Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.

Endometrial cancer, the most prevalent gynecological malignancy in developed countries, is experiencing a sustained rise in both its incidence and mortality rates, primarily attributed to extended life expectancy and lifestyle factors. Currently, the absence of precise diagnostic tools hampers the e...

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Authors: Albertí Valls, Manel, Megino-Luque, Cristina, Macià Armengol, Anna, Gatius Calderó, Sònia, Matias-Guiu, Xavier, Eritja Sánchez, Núria
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/465813
Online Access:https://doi.org/10.3390/cancers16010185
https://hdl.handle.net/10459.1/465813
Access Level:Open access
Keyword:Biomarker discovery
Endometrial cancer
Metabolic profile
Metabolomics
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spelling Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.Albertí Valls, ManelMegino-Luque, CristinaMacià Armengol, AnnaGatius Calderó, SòniaMatias-Guiu, XavierEritja Sánchez, NúriaBiomarker discoveryEndometrial cancerMetabolic profileMetabolomicsEndometrial cancer, the most prevalent gynecological malignancy in developed countries, is experiencing a sustained rise in both its incidence and mortality rates, primarily attributed to extended life expectancy and lifestyle factors. Currently, the absence of precise diagnostic tools hampers the effective management of the expanding population of women at risk of developing this disease. Furthermore, patients diagnosed with endometrial cancer require precise risk stratification to align with optimal treatment planning. Metabolomics technology offers a unique insight into the molecular landscape of endometrial cancer, providing a promising approach to address these unmet needs. This comprehensive literature review initiates with an overview of metabolomic technologies and their intrinsic workflow components, aiming to establish a fundamental understanding for the readers. Subsequently, a detailed exploration of the existing body of research is undertaken with the objective of identifying metabolite biomarkers capable of enhancing current strategies for endometrial cancer diagnosis, prognosis, and recurrence monitoring. Metabolomics holds vast potential to revolutionize the management of endometrial cancer by providing accuracy and valuable insights into crucial aspects.This study has been funded by Instituto de Salud Carlos III through the projects “PI20/00502” and “CB16/12/00231” (Co-funded by European Regional Development Fund/European Social Fund “A way to make Europe”/“Investing in your future”). We also thank the Generalitat of Catalonia, Agency for Management of University and Research Grants (2021SGR00093). M.A-V. holds a predoctoral fellowship from the Universitat de Lleida. C.M.-L. received support from the Ramon Areces Foundation.MDPI2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/cancers16010185https://hdl.handle.net/10459.1/465813reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.3390/cancers16010185Cancers, 2024, vol. 16, núm. 1, art. núm. 185cc-by (c) Albertí Valls et al., 2024Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/4658132026-05-29T05:05:01Z
dc.title.none.fl_str_mv Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.
title Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.
spellingShingle Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.
Albertí Valls, Manel
Biomarker discovery
Endometrial cancer
Metabolic profile
Metabolomics
title_short Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.
title_full Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.
title_fullStr Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.
title_full_unstemmed Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.
title_sort Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review.
dc.creator.none.fl_str_mv Albertí Valls, Manel
Megino-Luque, Cristina
Macià Armengol, Anna
Gatius Calderó, Sònia
Matias-Guiu, Xavier
Eritja Sánchez, Núria
author Albertí Valls, Manel
author_facet Albertí Valls, Manel
Megino-Luque, Cristina
Macià Armengol, Anna
Gatius Calderó, Sònia
Matias-Guiu, Xavier
Eritja Sánchez, Núria
author_role author
author2 Megino-Luque, Cristina
Macià Armengol, Anna
Gatius Calderó, Sònia
Matias-Guiu, Xavier
Eritja Sánchez, Núria
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Biomarker discovery
Endometrial cancer
Metabolic profile
Metabolomics
topic Biomarker discovery
Endometrial cancer
Metabolic profile
Metabolomics
description Endometrial cancer, the most prevalent gynecological malignancy in developed countries, is experiencing a sustained rise in both its incidence and mortality rates, primarily attributed to extended life expectancy and lifestyle factors. Currently, the absence of precise diagnostic tools hampers the effective management of the expanding population of women at risk of developing this disease. Furthermore, patients diagnosed with endometrial cancer require precise risk stratification to align with optimal treatment planning. Metabolomics technology offers a unique insight into the molecular landscape of endometrial cancer, providing a promising approach to address these unmet needs. This comprehensive literature review initiates with an overview of metabolomic technologies and their intrinsic workflow components, aiming to establish a fundamental understanding for the readers. Subsequently, a detailed exploration of the existing body of research is undertaken with the objective of identifying metabolite biomarkers capable of enhancing current strategies for endometrial cancer diagnosis, prognosis, and recurrence monitoring. Metabolomics holds vast potential to revolutionize the management of endometrial cancer by providing accuracy and valuable insights into crucial aspects.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/cancers16010185
https://hdl.handle.net/10459.1/465813
url https://doi.org/10.3390/cancers16010185
https://hdl.handle.net/10459.1/465813
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/cancers16010185
Cancers, 2024, vol. 16, núm. 1, art. núm. 185
dc.rights.none.fl_str_mv cc-by (c) Albertí Valls et al., 2024
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Albertí Valls et al., 2024
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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