Biological variability of human intraepithelial lymphocytes throughout the human gastrointestinal tract in health and coeliac disease

[Background]: Intraepithelial lymphocytes are the first line of defence of the human intestinal immune system. Besides, their composition is altered on patients with coeliac disease (CD), so they are considered as biomarkers with utility on their diagnose and/or monitoring. Our aim is to address the...

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Detalhes bibliográficos
Autores: Fiz-López, Aida, Prado-Santos, Ángel de, Arribas, Elisa, García-Alonso, Francisco Javier, Izquierdo, Sandra, Martín-Muñoz, Álvaro, Garrote, José Antonio, Arranz, Eduardo, Barrio, Jesús, Fernández-Salazar, Luis, Bernardo, David
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/384607
Acesso em linha:http://hdl.handle.net/10261/384607
Access Level:acceso abierto
Palavra-chave:Coeliac disease
IL-15Rα
Intraepithelial lymphocytes
Descrição
Resumo:[Background]: Intraepithelial lymphocytes are the first line of defence of the human intestinal immune system. Besides, their composition is altered on patients with coeliac disease (CD), so they are considered as biomarkers with utility on their diagnose and/or monitoring. Our aim is to address their variability through the human gastrointestinal tract in health and characterized them in further depth in the coeliac duodenum.