The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume

Purpose: To relate the prostate volume category (PVC) assessed with digital rectal examination (DRE)-small, median, and large-and the prostate volumes (PVs) assessed with magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS). To compare the clinically significant prostate cancer (csPCa)...

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Autores: Morote, Juan, Picola, Natàlia, Muñoz-Rodríguez, Jesús, Paesano, Nahuel, Ruiz Plazas, Xavier, Muñoz-Rivero, Marta V., Celma, Anna, García de Manuel, Gemma, Miró, Berta, Abascal-Junquera, José María, Servian, Pol
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/68470
Acceso en línea:http://hdl.handle.net/10230/68470
http://dx.doi.org/10.5534/wjmh.230028
Access Level:acceso abierto
Palabra clave:Digital rectal examination
Magnetic resonance imaging
Predictive model
Prostate volume
Prostate volume category
Transrectal ultrasound
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spelling The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volumeMorote, JuanPicola, NatàliaMuñoz-Rodríguez, JesúsPaesano, NahuelRuiz Plazas, XavierMuñoz-Rivero, Marta V.Celma, AnnaGarcía de Manuel, GemmaMiró, BertaAbascal-Junquera, José MaríaServian, PolDigital rectal examinationMagnetic resonance imagingPredictive modelProstate volumeProstate volume categoryTransrectal ultrasoundPurpose: To relate the prostate volume category (PVC) assessed with digital rectal examination (DRE)-small, median, and large-and the prostate volumes (PVs) assessed with magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS). To compare the clinically significant prostate cancer (csPCa) discrimination ability of two predictive models based on DRE-PVC and MRI-PV. Materials and methods: A prospective trial of 2,090 men with prostate-specific antigen >3 ng/mL and/or PCa suspicious DRE were prospectively recruited in 10 centers from Catalonia (Spain), between 2021 and 2022, in whom DRE-PVC was assessed. Pre-biopsy MRI, and 12-core TRUS-random biopsy was always performed after 2- to 6-core TRUS-fusion targeted biopsy of prostate imaging-report and data system >3 lesions. In 370 men (17.7%) the DRE-PVC was unconclusive. Among the 1,720 men finally analyzed the csPCa (grade group >2) detection was 42.4%. Results: The median (interquartile range) of TRUS and MRI-PVs of small prostates were 33 mL (19-37 mL) and 35 mL (23-30 mL), p=0.410; in median prostates they were 51 mL (38-58 mL) and 55 mL (48-63 mL) respectively, p<0.001; in large prostates 80 mL (60-100 mL) and 95 mL (75-118 mL) respectively, p<0.001. The predictive models sharing the MRI-PV and DRE-PVC showed areas under the curves of 0.832 (95% confidence interval [CI], 0.813-0.851) and 0.828 (95% CI, 0.809-0.848) respectively, p=0.632, as well as similar net benefit and clinical utility. Conclusions: PVC was unconclusive in 17% of DREs. MRI-PV overestimated the TRUS-PV in median and large prostates. The predictive models based on MRI-PV and DRE-PVC showed similar efficacy to predict csPCa. PVC assessed with DRE is helpful to predict the csPCa risk before MRI.Korean Society for Sexual Medicine and Andrology202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/68470http://dx.doi.org/10.5534/wjmh.230028reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésWorld J Mens Health. 2024 Apr;42(2):441-8This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10230/684702026-05-29T05:05:01Z
dc.title.none.fl_str_mv The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume
title The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume
spellingShingle The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume
Morote, Juan
Digital rectal examination
Magnetic resonance imaging
Predictive model
Prostate volume
Prostate volume category
Transrectal ultrasound
title_short The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume
title_full The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume
title_fullStr The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume
title_full_unstemmed The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume
title_sort The role of digital rectal examination prostate volume category in the early detection of prostate cancer: Its correlation with the magnetic resonance imaging prostate volume
dc.creator.none.fl_str_mv Morote, Juan
Picola, Natàlia
Muñoz-Rodríguez, Jesús
Paesano, Nahuel
Ruiz Plazas, Xavier
Muñoz-Rivero, Marta V.
Celma, Anna
García de Manuel, Gemma
Miró, Berta
Abascal-Junquera, José María
Servian, Pol
author Morote, Juan
author_facet Morote, Juan
Picola, Natàlia
Muñoz-Rodríguez, Jesús
Paesano, Nahuel
Ruiz Plazas, Xavier
Muñoz-Rivero, Marta V.
Celma, Anna
García de Manuel, Gemma
Miró, Berta
Abascal-Junquera, José María
Servian, Pol
author_role author
author2 Picola, Natàlia
Muñoz-Rodríguez, Jesús
Paesano, Nahuel
Ruiz Plazas, Xavier
Muñoz-Rivero, Marta V.
Celma, Anna
García de Manuel, Gemma
Miró, Berta
Abascal-Junquera, José María
Servian, Pol
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Digital rectal examination
Magnetic resonance imaging
Predictive model
Prostate volume
Prostate volume category
Transrectal ultrasound
topic Digital rectal examination
Magnetic resonance imaging
Predictive model
Prostate volume
Prostate volume category
Transrectal ultrasound
description Purpose: To relate the prostate volume category (PVC) assessed with digital rectal examination (DRE)-small, median, and large-and the prostate volumes (PVs) assessed with magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS). To compare the clinically significant prostate cancer (csPCa) discrimination ability of two predictive models based on DRE-PVC and MRI-PV. Materials and methods: A prospective trial of 2,090 men with prostate-specific antigen >3 ng/mL and/or PCa suspicious DRE were prospectively recruited in 10 centers from Catalonia (Spain), between 2021 and 2022, in whom DRE-PVC was assessed. Pre-biopsy MRI, and 12-core TRUS-random biopsy was always performed after 2- to 6-core TRUS-fusion targeted biopsy of prostate imaging-report and data system >3 lesions. In 370 men (17.7%) the DRE-PVC was unconclusive. Among the 1,720 men finally analyzed the csPCa (grade group >2) detection was 42.4%. Results: The median (interquartile range) of TRUS and MRI-PVs of small prostates were 33 mL (19-37 mL) and 35 mL (23-30 mL), p=0.410; in median prostates they were 51 mL (38-58 mL) and 55 mL (48-63 mL) respectively, p<0.001; in large prostates 80 mL (60-100 mL) and 95 mL (75-118 mL) respectively, p<0.001. The predictive models sharing the MRI-PV and DRE-PVC showed areas under the curves of 0.832 (95% confidence interval [CI], 0.813-0.851) and 0.828 (95% CI, 0.809-0.848) respectively, p=0.632, as well as similar net benefit and clinical utility. Conclusions: PVC was unconclusive in 17% of DREs. MRI-PV overestimated the TRUS-PV in median and large prostates. The predictive models based on MRI-PV and DRE-PVC showed similar efficacy to predict csPCa. PVC assessed with DRE is helpful to predict the csPCa risk before MRI.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/68470
http://dx.doi.org/10.5534/wjmh.230028
url http://hdl.handle.net/10230/68470
http://dx.doi.org/10.5534/wjmh.230028
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv World J Mens Health. 2024 Apr;42(2):441-8
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Korean Society for Sexual Medicine and Andrology
publisher.none.fl_str_mv Korean Society for Sexual Medicine and Andrology
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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