Mitochondrial fatty acid oxidation in obesity

Significance: Current lifestyles with high-energy diets and little exercise are triggering an alarming growth in obesity. Excess of adiposity is leading to severe increases in associated pathologies, such as insulin resistance, type 2 diabetes, atherosclerosis, cancer, arthritis, asthma, and hyperte...

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Autores: Serra i Cucurull, Dolors, Mera Nanín, Paula, Malandrino, Maria Ida, Mir Bonnín, Joan Francesc, Herrero Rodríguez, Laura
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/50573
Acceso en línea:https://hdl.handle.net/2445/50573
Access Level:acceso abierto
Palabra clave:Àcids grassos
Terapèutica
Teixit adipós
Quimioteràpia
Reacció d'oxidació-reducció
Metabolisme dels lípids
Obesitat
Mitocondris
Fatty acids
Therapeutics
Adipose tissues
Chemotherapy
Oxidation-reduction reaction
Lipid metabolism
Obesity
Mitochondria
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spelling Mitochondrial fatty acid oxidation in obesitySerra i Cucurull, DolorsMera Nanín, PaulaMalandrino, Maria IdaMir Bonnín, Joan FrancescHerrero Rodríguez, LauraÀcids grassosTerapèuticaTeixit adipósQuimioteràpiaReacció d'oxidació-reduccióMetabolisme dels lípidsObesitatMitocondrisFatty acidsTherapeuticsAdipose tissuesChemotherapyOxidation-reduction reactionLipid metabolismObesityMitochondriaSignificance: Current lifestyles with high-energy diets and little exercise are triggering an alarming growth in obesity. Excess of adiposity is leading to severe increases in associated pathologies, such as insulin resistance, type 2 diabetes, atherosclerosis, cancer, arthritis, asthma, and hypertension. This, together with the lack of efficient obesity drugs, is the driving force behind much research. Recent Advances: Traditional anti-obesity strategies focused on reducing food intake and increasing physical activity. However, recent results suggest that enhancing cellular energy expenditure may be an attractive alternative therapy. Critical Issues: This review evaluates recent discoveries regarding mitochondrial fatty acid oxidation (FAO) and its potential as a therapy for obesity. We focus on the still controversial beneficial effects of increased FAO in liver and muscle, recent studies on how to potentiate adipose tissue energy expenditure, and the different hypotheses involving FAO and the reactive oxygen species production in the hypothalamic control of food intake. Future Directions: The present review aims to provide an overview of novel anti-obesity strategies that target mitochondrial FAO and that will definitively be of high interest in the future research to fight against obesity-related disorders.Mary Ann Liebert, Inc.2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/50573Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1089/ars.2012.4875Antioxidants & Redox Signaling, 2013, vol. 19, num. 3, p. 269-284http://dx.doi.org/10.1089/ars.2012.4875(c) Mary Ann Liebert, Inc., 2013info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/505732026-05-27T06:46:51Z
dc.title.none.fl_str_mv Mitochondrial fatty acid oxidation in obesity
title Mitochondrial fatty acid oxidation in obesity
spellingShingle Mitochondrial fatty acid oxidation in obesity
Serra i Cucurull, Dolors
Àcids grassos
Terapèutica
Teixit adipós
Quimioteràpia
Reacció d'oxidació-reducció
Metabolisme dels lípids
Obesitat
Mitocondris
Fatty acids
Therapeutics
Adipose tissues
Chemotherapy
Oxidation-reduction reaction
Lipid metabolism
Obesity
Mitochondria
title_short Mitochondrial fatty acid oxidation in obesity
title_full Mitochondrial fatty acid oxidation in obesity
title_fullStr Mitochondrial fatty acid oxidation in obesity
title_full_unstemmed Mitochondrial fatty acid oxidation in obesity
title_sort Mitochondrial fatty acid oxidation in obesity
dc.creator.none.fl_str_mv Serra i Cucurull, Dolors
Mera Nanín, Paula
Malandrino, Maria Ida
Mir Bonnín, Joan Francesc
Herrero Rodríguez, Laura
author Serra i Cucurull, Dolors
author_facet Serra i Cucurull, Dolors
Mera Nanín, Paula
Malandrino, Maria Ida
Mir Bonnín, Joan Francesc
Herrero Rodríguez, Laura
author_role author
author2 Mera Nanín, Paula
Malandrino, Maria Ida
Mir Bonnín, Joan Francesc
Herrero Rodríguez, Laura
author2_role author
author
author
author
dc.subject.none.fl_str_mv Àcids grassos
Terapèutica
Teixit adipós
Quimioteràpia
Reacció d'oxidació-reducció
Metabolisme dels lípids
Obesitat
Mitocondris
Fatty acids
Therapeutics
Adipose tissues
Chemotherapy
Oxidation-reduction reaction
Lipid metabolism
Obesity
Mitochondria
topic Àcids grassos
Terapèutica
Teixit adipós
Quimioteràpia
Reacció d'oxidació-reducció
Metabolisme dels lípids
Obesitat
Mitocondris
Fatty acids
Therapeutics
Adipose tissues
Chemotherapy
Oxidation-reduction reaction
Lipid metabolism
Obesity
Mitochondria
description Significance: Current lifestyles with high-energy diets and little exercise are triggering an alarming growth in obesity. Excess of adiposity is leading to severe increases in associated pathologies, such as insulin resistance, type 2 diabetes, atherosclerosis, cancer, arthritis, asthma, and hypertension. This, together with the lack of efficient obesity drugs, is the driving force behind much research. Recent Advances: Traditional anti-obesity strategies focused on reducing food intake and increasing physical activity. However, recent results suggest that enhancing cellular energy expenditure may be an attractive alternative therapy. Critical Issues: This review evaluates recent discoveries regarding mitochondrial fatty acid oxidation (FAO) and its potential as a therapy for obesity. We focus on the still controversial beneficial effects of increased FAO in liver and muscle, recent studies on how to potentiate adipose tissue energy expenditure, and the different hypotheses involving FAO and the reactive oxygen species production in the hypothalamic control of food intake. Future Directions: The present review aims to provide an overview of novel anti-obesity strategies that target mitochondrial FAO and that will definitively be of high interest in the future research to fight against obesity-related disorders.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/50573
url https://hdl.handle.net/2445/50573
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1089/ars.2012.4875
Antioxidants & Redox Signaling, 2013, vol. 19, num. 3, p. 269-284
http://dx.doi.org/10.1089/ars.2012.4875
dc.rights.none.fl_str_mv (c) Mary Ann Liebert, Inc., 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Mary Ann Liebert, Inc., 2013
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert, Inc.
publisher.none.fl_str_mv Mary Ann Liebert, Inc.
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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