Differential progression of regional hippocampal atrophy in aging and Parkinson's disease

Hippocampal subfields have different vulnerability to the degenerative processes related to aging, amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the temporal evolution in Parkinson's disease (PD) is unknown. The purposes of the current work are to describe regi...

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Autores: Uribe, Carme, Segura i Fàbregas, Bàrbara, Baggio, Hugo César, Campabadal Delgado, Anna, Abós, Alexandra, Compta, Yaroslau, Martí Domènech, Ma. Josep, Valldeoriola Serra, Francesc, Bargalló Alabart, Núria, Junqué i Plaja, Carme, 1955-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/140428
Acceso en línea:https://hdl.handle.net/2445/140428
Access Level:acceso abierto
Palabra clave:Malaltia de Parkinson
Envelliment
Neurologia
Parkinson's disease
Aging
Neurology
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spelling Differential progression of regional hippocampal atrophy in aging and Parkinson's diseaseUribe, CarmeSegura i Fàbregas, BàrbaraBaggio, Hugo CésarCampabadal Delgado, AnnaAbós, AlexandraCompta, YaroslauMartí Domènech, Ma. JosepValldeoriola Serra, FrancescBargalló Alabart, NúriaJunqué i Plaja, Carme, 1955-Malaltia de ParkinsonEnvellimentNeurologiaParkinson's diseaseAgingNeurologyHippocampal subfields have different vulnerability to the degenerative processes related to aging, amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the temporal evolution in Parkinson's disease (PD) is unknown. The purposes of the current work are to describe regional hippocampal changes over time in a sample of PD patients classified according to their baseline cognitive status and to relate these changes to verbal memory loss. T1-weighted images and verbal memory assessment were obtained at two separate time points (3.8 ± 0.4 years apart) from 28 PD with normal cognition (PD-NC), 16 PD with MCI (PD-MCI) and 21 healthy controls (HCs). FreeSurfer 6.0 automated pipeline was used to segment the hippocampus into 12 bilateral subregions. Memory functions were measured with Rey's Auditory Verbal learning test (RAVLT). We found significant reductions in cornu ammonis 1 (CA1) over time in controls as well as in PD subgroups. Right whole-hippocampal volumes showed time effects in both PD groups but not in controls. PD-NC patients also displayed time effects in the left hippocampal tail and right parasubiculum. Regression analyses showed that specific hippocampal subfield volumes at time 1 predicted almost 60% of the variability in RAVLT delayed-recall score decline. Changes in several hippocampal subregions also showed predictive value for memory loss. In conclusion, CA1 changes in PD were similar to those that occur in normal aging, but PD patients also had more decline in both anterior and posterior hippocampal segments with a more pronounced atrophy of the right hemisphere. Hippocampal segments are better predictors of changes in memory performance than whole-hippocampal volumes.Frontiers Media2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/140428Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fnagi.2018.00325Frontiers in Aging Neuroscience, 2018, vol. 10, p. 325https://doi.org/10.3389/fnagi.2018.00325cc-by (c) Uribe Codesal, Ma. Del Carmen et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1404282026-05-29T05:05:01Z
dc.title.none.fl_str_mv Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
spellingShingle Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
Uribe, Carme
Malaltia de Parkinson
Envelliment
Neurologia
Parkinson's disease
Aging
Neurology
title_short Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title_full Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title_fullStr Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title_full_unstemmed Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title_sort Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
dc.creator.none.fl_str_mv Uribe, Carme
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Campabadal Delgado, Anna
Abós, Alexandra
Compta, Yaroslau
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author Uribe, Carme
author_facet Uribe, Carme
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Campabadal Delgado, Anna
Abós, Alexandra
Compta, Yaroslau
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author_role author
author2 Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Campabadal Delgado, Anna
Abós, Alexandra
Compta, Yaroslau
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Parkinson
Envelliment
Neurologia
Parkinson's disease
Aging
Neurology
topic Malaltia de Parkinson
Envelliment
Neurologia
Parkinson's disease
Aging
Neurology
description Hippocampal subfields have different vulnerability to the degenerative processes related to aging, amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the temporal evolution in Parkinson's disease (PD) is unknown. The purposes of the current work are to describe regional hippocampal changes over time in a sample of PD patients classified according to their baseline cognitive status and to relate these changes to verbal memory loss. T1-weighted images and verbal memory assessment were obtained at two separate time points (3.8 ± 0.4 years apart) from 28 PD with normal cognition (PD-NC), 16 PD with MCI (PD-MCI) and 21 healthy controls (HCs). FreeSurfer 6.0 automated pipeline was used to segment the hippocampus into 12 bilateral subregions. Memory functions were measured with Rey's Auditory Verbal learning test (RAVLT). We found significant reductions in cornu ammonis 1 (CA1) over time in controls as well as in PD subgroups. Right whole-hippocampal volumes showed time effects in both PD groups but not in controls. PD-NC patients also displayed time effects in the left hippocampal tail and right parasubiculum. Regression analyses showed that specific hippocampal subfield volumes at time 1 predicted almost 60% of the variability in RAVLT delayed-recall score decline. Changes in several hippocampal subregions also showed predictive value for memory loss. In conclusion, CA1 changes in PD were similar to those that occur in normal aging, but PD patients also had more decline in both anterior and posterior hippocampal segments with a more pronounced atrophy of the right hemisphere. Hippocampal segments are better predictors of changes in memory performance than whole-hippocampal volumes.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/140428
url https://hdl.handle.net/2445/140428
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2018.00325
Frontiers in Aging Neuroscience, 2018, vol. 10, p. 325
https://doi.org/10.3389/fnagi.2018.00325
dc.rights.none.fl_str_mv cc-by (c) Uribe Codesal, Ma. Del Carmen et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Uribe Codesal, Ma. Del Carmen et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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