Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis

Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary...

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Autores: López Mejías, Raquel, Genre, Fernanda, García Bermúdez, Mercedes, Ubilla García, Begoña, Castañeda Sanz, Santos, Llorca Díaz, Francisco Javier|||0000-0001-8569-861X, González Juanatey, Carlos, Corrales Martínez, Alfonso, Miranda Filloy, José Alberto, Pina Murcia, Trinitario, Gómez Vaquero, Carmen, Rodríguez Rodríguez, Luis, Fernández Gutiérrez, Benjamín, Balsa Criado, Alejandro, Pascual Salcedo, Dora, López Longo, Francisco J., Carreira Delgado, Patricia, Blanco Alonso, Ricardo|||0000-0003-2344-2285, Martín Ibáñez, Javier, González-Gay Mantecón, Miguel Ángel
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/4671
Acceso en línea:http://hdl.handle.net/10902/4671
Access Level:acceso abierto
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spelling Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritisLópez Mejías, RaquelGenre, FernandaGarcía Bermúdez, MercedesUbilla García, BegoñaCastañeda Sanz, SantosLlorca Díaz, Francisco Javier|||0000-0001-8569-861XGonzález Juanatey, CarlosCorrales Martínez, AlfonsoMiranda Filloy, José AlbertoPina Murcia, TrinitarioGómez Vaquero, CarmenRodríguez Rodríguez, LuisFernández Gutiérrez, BenjamínBalsa Criado, AlejandroPascual Salcedo, DoraLópez Longo, Francisco J.Carreira Delgado, PatriciaBlanco Alonso, Ricardo|||0000-0003-2344-2285Martín Ibáñez, JavierGonzález-Gay Mantecón, Miguel ÁngelIntroduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT) and presence/absence of carotid plaques) and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.Acknowledgments. The authors wish to thank all the patients with RA that participated to make this study possible. We want to specially thank Rodrigo Ochoa, SofÍa Vargas, M. Luisa López, M. Jesus Ibañez, and Sara Olavarria for their technical assistance. This study was supported by European Union FEDER Funds and “Fondo de Investigación Sanitaria” (Grants PI06/0024, PS09/00748, and PI12/00060) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009/0013 and RD12/0009/0004 (RIER) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain) and in part by grants from the European IMI BTCure Program. Raquel Lopez-Mejías is a recipient of Sara Borrell postdoctoral fellowship from the Instituto Carlos III de Salud at the Spanish Ministry of Health (Spain) (CD12/00425). Fernanda Genre and Begoña Ubilla are supported by Funds from the RETICS Program (RIER) (RD12/0009/0013). Mercedes García-Bermúdez is a beneficiary of a grant from Fundación Española de Reumatología (FER).Hindawi Publishing CorporationUniversidad de Cantabria20142014-03-25journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/4671Mediators of Inflammation. 2014;2014:756279. Epub 2014 Mar 25reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/46712026-06-02T12:39:31Z
dc.title.none.fl_str_mv Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis
title Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis
spellingShingle Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis
López Mejías, Raquel
title_short Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis
title_full Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis
title_fullStr Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis
title_full_unstemmed Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis
title_sort Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis
dc.creator.none.fl_str_mv López Mejías, Raquel
Genre, Fernanda
García Bermúdez, Mercedes
Ubilla García, Begoña
Castañeda Sanz, Santos
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
González Juanatey, Carlos
Corrales Martínez, Alfonso
Miranda Filloy, José Alberto
Pina Murcia, Trinitario
Gómez Vaquero, Carmen
Rodríguez Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa Criado, Alejandro
Pascual Salcedo, Dora
López Longo, Francisco J.
Carreira Delgado, Patricia
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Martín Ibáñez, Javier
González-Gay Mantecón, Miguel Ángel
author López Mejías, Raquel
author_facet López Mejías, Raquel
Genre, Fernanda
García Bermúdez, Mercedes
Ubilla García, Begoña
Castañeda Sanz, Santos
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
González Juanatey, Carlos
Corrales Martínez, Alfonso
Miranda Filloy, José Alberto
Pina Murcia, Trinitario
Gómez Vaquero, Carmen
Rodríguez Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa Criado, Alejandro
Pascual Salcedo, Dora
López Longo, Francisco J.
Carreira Delgado, Patricia
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Martín Ibáñez, Javier
González-Gay Mantecón, Miguel Ángel
author_role author
author2 Genre, Fernanda
García Bermúdez, Mercedes
Ubilla García, Begoña
Castañeda Sanz, Santos
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
González Juanatey, Carlos
Corrales Martínez, Alfonso
Miranda Filloy, José Alberto
Pina Murcia, Trinitario
Gómez Vaquero, Carmen
Rodríguez Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa Criado, Alejandro
Pascual Salcedo, Dora
López Longo, Francisco J.
Carreira Delgado, Patricia
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Martín Ibáñez, Javier
González-Gay Mantecón, Miguel Ángel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
description Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT) and presence/absence of carotid plaques) and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-03-25
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/4671
url http://hdl.handle.net/10902/4671
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Mediators of Inflammation. 2014;2014:756279. Epub 2014 Mar 25
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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