and a 2.1% (95% CI: 0.5-8.8-) prevalence among those with typical laterality. Conclusion: This study revealed that the prevalence of associated NAAs is greater among IS patients with atypical laterality curves, especially in patients with left dorsal curves and/or right lumbar curves. Syringomyelia is the most significant associated anomaly.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://journals.lww.com/spinejournal/fulltext/2025/11150/prevalence_of_neural_axis_abnormalities_in_typical.11.aspx
https://hdl.handle.net/10953/6293
url https://journals.lww.com/spinejournal/fulltext/2025/11150/prevalence_of_neural_axis_abnormalities_in_typical.11.aspx
https://hdl.handle.net/10953/6293
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Spine
dc.rights.none.fl_str_mv CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
instname:Universidad de Jaén
instname_str Universidad de Jaén
reponame_str RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
collection RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
repository.name.fl_str_mv
repository.mail.fl_str_mv
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