SUMOylation in the control of cholesterol homeostasis

SUMOylation-protein modification by the small ubiquitin-related modifier (SUMO)-affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for the mai...

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Autores: Talamillo, Ana, Ajuria, Leiore, Grillo, Marco, Barroso Gomila, Orhi, Mayor Martínez, Ugo, Barrio Olano, María Rosa
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/43175
Acceso en línea:http://hdl.handle.net/10810/43175
Access Level:acceso abierto
Palabra clave:SUMOylation
cholesterol homeostasis
ubiquitin-like
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spelling SUMOylation in the control of cholesterol homeostasisTalamillo, AnaAjuria, LeioreGrillo, MarcoBarroso Gomila, OrhiMayor Martínez, UgoBarrio Olano, María RosaSUMOylationcholesterol homeostasisubiquitin-likeSUMOylation-protein modification by the small ubiquitin-related modifier (SUMO)-affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for the maintenance of metabolic homeostasis. Cholesterol is one of the main lipids required to preserve the correct cellular function, contributing to the composition of the plasma membrane and participating in transmembrane receptor signalling. Besides these functions, cholesterol is required for the synthesis of steroid hormones, bile acids, oxysterols and vitamin D. Cholesterol levels need to be tightly regulated: in excess, it is toxic to the cell, and the disruption of its homeostasis is associated with various disorders like atherosclerosis and cardiovascular diseases. This review focuses on the role of SUMO in the regulation of proteins involved in the metabolism of cholesterol.We apologize to those whose related publications could not be cited due to space limitations. We are grateful to all members of Barrio's Lab for comments and suggestions. R.B. acknowledges grant nos. BFU2017-84653-P (MINECO/AEI/FEDER/EU), SEV-2016-0644 (Severo Ochoa Excellence Program, MINECO/AEI), 765445-EU (UbiCODE Program, EU) and SAF2017-90900-REDT (UBIRed Program, MINECO/AEI).The Royal SocietyEuropean Commission202020202020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/43175reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/BFU2017-84653-P/info:eu-repo/grantAgreement/MINECO/SEV-2016-0644/info:eu-repo/grantAgreement/MINECO/SAF2017-90900-REDT/info:eu-repo/grantAgreement/EC/H2020/765445https://royalsocietypublishing.org/doi/full/10.1098/rsob.200054?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmedinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.Atribución 3.0 Españaoai:addi.ehu.eus:10810/431752026-06-18T09:23:17Z
dc.title.none.fl_str_mv SUMOylation in the control of cholesterol homeostasis
title SUMOylation in the control of cholesterol homeostasis
spellingShingle SUMOylation in the control of cholesterol homeostasis
Talamillo, Ana
SUMOylation
cholesterol homeostasis
ubiquitin-like
title_short SUMOylation in the control of cholesterol homeostasis
title_full SUMOylation in the control of cholesterol homeostasis
title_fullStr SUMOylation in the control of cholesterol homeostasis
title_full_unstemmed SUMOylation in the control of cholesterol homeostasis
title_sort SUMOylation in the control of cholesterol homeostasis
dc.creator.none.fl_str_mv Talamillo, Ana
Ajuria, Leiore
Grillo, Marco
Barroso Gomila, Orhi
Mayor Martínez, Ugo
Barrio Olano, María Rosa
author Talamillo, Ana
author_facet Talamillo, Ana
Ajuria, Leiore
Grillo, Marco
Barroso Gomila, Orhi
Mayor Martínez, Ugo
Barrio Olano, María Rosa
author_role author
author2 Ajuria, Leiore
Grillo, Marco
Barroso Gomila, Orhi
Mayor Martínez, Ugo
Barrio Olano, María Rosa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
dc.subject.none.fl_str_mv SUMOylation
cholesterol homeostasis
ubiquitin-like
topic SUMOylation
cholesterol homeostasis
ubiquitin-like
description SUMOylation-protein modification by the small ubiquitin-related modifier (SUMO)-affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for the maintenance of metabolic homeostasis. Cholesterol is one of the main lipids required to preserve the correct cellular function, contributing to the composition of the plasma membrane and participating in transmembrane receptor signalling. Besides these functions, cholesterol is required for the synthesis of steroid hormones, bile acids, oxysterols and vitamin D. Cholesterol levels need to be tightly regulated: in excess, it is toxic to the cell, and the disruption of its homeostasis is associated with various disorders like atherosclerosis and cardiovascular diseases. This review focuses on the role of SUMO in the regulation of proteins involved in the metabolism of cholesterol.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/43175
url http://hdl.handle.net/10810/43175
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/BFU2017-84653-P/
info:eu-repo/grantAgreement/MINECO/SEV-2016-0644/
info:eu-repo/grantAgreement/MINECO/SAF2017-90900-REDT/
info:eu-repo/grantAgreement/EC/H2020/765445
https://royalsocietypublishing.org/doi/full/10.1098/rsob.200054?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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