Oxysterols: A world to explore
Oxysterols (oxidized derivatives of cholesterol and phytosterols) can be generated in the human organism through different oxidation processes, some requiring enzymes. Furthermore, oxysterols are also present in food due to lipid oxidation reactions caused by heating treatments, contact with oxygen,...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/22994 |
| Acceso en línea: | https://hdl.handle.net/10171/22994 |
| Access Level: | acceso abierto |
| Palabra clave: | COPs POPs Oxidation Cholesterol Phytosterols Oxysterols |
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Oxysterols: A world to exploreOtaegui-Arrazola, A. (Ana)|||/items/1f06f3b7-1650-4c2c-b8b6-a554389db225Menendez-Carreño, M. (María)|||/items/3cc43ac0-63f9-4e93-8647-26c827458a6bAnsorena-Artieda, D. (Diana)|||/items/3ac83dfe-b2e3-4a2d-a7e4-2813388afc29Astiasarán, I. (Iciar)|||/items/34b867c2-957e-4a1f-8a1d-c0a6a8e6b70bCOPsPOPsOxidationCholesterolPhytosterolsOxysterolsOxysterols (oxidized derivatives of cholesterol and phytosterols) can be generated in the human organism through different oxidation processes, some requiring enzymes. Furthermore, oxysterols are also present in food due to lipid oxidation reactions caused by heating treatments, contact with oxygen, exposure to sunlight, etc., and they could be absorbed from the diet, at different rates depending on their side chain length. In the organism, oxysterols can follow different routes: secreted into the intestinal lumen, esterified and distributed by lipoproteins to different tissues or degraded, mainly in the liver. Cholesterol oxidation products (COPs) have shown cytotoxicity, apoptotic and pro-inflammatory effects and they have also been linked with chronic diseases including atherosclerotic and neurodegenerative processess. In the case of phytosterol oxidation products (POPs), more research is needed on toxic effects. Nevertheless, current knowledge suggests they may also cause cytotoxic and pro-apoptotic effects, although at higher concentrations than COPs. Recently, new beneficial biological activities of oxysterols are being investigated. Whereas COPs are associated with cholesterol homeostasis mediated by different mechanisms, the implication of POPs is not clear yet. Available literature on sources of oxysterols in the organism, metabolism, toxicity and potential beneficial effects of these compounds are reviewed in this paper.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20122012-08-0520102010-01-0120102010-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/22994reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/229942026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Oxysterols: A world to explore |
| title |
Oxysterols: A world to explore |
| spellingShingle |
Oxysterols: A world to explore Otaegui-Arrazola, A. (Ana)|||/items/1f06f3b7-1650-4c2c-b8b6-a554389db225 COPs POPs Oxidation Cholesterol Phytosterols Oxysterols |
| title_short |
Oxysterols: A world to explore |
| title_full |
Oxysterols: A world to explore |
| title_fullStr |
Oxysterols: A world to explore |
| title_full_unstemmed |
Oxysterols: A world to explore |
| title_sort |
Oxysterols: A world to explore |
| dc.creator.none.fl_str_mv |
Otaegui-Arrazola, A. (Ana)|||/items/1f06f3b7-1650-4c2c-b8b6-a554389db225 Menendez-Carreño, M. (María)|||/items/3cc43ac0-63f9-4e93-8647-26c827458a6b Ansorena-Artieda, D. (Diana)|||/items/3ac83dfe-b2e3-4a2d-a7e4-2813388afc29 Astiasarán, I. (Iciar)|||/items/34b867c2-957e-4a1f-8a1d-c0a6a8e6b70b |
| author |
Otaegui-Arrazola, A. (Ana)|||/items/1f06f3b7-1650-4c2c-b8b6-a554389db225 |
| author_facet |
Otaegui-Arrazola, A. (Ana)|||/items/1f06f3b7-1650-4c2c-b8b6-a554389db225 Menendez-Carreño, M. (María)|||/items/3cc43ac0-63f9-4e93-8647-26c827458a6b Ansorena-Artieda, D. (Diana)|||/items/3ac83dfe-b2e3-4a2d-a7e4-2813388afc29 Astiasarán, I. (Iciar)|||/items/34b867c2-957e-4a1f-8a1d-c0a6a8e6b70b |
| author_role |
author |
| author2 |
Menendez-Carreño, M. (María)|||/items/3cc43ac0-63f9-4e93-8647-26c827458a6b Ansorena-Artieda, D. (Diana)|||/items/3ac83dfe-b2e3-4a2d-a7e4-2813388afc29 Astiasarán, I. (Iciar)|||/items/34b867c2-957e-4a1f-8a1d-c0a6a8e6b70b |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
COPs POPs Oxidation Cholesterol Phytosterols Oxysterols |
| topic |
COPs POPs Oxidation Cholesterol Phytosterols Oxysterols |
| description |
Oxysterols (oxidized derivatives of cholesterol and phytosterols) can be generated in the human organism through different oxidation processes, some requiring enzymes. Furthermore, oxysterols are also present in food due to lipid oxidation reactions caused by heating treatments, contact with oxygen, exposure to sunlight, etc., and they could be absorbed from the diet, at different rates depending on their side chain length. In the organism, oxysterols can follow different routes: secreted into the intestinal lumen, esterified and distributed by lipoproteins to different tissues or degraded, mainly in the liver. Cholesterol oxidation products (COPs) have shown cytotoxicity, apoptotic and pro-inflammatory effects and they have also been linked with chronic diseases including atherosclerotic and neurodegenerative processess. In the case of phytosterol oxidation products (POPs), more research is needed on toxic effects. Nevertheless, current knowledge suggests they may also cause cytotoxic and pro-apoptotic effects, although at higher concentrations than COPs. Recently, new beneficial biological activities of oxysterols are being investigated. Whereas COPs are associated with cholesterol homeostasis mediated by different mechanisms, the implication of POPs is not clear yet. Available literature on sources of oxysterols in the organism, metabolism, toxicity and potential beneficial effects of these compounds are reviewed in this paper. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010 2010-01-01 2010 2010-01-01 2012 2012-08-05 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/22994 |
| url |
https://hdl.handle.net/10171/22994 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869412432222355456 |
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15,300719 |